Cargando…

Small-molecule compound SYG-180-2-2 attenuates Staphylococcus aureus virulence by inhibiting hemolysin and staphyloxanthin production

Multi-drug resistant Staphylococcus aureus infection is still a serious threat to global health. Therefore, there is an urgent need to develop new antibacterial agents based on virulence factor therapy to overcome drug resistance. Previously, we synthesized SYG-180-2-2 (C(21)H(16)N(2)OSe), an effect...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rao, Lulin, Xu, Yanlei, Shen, Li, Wang, Xinyi, Zhao, Huilin, Wang, Bingjie, Zhang, Jiao, Xiao, Yanghua, Guo, Yinjuan, Sheng, Yaoguang, Cheng, Lixia, Song, Zengqiang, Yu, Fangyou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606476/ https://www.ncbi.nlm.nih.gov/pubmed/36310881 http://dx.doi.org/10.3389/fcimb.2022.1008289

Ejemplares similares

Small-Molecule Compound SYG-180-2-2 to Effectively Prevent the Biofilm Formation of Methicillin-Resistant Staphylococcus aureus
por: Rao, Lulin, et al.
Publicado: (2022)

Phylogenetic Analysis and Virulence Characteristics of Methicillin-Resistant Staphylococcus aureus ST45 in China: a Hyper-Virulent Clone Associated with Bloodstream Infections
por: Wang, Xinyi, et al.
Publicado: (2023)

The small molecule ZY-214-4 may reduce the virulence of Staphylococcus aureus by inhibiting pigment production
por: Yu, Jingyi, et al.
Publicado: (2021)

Phylogenetic analysis and virulence characteristics of methicillin-resistant Staphylococcus aureus ST764-SCCmec II: an emerging hypervirulent clone ST764-t1084 in China
por: Xiao, Yanghua, et al.
Publicado: (2023)

The Immunoglobulin Superfamily Members syg-2 and syg-1 Regulate Neurite Development in C. elegans
por: Tucker, Dana K., et al.
Publicado: (2022)

Co-Occurrence of Rare ArmA-, RmtB-, and KPC-2–Encoding Multidrug-Resistant Plasmids and Hypervirulence iuc Operon in ST11-KL47 Klebsiella pneumoniae
por: Zhou, Ying, et al.
Publicado: (2022)

Functional Insights of MraZ on the Pathogenicity of Staphylococcus aureus
por: Wang, Bingjie, et al.
Publicado: (2021)

Dissemination of Methicillin-Resistant Staphylococcus aureus Sequence Type 764 Isolates with Mupirocin Resistance in China
por: Guo, Yinjuan, et al.
Publicado: (2023)

Identification of methicillin-resistant Staphylococcus aureus ST8 isolates in China with potential high virulence
por: Wang, Xinyi, et al.
Publicado: (2022)

Small-Molecule Compound CY-158-11 Inhibits Staphylococcus aureus Biofilm Formation
por: Shen, Li, et al.
Publicado: (2023)

Molecular Characteristics of Rifampin-Sensitive and -Resistant Isolates and Characteristics of rpoB Gene Mutations in Methicillin-Resistant Staphylococcus aureus
por: Guo, Yinjuan, et al.
Publicado: (2021)

The Co-occurrence of NDM-5, MCR-1, and FosA3-Encoding Plasmids Contributed to the Generation of Extensively Drug-Resistant Klebsiella pneumoniae
por: Zhou, Ying, et al.
Publicado: (2022)

In Vitro Activity of Vancomycin, Teicoplanin, Linezolid and Daptomycin Against Methicillin-Resistant Staphylococcus aureus Isolates Collected from Chinese Hospitals in 2018–2020
por: Xu, Yanlei, et al.
Publicado: (2021)

Phenotypic and genomic analysis of the hypervirulent ST22 methicillin-resistant Staphylococcus aureus in China
por: Zhao, Huilin, et al.
Publicado: (2023)

Functional and Spatial Analysis of C. elegans SYG-1 and SYG-2, Orthologs of the Neph/Nephrin Cell Adhesion Module Directing Selective Synaptogenesis
por: Wanner, Nicola, et al.
Publicado: (2011)

The Prevalence and Determinants of Fusidic Acid Resistance Among Methicillin-Resistant Staphylococcus aureus Clinical Isolates in China
por: Zhao, Huilin, et al.
Publicado: (2021)

Co-occurrence of OXA-232, RmtF-encoding plasmids, and pLVPK-like virulence plasmid contributed to the generation of ST15-KL112 hypervirulent multidrug-resistant Klebsiella pneumoniae
por: Wu, Chunyang, et al.
Publicado: (2023)

A Natural Dietary Flavone Myricetin as an α-Hemolysin Inhibitor for Controlling Staphylococcus aureus Infection
por: Wang, Tingting, et al.
Publicado: (2020)

Drug Resistance Characteristics of Mycobacterium tuberculosis Isolates From Patients With Tuberculosis to 12 Antituberculous Drugs in China
por: Wu, Xiaocui, et al.
Publicado: (2019)

Staphylococcus aureus β-Hemolysin Up-Regulates the Expression of IFN-γ by Human CD56(bright) NK Cells
por: Guan, Zhangchun, et al.
Publicado: (2021)

Chromone Derivatives CM3a Potently Eradicate Staphylococcus aureus Biofilms by Inhibiting Cell Adherence
por: Zhan, Qing, et al.
Publicado: (2021)

Deletion of SarX Decreases Biofilm Formation of Staphylococcus aureus in a Polysaccharide Intercellular Adhesin (PIA)-Dependent Manner by Downregulating spa
por: Hao, Zhihao, et al.
Publicado: (2021)

Fosfomycin Protects Mice From Staphylococcus aureus Pneumonia Caused by α-Hemolysin in Extracellular Vesicles by Inhibiting MAPK-Regulated NLRP3 Inflammasomes
por: An, Yanan, et al.
Publicado: (2019)

Development of a Molecular Imprinting-Based Surface Plasmon Resonance Biosensor for Rapid and Sensitive Detection of Staphylococcus aureus Alpha Hemolysin From Human Serum
por: Andersson, Tilde, et al.
Publicado: (2020)

Methicillin-resistant Staphylococcus aureus in China: a multicentre longitudinal study and whole-genome sequencing
por: Wang, Bingjie, et al.
Publicado: (2022)

NWMN2330 May Be Associated with the Virulence of Staphylococcus aureus by Increasing the Expression of hla and saeRS
por: Liu, Li, et al.
Publicado: (2022)

Staphyloxanthin: a potential target for antivirulence therapy
por: Xue, Lijun, et al.
Publicado: (2019)

Antibiofilm Activity of Small-Molecule ZY-214-4 Against Staphylococcus aureus
por: Yu, Jingyi, et al.
Publicado: (2021)

An Unusual U2AF2 Inhibits Splicing and Attenuates the Virulence of the Human Protozoan Parasite Entamoeba histolytica
por: González-Blanco, Gretter, et al.
Publicado: (2022)

Robo functions as an attractive cue for glial migration through SYG-1/Neph
por: Qu, Zhongwei, et al.
Publicado: (2020)

Diclofenac and Meloxicam Exhibited Anti-Virulence Activities Targeting Staphyloxanthin Production in Methicillin-Resistant Staphylococcus aureus
por: Elmesseri, Rana A., et al.
Publicado: (2023)

The Msn2 Transcription Factor Regulates Acaricidal Virulence in the Fungal Pathogen Beauveria bassiana
por: Muniz, Elen R., et al.
Publicado: (2021)

RELATION BETWEEN THE VIRULENCE OF STREPTOCOCCI AND HEMOLYSIN
por: Stevens, Franklin A., et al.
Publicado: (1921)

The Redox-Sensing Regulator Rex Contributes to the Virulence and Oxidative Stress Response of Streptococcus suis Serotype 2
por: Zhu, Haodan, et al.
Publicado: (2018)

Effects of di-(2-ethylhexyl) phthalate on growth, metabolism, and virulence of the plant pathogenic bacterium Acidovorax citrulli
por: Kim, Yu-Ri, et al.
Publicado: (2023)

Plasmid-mediated virulence in Chlamydia
por: Turman, Breanna J., et al.
Publicado: (2023)

Subinhibitory concentrations of resveratrol reduce alpha-hemolysin production in Staphylococcus aureus isolates by downregulating saeRS
por: Duan, Jingjing, et al.
Publicado: (2018)

Antimicrobial susceptibility, virulence determinants profiles and molecular characteristics of Staphylococcus epidermidis isolates in Wenzhou, eastern China
por: Guo, Yinjuan, et al.
Publicado: (2019)

Outbreak of IncX8 Plasmid–Mediated KPC-3–Producing Enterobacterales Infection, China
por: Chen, Lan, et al.
Publicado: (2022)

The AI-2/luxS Quorum Sensing System Affects the Growth Characteristics, Biofilm Formation, and Virulence of Haemophilus parasuis
por: Zhang, Bingzhou, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_23fqbd55eam1nedkroarm9nfsd