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An OX40L mRNA vaccine inhibits the growth of hepatocellular carcinoma

mRNA cancer vaccines show therapeutic potential for malignant tumors, including hepatocellular carcinoma (HCC). We optimized and synthesized stable mRNA encoding costimulator Oxford 40 ligand (OX40L). For systemic delivery, OX40L mRNAs were loaded into lipid nanoparticles (LNPs). The expression and...

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Detalles Bibliográficos
Autores principales:	Deng, Zhuoya, Yang, Hao, Tian, Yuying, Liu, Zherui, Sun, Fang, Yang, Penghui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606466/ https://www.ncbi.nlm.nih.gov/pubmed/36313716 http://dx.doi.org/10.3389/fonc.2022.975408

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