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The causal relationship between abdominal obesity and lower bone mineral density: A two-sample mendelian randomization study
Aims: The purpose of this study was to assess the causal effect of abdominal obesity on bone mineral density by two-sample Mendelian randomization (MR). Methods: Abdominal obesity was chosen as exposure in this study. Single nucleotide polymorphisms, extracted from Genome-wide association analysis (...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606644/ https://www.ncbi.nlm.nih.gov/pubmed/36313427 http://dx.doi.org/10.3389/fgene.2022.970223 |
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author | Wang, Xiang-xuan Lin, Kai-nan Xu, Wen-chen Chen, Hui |
author_facet | Wang, Xiang-xuan Lin, Kai-nan Xu, Wen-chen Chen, Hui |
author_sort | Wang, Xiang-xuan |
collection | PubMed |
description | Aims: The purpose of this study was to assess the causal effect of abdominal obesity on bone mineral density by two-sample Mendelian randomization (MR). Methods: Abdominal obesity was chosen as exposure in this study. Single nucleotide polymorphisms, extracted from Genome-wide association analysis (GWAS) data, which are closely associated with waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR) were used as instrumental variables to perform MR studies. Different site bone mineral density, such as total bone mineral density (TBMD) and forearm bone mineral density (FBMD) were chosen as outcomes. Inverse variance weighted (IVW) was used as the primary method to assess this causality. Results: According to the IVW method (β = −0.177; 95% CI = −0.287, −0.067; p = 1.52 × 10(–3)), WC had a negative causal relationship with TBMD, besides, with one standard deviation (SD) higher in HC, there was a 0.195 SD decrease in TBMD (95% CI = −0.279, −0.110; p = 6.32 × 10(–6)), and with an increase of one SD in HC was related to a decrease of 0.312 SD in FBMD analyzed by the IVW. Conclusion: This study showed that abdominal obesity has a negative effect on bone mineral density. |
format | Online Article Text |
id | pubmed-9606644 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96066442022-10-28 The causal relationship between abdominal obesity and lower bone mineral density: A two-sample mendelian randomization study Wang, Xiang-xuan Lin, Kai-nan Xu, Wen-chen Chen, Hui Front Genet Genetics Aims: The purpose of this study was to assess the causal effect of abdominal obesity on bone mineral density by two-sample Mendelian randomization (MR). Methods: Abdominal obesity was chosen as exposure in this study. Single nucleotide polymorphisms, extracted from Genome-wide association analysis (GWAS) data, which are closely associated with waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR) were used as instrumental variables to perform MR studies. Different site bone mineral density, such as total bone mineral density (TBMD) and forearm bone mineral density (FBMD) were chosen as outcomes. Inverse variance weighted (IVW) was used as the primary method to assess this causality. Results: According to the IVW method (β = −0.177; 95% CI = −0.287, −0.067; p = 1.52 × 10(–3)), WC had a negative causal relationship with TBMD, besides, with one standard deviation (SD) higher in HC, there was a 0.195 SD decrease in TBMD (95% CI = −0.279, −0.110; p = 6.32 × 10(–6)), and with an increase of one SD in HC was related to a decrease of 0.312 SD in FBMD analyzed by the IVW. Conclusion: This study showed that abdominal obesity has a negative effect on bone mineral density. Frontiers Media S.A. 2022-10-13 /pmc/articles/PMC9606644/ /pubmed/36313427 http://dx.doi.org/10.3389/fgene.2022.970223 Text en Copyright © 2022 Wang, Lin, Xu and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Wang, Xiang-xuan Lin, Kai-nan Xu, Wen-chen Chen, Hui The causal relationship between abdominal obesity and lower bone mineral density: A two-sample mendelian randomization study |
title | The causal relationship between abdominal obesity and lower bone mineral density: A two-sample mendelian randomization study |
title_full | The causal relationship between abdominal obesity and lower bone mineral density: A two-sample mendelian randomization study |
title_fullStr | The causal relationship between abdominal obesity and lower bone mineral density: A two-sample mendelian randomization study |
title_full_unstemmed | The causal relationship between abdominal obesity and lower bone mineral density: A two-sample mendelian randomization study |
title_short | The causal relationship between abdominal obesity and lower bone mineral density: A two-sample mendelian randomization study |
title_sort | causal relationship between abdominal obesity and lower bone mineral density: a two-sample mendelian randomization study |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606644/ https://www.ncbi.nlm.nih.gov/pubmed/36313427 http://dx.doi.org/10.3389/fgene.2022.970223 |
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