Striatal Dopamine Transporter Availability is Associated with Sleep Disturbance among Patients with Bipolar I Disorder: A Single-photon Emission Computed Tomography Study Using [(99m)Tc] TRODAT-1

OBJECTIVE: Bipolar disorder (BD) is characterized by the poor sleep quality. Whether the striatal dopamine transporter (DAT) availability is related to sleep quality among patients with BD is unclear. METHODS: Fifty-three euthymic patients with BD (24 BD-I and 29 BD-II) and sixty-eight healthy contr...

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Autores principales: Lu, Tsung-Hua, Lin, Shih-Hsien, Tseng, Huai-Hsuan, Yang, Yen Kuang, Chiu, Nan Tsing, Chen, Po See
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean College of Neuropsychopharmacology 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606428/
https://www.ncbi.nlm.nih.gov/pubmed/36263651
http://dx.doi.org/10.9758/cpn.2022.20.4.768
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author Lu, Tsung-Hua
Lin, Shih-Hsien
Tseng, Huai-Hsuan
Yang, Yen Kuang
Chiu, Nan Tsing
Chen, Po See
author_facet Lu, Tsung-Hua
Lin, Shih-Hsien
Tseng, Huai-Hsuan
Yang, Yen Kuang
Chiu, Nan Tsing
Chen, Po See
author_sort Lu, Tsung-Hua
collection PubMed
description OBJECTIVE: Bipolar disorder (BD) is characterized by the poor sleep quality. Whether the striatal dopamine transporter (DAT) availability is related to sleep quality among patients with BD is unclear. METHODS: Fifty-three euthymic patients with BD (24 BD-I and 29 BD-II) and sixty-eight healthy controls were enrolled. The Chinese Version of the Pittsburgh Sleep Quality Index (PSQI) was used, and the availability of DAT was assessed by single-photon emission computed tomography (SPECT) using [(99m)Tc] TRODAT-1. RESULTS: The sleep disturbance component of the PSQI was significantly associated with the level of DAT availability among patients with BD. CONCLUSION: The striatal dopaminergic activity that contributes to resilience to adversity was associated with sleep pattern among patients with BD.
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spelling pubmed-96064282022-11-30 Striatal Dopamine Transporter Availability is Associated with Sleep Disturbance among Patients with Bipolar I Disorder: A Single-photon Emission Computed Tomography Study Using [(99m)Tc] TRODAT-1 Lu, Tsung-Hua Lin, Shih-Hsien Tseng, Huai-Hsuan Yang, Yen Kuang Chiu, Nan Tsing Chen, Po See Clin Psychopharmacol Neurosci Brief Report OBJECTIVE: Bipolar disorder (BD) is characterized by the poor sleep quality. Whether the striatal dopamine transporter (DAT) availability is related to sleep quality among patients with BD is unclear. METHODS: Fifty-three euthymic patients with BD (24 BD-I and 29 BD-II) and sixty-eight healthy controls were enrolled. The Chinese Version of the Pittsburgh Sleep Quality Index (PSQI) was used, and the availability of DAT was assessed by single-photon emission computed tomography (SPECT) using [(99m)Tc] TRODAT-1. RESULTS: The sleep disturbance component of the PSQI was significantly associated with the level of DAT availability among patients with BD. CONCLUSION: The striatal dopaminergic activity that contributes to resilience to adversity was associated with sleep pattern among patients with BD. Korean College of Neuropsychopharmacology 2022-11-30 2022-11-30 /pmc/articles/PMC9606428/ /pubmed/36263651 http://dx.doi.org/10.9758/cpn.2022.20.4.768 Text en Copyright© 2022, Korean College of Neuropsychopharmacology https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Lu, Tsung-Hua
Lin, Shih-Hsien
Tseng, Huai-Hsuan
Yang, Yen Kuang
Chiu, Nan Tsing
Chen, Po See
Striatal Dopamine Transporter Availability is Associated with Sleep Disturbance among Patients with Bipolar I Disorder: A Single-photon Emission Computed Tomography Study Using [(99m)Tc] TRODAT-1
title Striatal Dopamine Transporter Availability is Associated with Sleep Disturbance among Patients with Bipolar I Disorder: A Single-photon Emission Computed Tomography Study Using [(99m)Tc] TRODAT-1
title_full Striatal Dopamine Transporter Availability is Associated with Sleep Disturbance among Patients with Bipolar I Disorder: A Single-photon Emission Computed Tomography Study Using [(99m)Tc] TRODAT-1
title_fullStr Striatal Dopamine Transporter Availability is Associated with Sleep Disturbance among Patients with Bipolar I Disorder: A Single-photon Emission Computed Tomography Study Using [(99m)Tc] TRODAT-1
title_full_unstemmed Striatal Dopamine Transporter Availability is Associated with Sleep Disturbance among Patients with Bipolar I Disorder: A Single-photon Emission Computed Tomography Study Using [(99m)Tc] TRODAT-1
title_short Striatal Dopamine Transporter Availability is Associated with Sleep Disturbance among Patients with Bipolar I Disorder: A Single-photon Emission Computed Tomography Study Using [(99m)Tc] TRODAT-1
title_sort striatal dopamine transporter availability is associated with sleep disturbance among patients with bipolar i disorder: a single-photon emission computed tomography study using [(99m)tc] trodat-1
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606428/
https://www.ncbi.nlm.nih.gov/pubmed/36263651
http://dx.doi.org/10.9758/cpn.2022.20.4.768
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