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Aberrant resting-state functional connectivity and topological properties of the subcortical network in functional dyspepsia patients

Functional dyspepsia (FD) is a disorder of gut-brain interaction. Previous studies have demonstrated a wide range of abnormalities in functional brain activity and connectivity patterns in FD. However, the connectivity pattern of the subcortical network (SCN), which is a hub of visceral information...

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Autores principales: Zhang, Pan, He, Zhaoxuan, Mao, Yangke, Sun, Ruirui, Qu, Yuzhu, Chen, Li, Ma, Peihong, Yin, Shuai, Yin, Tao, Zeng, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606653/
https://www.ncbi.nlm.nih.gov/pubmed/36311019
http://dx.doi.org/10.3389/fnmol.2022.1001557
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author Zhang, Pan
He, Zhaoxuan
Mao, Yangke
Sun, Ruirui
Qu, Yuzhu
Chen, Li
Ma, Peihong
Yin, Shuai
Yin, Tao
Zeng, Fang
author_facet Zhang, Pan
He, Zhaoxuan
Mao, Yangke
Sun, Ruirui
Qu, Yuzhu
Chen, Li
Ma, Peihong
Yin, Shuai
Yin, Tao
Zeng, Fang
author_sort Zhang, Pan
collection PubMed
description Functional dyspepsia (FD) is a disorder of gut-brain interaction. Previous studies have demonstrated a wide range of abnormalities in functional brain activity and connectivity patterns in FD. However, the connectivity pattern of the subcortical network (SCN), which is a hub of visceral information transmission and processing, remains unclear in FD patients. The study compared the resting-state functional connectivity (rsFC) and the global and nodal topological properties of SCN between 109 FD patients and 98 healthy controls, and then explored the correlations between the connectivity metrics and clinical symptoms in FD patients. The results demonstrated that FD patients manifested the increased rsFC in seventeen edges among the SCN, decreased small-worldness and local efficiency in SCN, as well as increased nodal efficiency and nodal degree centrality in the anterior thalamus than healthy controls (p < 0.05, false discovery rate corrected). Moreover, the rsFC of the right anterior thalamus-left nucleus accumbens edge was significantly correlated with the NDSI scores (r = 0.255, p = 0.008, uncorrected) and NDLQI scores (r = −0.241, p = 0.013, uncorrected), the nodal efficiency of right anterior thalamus was significantly correlated with NDLQI scores (r = 0.204, p = 0.036, uncorrected) in FD patients. This study indicated the abnormal rsFC pattern, as well as global and nodal topological properties of the SCN, especially the bilateral anterior thalamus in FD patients, which enhanced our understanding of the central pathophysiology of FD and will lay the foundation for the objective diagnosis of FD and the development of new therapies.
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spelling pubmed-96066532022-10-28 Aberrant resting-state functional connectivity and topological properties of the subcortical network in functional dyspepsia patients Zhang, Pan He, Zhaoxuan Mao, Yangke Sun, Ruirui Qu, Yuzhu Chen, Li Ma, Peihong Yin, Shuai Yin, Tao Zeng, Fang Front Mol Neurosci Molecular Neuroscience Functional dyspepsia (FD) is a disorder of gut-brain interaction. Previous studies have demonstrated a wide range of abnormalities in functional brain activity and connectivity patterns in FD. However, the connectivity pattern of the subcortical network (SCN), which is a hub of visceral information transmission and processing, remains unclear in FD patients. The study compared the resting-state functional connectivity (rsFC) and the global and nodal topological properties of SCN between 109 FD patients and 98 healthy controls, and then explored the correlations between the connectivity metrics and clinical symptoms in FD patients. The results demonstrated that FD patients manifested the increased rsFC in seventeen edges among the SCN, decreased small-worldness and local efficiency in SCN, as well as increased nodal efficiency and nodal degree centrality in the anterior thalamus than healthy controls (p < 0.05, false discovery rate corrected). Moreover, the rsFC of the right anterior thalamus-left nucleus accumbens edge was significantly correlated with the NDSI scores (r = 0.255, p = 0.008, uncorrected) and NDLQI scores (r = −0.241, p = 0.013, uncorrected), the nodal efficiency of right anterior thalamus was significantly correlated with NDLQI scores (r = 0.204, p = 0.036, uncorrected) in FD patients. This study indicated the abnormal rsFC pattern, as well as global and nodal topological properties of the SCN, especially the bilateral anterior thalamus in FD patients, which enhanced our understanding of the central pathophysiology of FD and will lay the foundation for the objective diagnosis of FD and the development of new therapies. Frontiers Media S.A. 2022-10-13 /pmc/articles/PMC9606653/ /pubmed/36311019 http://dx.doi.org/10.3389/fnmol.2022.1001557 Text en Copyright © 2022 Zhang, He, Mao, Sun, Qu, Chen, Ma, Yin, Yin and Zeng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Neuroscience
Zhang, Pan
He, Zhaoxuan
Mao, Yangke
Sun, Ruirui
Qu, Yuzhu
Chen, Li
Ma, Peihong
Yin, Shuai
Yin, Tao
Zeng, Fang
Aberrant resting-state functional connectivity and topological properties of the subcortical network in functional dyspepsia patients
title Aberrant resting-state functional connectivity and topological properties of the subcortical network in functional dyspepsia patients
title_full Aberrant resting-state functional connectivity and topological properties of the subcortical network in functional dyspepsia patients
title_fullStr Aberrant resting-state functional connectivity and topological properties of the subcortical network in functional dyspepsia patients
title_full_unstemmed Aberrant resting-state functional connectivity and topological properties of the subcortical network in functional dyspepsia patients
title_short Aberrant resting-state functional connectivity and topological properties of the subcortical network in functional dyspepsia patients
title_sort aberrant resting-state functional connectivity and topological properties of the subcortical network in functional dyspepsia patients
topic Molecular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606653/
https://www.ncbi.nlm.nih.gov/pubmed/36311019
http://dx.doi.org/10.3389/fnmol.2022.1001557
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