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Combinational treatments of RNA interference and extracellular vesicles in the spinocerebellar ataxia
Spinocerebellar ataxia (SCA) is an autosomal dominant neurodegenerative disease (ND) with a high mortality rate. Symptomatic treatment is the only clinically adopted treatment. However, it has poor effect and serious complications. Traditional diagnostic methods [such as magnetic resonance imaging (...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606576/ https://www.ncbi.nlm.nih.gov/pubmed/36311034 http://dx.doi.org/10.3389/fnmol.2022.1043947 |
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author | Ding, Yingying Zhang, Yong Liu, Xuehong |
author_facet | Ding, Yingying Zhang, Yong Liu, Xuehong |
author_sort | Ding, Yingying |
collection | PubMed |
description | Spinocerebellar ataxia (SCA) is an autosomal dominant neurodegenerative disease (ND) with a high mortality rate. Symptomatic treatment is the only clinically adopted treatment. However, it has poor effect and serious complications. Traditional diagnostic methods [such as magnetic resonance imaging (MRI)] have drawbacks. Presently, the superiority of RNA interference (RNAi) and extracellular vesicles (EVs) in improving SCA has attracted extensive attention. Both can serve as the potential biomarkers for the diagnosing and monitoring disease progression. Herein, we analyzed the basis and prospect of therapies for SCA. Meanwhile, we elaborated the development and application of miRNAs, siRNAs, shRNAs, and EVs in the diagnosis and treatment of SCA. We propose the combination of RNAi and EVs to avoid the adverse factors of their respective treatment and maximize the benefits of treatment through the technology of EVs loaded with RNA. Obviously, the combinational therapy of RNAi and EVs may more accurately diagnose and cure SCA. |
format | Online Article Text |
id | pubmed-9606576 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96065762022-10-28 Combinational treatments of RNA interference and extracellular vesicles in the spinocerebellar ataxia Ding, Yingying Zhang, Yong Liu, Xuehong Front Mol Neurosci Molecular Neuroscience Spinocerebellar ataxia (SCA) is an autosomal dominant neurodegenerative disease (ND) with a high mortality rate. Symptomatic treatment is the only clinically adopted treatment. However, it has poor effect and serious complications. Traditional diagnostic methods [such as magnetic resonance imaging (MRI)] have drawbacks. Presently, the superiority of RNA interference (RNAi) and extracellular vesicles (EVs) in improving SCA has attracted extensive attention. Both can serve as the potential biomarkers for the diagnosing and monitoring disease progression. Herein, we analyzed the basis and prospect of therapies for SCA. Meanwhile, we elaborated the development and application of miRNAs, siRNAs, shRNAs, and EVs in the diagnosis and treatment of SCA. We propose the combination of RNAi and EVs to avoid the adverse factors of their respective treatment and maximize the benefits of treatment through the technology of EVs loaded with RNA. Obviously, the combinational therapy of RNAi and EVs may more accurately diagnose and cure SCA. Frontiers Media S.A. 2022-10-13 /pmc/articles/PMC9606576/ /pubmed/36311034 http://dx.doi.org/10.3389/fnmol.2022.1043947 Text en Copyright © 2022 Ding, Zhang and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Neuroscience Ding, Yingying Zhang, Yong Liu, Xuehong Combinational treatments of RNA interference and extracellular vesicles in the spinocerebellar ataxia |
title | Combinational treatments of RNA interference and extracellular vesicles in the spinocerebellar ataxia |
title_full | Combinational treatments of RNA interference and extracellular vesicles in the spinocerebellar ataxia |
title_fullStr | Combinational treatments of RNA interference and extracellular vesicles in the spinocerebellar ataxia |
title_full_unstemmed | Combinational treatments of RNA interference and extracellular vesicles in the spinocerebellar ataxia |
title_short | Combinational treatments of RNA interference and extracellular vesicles in the spinocerebellar ataxia |
title_sort | combinational treatments of rna interference and extracellular vesicles in the spinocerebellar ataxia |
topic | Molecular Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606576/ https://www.ncbi.nlm.nih.gov/pubmed/36311034 http://dx.doi.org/10.3389/fnmol.2022.1043947 |
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