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The role of lncRNAs in regulation of DKD and diabetes-related cancer
Diabetes mellitus often results in several complications, such as diabetic kidney disease (DKD) and end-stage renal diseases (ESRDs). Cancer patients often have the dysregulated glucose metabolism. Abnormal glucose metabolism can enhance the tumor malignant progression. Recently, lncRNAs have been r...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606714/ https://www.ncbi.nlm.nih.gov/pubmed/36313695 http://dx.doi.org/10.3389/fonc.2022.1035487 |
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author | Cheng, Yawei Wu, Xiaowen Xia, Yujie Liu, Wenjun Wang, Peter |
author_facet | Cheng, Yawei Wu, Xiaowen Xia, Yujie Liu, Wenjun Wang, Peter |
author_sort | Cheng, Yawei |
collection | PubMed |
description | Diabetes mellitus often results in several complications, such as diabetic kidney disease (DKD) and end-stage renal diseases (ESRDs). Cancer patients often have the dysregulated glucose metabolism. Abnormal glucose metabolism can enhance the tumor malignant progression. Recently, lncRNAs have been reported to regulate the key proteins and signaling pathways in DKD development and progression and in cancer patients with diabetes. In this review article, we elaborate the evidence to support the function of lncRNAs in development of DKD and diabetes-associated cancer. Moreover, we envisage that lncRNAs could be diagnosis and prognosis biomarkers for DKD and cancer patients with diabetes. Furthermore, we delineated that targeting lncRNAs might be an alternative approach for treating DKD and cancer with dysregulated glucose metabolism. |
format | Online Article Text |
id | pubmed-9606714 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96067142022-10-28 The role of lncRNAs in regulation of DKD and diabetes-related cancer Cheng, Yawei Wu, Xiaowen Xia, Yujie Liu, Wenjun Wang, Peter Front Oncol Oncology Diabetes mellitus often results in several complications, such as diabetic kidney disease (DKD) and end-stage renal diseases (ESRDs). Cancer patients often have the dysregulated glucose metabolism. Abnormal glucose metabolism can enhance the tumor malignant progression. Recently, lncRNAs have been reported to regulate the key proteins and signaling pathways in DKD development and progression and in cancer patients with diabetes. In this review article, we elaborate the evidence to support the function of lncRNAs in development of DKD and diabetes-associated cancer. Moreover, we envisage that lncRNAs could be diagnosis and prognosis biomarkers for DKD and cancer patients with diabetes. Furthermore, we delineated that targeting lncRNAs might be an alternative approach for treating DKD and cancer with dysregulated glucose metabolism. Frontiers Media S.A. 2022-10-13 /pmc/articles/PMC9606714/ /pubmed/36313695 http://dx.doi.org/10.3389/fonc.2022.1035487 Text en Copyright © 2022 Cheng, Wu, Xia, Liu and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Cheng, Yawei Wu, Xiaowen Xia, Yujie Liu, Wenjun Wang, Peter The role of lncRNAs in regulation of DKD and diabetes-related cancer |
title | The role of lncRNAs in regulation of DKD and diabetes-related cancer |
title_full | The role of lncRNAs in regulation of DKD and diabetes-related cancer |
title_fullStr | The role of lncRNAs in regulation of DKD and diabetes-related cancer |
title_full_unstemmed | The role of lncRNAs in regulation of DKD and diabetes-related cancer |
title_short | The role of lncRNAs in regulation of DKD and diabetes-related cancer |
title_sort | role of lncrnas in regulation of dkd and diabetes-related cancer |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606714/ https://www.ncbi.nlm.nih.gov/pubmed/36313695 http://dx.doi.org/10.3389/fonc.2022.1035487 |
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