Cargando…

Interactive Effects of Serum Leptin Levels and Physical Comorbidity on the Pharmacotherapeutic Response of Depressive Disorders

OBJECTIVE: To investigate individual and interactive associations of baseline serum leptin levels and physical comorbidity with short- and long-term treatment outcomes in outpatients with depressive disorders who received stepwise antidepressant treatment in a naturalistic prospective study design....

Descripción completa

Detalles Bibliográficos
Autores principales: Choi, Wonsuk, Kim, Ju-Wan, Kang, Hee-Ju, Kim, Hee Kyung, Kang, Ho-Cheol, Lee, Ju-Yeon, Kim, Sung-Wan, Stewart, Robert, Kim, Jae-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean College of Neuropsychopharmacology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606432/
https://www.ncbi.nlm.nih.gov/pubmed/36263641
http://dx.doi.org/10.9758/cpn.2022.20.4.662
_version_ 1784818297635602432
author Choi, Wonsuk
Kim, Ju-Wan
Kang, Hee-Ju
Kim, Hee Kyung
Kang, Ho-Cheol
Lee, Ju-Yeon
Kim, Sung-Wan
Stewart, Robert
Kim, Jae-Min
author_facet Choi, Wonsuk
Kim, Ju-Wan
Kang, Hee-Ju
Kim, Hee Kyung
Kang, Ho-Cheol
Lee, Ju-Yeon
Kim, Sung-Wan
Stewart, Robert
Kim, Jae-Min
author_sort Choi, Wonsuk
collection PubMed
description OBJECTIVE: To investigate individual and interactive associations of baseline serum leptin levels and physical comorbidity with short- and long-term treatment outcomes in outpatients with depressive disorders who received stepwise antidepressant treatment in a naturalistic prospective study design. METHODS: Baseline serum leptin levels were measured, and the number of concurrent physical disorders ascertained from 1,094 patients. These patients received initial antidepressant monotherapy; then, for patients with an insufficient response or who experienced uncomfortable side effects, treatment was administered using alternative strategies every 3 weeks in the acute treatment phase (at 3, 6, 9, and 12 weeks) and every 3 months in the continuation treatment phase (at 6, 9, and 12 months). Then, 12-week and 12-month remission, defined as a Hamilton Depression Rating Scale score of ≤7, was estimated. RESULTS: In multivariable logistic regression analyses, individual effects were found only between higher baseline serum leptin levels and 12-week non-remission. Significant interactive effects between higher leptin levels and fewer physical disorders (< 2 physical disorders) on 12-week non-remission were observed. However, neither individual nor interactive effects between leptin levels and physical comorbidity were associated with 12-month remission. CONCLUSION: The combination of serum leptin level and number of physical disorders may be a useful predictor of short-term treatment responses in patients with depressive disorders receiving pharmacotherapy.
format Online
Article
Text
id pubmed-9606432
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Korean College of Neuropsychopharmacology
record_format MEDLINE/PubMed
spelling pubmed-96064322022-11-30 Interactive Effects of Serum Leptin Levels and Physical Comorbidity on the Pharmacotherapeutic Response of Depressive Disorders Choi, Wonsuk Kim, Ju-Wan Kang, Hee-Ju Kim, Hee Kyung Kang, Ho-Cheol Lee, Ju-Yeon Kim, Sung-Wan Stewart, Robert Kim, Jae-Min Clin Psychopharmacol Neurosci Original Article OBJECTIVE: To investigate individual and interactive associations of baseline serum leptin levels and physical comorbidity with short- and long-term treatment outcomes in outpatients with depressive disorders who received stepwise antidepressant treatment in a naturalistic prospective study design. METHODS: Baseline serum leptin levels were measured, and the number of concurrent physical disorders ascertained from 1,094 patients. These patients received initial antidepressant monotherapy; then, for patients with an insufficient response or who experienced uncomfortable side effects, treatment was administered using alternative strategies every 3 weeks in the acute treatment phase (at 3, 6, 9, and 12 weeks) and every 3 months in the continuation treatment phase (at 6, 9, and 12 months). Then, 12-week and 12-month remission, defined as a Hamilton Depression Rating Scale score of ≤7, was estimated. RESULTS: In multivariable logistic regression analyses, individual effects were found only between higher baseline serum leptin levels and 12-week non-remission. Significant interactive effects between higher leptin levels and fewer physical disorders (< 2 physical disorders) on 12-week non-remission were observed. However, neither individual nor interactive effects between leptin levels and physical comorbidity were associated with 12-month remission. CONCLUSION: The combination of serum leptin level and number of physical disorders may be a useful predictor of short-term treatment responses in patients with depressive disorders receiving pharmacotherapy. Korean College of Neuropsychopharmacology 2022-11-30 2022-11-30 /pmc/articles/PMC9606432/ /pubmed/36263641 http://dx.doi.org/10.9758/cpn.2022.20.4.662 Text en Copyright© 2022, Korean College of Neuropsychopharmacology https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Choi, Wonsuk
Kim, Ju-Wan
Kang, Hee-Ju
Kim, Hee Kyung
Kang, Ho-Cheol
Lee, Ju-Yeon
Kim, Sung-Wan
Stewart, Robert
Kim, Jae-Min
Interactive Effects of Serum Leptin Levels and Physical Comorbidity on the Pharmacotherapeutic Response of Depressive Disorders
title Interactive Effects of Serum Leptin Levels and Physical Comorbidity on the Pharmacotherapeutic Response of Depressive Disorders
title_full Interactive Effects of Serum Leptin Levels and Physical Comorbidity on the Pharmacotherapeutic Response of Depressive Disorders
title_fullStr Interactive Effects of Serum Leptin Levels and Physical Comorbidity on the Pharmacotherapeutic Response of Depressive Disorders
title_full_unstemmed Interactive Effects of Serum Leptin Levels and Physical Comorbidity on the Pharmacotherapeutic Response of Depressive Disorders
title_short Interactive Effects of Serum Leptin Levels and Physical Comorbidity on the Pharmacotherapeutic Response of Depressive Disorders
title_sort interactive effects of serum leptin levels and physical comorbidity on the pharmacotherapeutic response of depressive disorders
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606432/
https://www.ncbi.nlm.nih.gov/pubmed/36263641
http://dx.doi.org/10.9758/cpn.2022.20.4.662
work_keys_str_mv AT choiwonsuk interactiveeffectsofserumleptinlevelsandphysicalcomorbidityonthepharmacotherapeuticresponseofdepressivedisorders
AT kimjuwan interactiveeffectsofserumleptinlevelsandphysicalcomorbidityonthepharmacotherapeuticresponseofdepressivedisorders
AT kangheeju interactiveeffectsofserumleptinlevelsandphysicalcomorbidityonthepharmacotherapeuticresponseofdepressivedisorders
AT kimheekyung interactiveeffectsofserumleptinlevelsandphysicalcomorbidityonthepharmacotherapeuticresponseofdepressivedisorders
AT kanghocheol interactiveeffectsofserumleptinlevelsandphysicalcomorbidityonthepharmacotherapeuticresponseofdepressivedisorders
AT leejuyeon interactiveeffectsofserumleptinlevelsandphysicalcomorbidityonthepharmacotherapeuticresponseofdepressivedisorders
AT kimsungwan interactiveeffectsofserumleptinlevelsandphysicalcomorbidityonthepharmacotherapeuticresponseofdepressivedisorders
AT stewartrobert interactiveeffectsofserumleptinlevelsandphysicalcomorbidityonthepharmacotherapeuticresponseofdepressivedisorders
AT kimjaemin interactiveeffectsofserumleptinlevelsandphysicalcomorbidityonthepharmacotherapeuticresponseofdepressivedisorders