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The role of lncRNAs in regulation of DKD and diabetes-related cancer

Diabetes mellitus often results in several complications, such as diabetic kidney disease (DKD) and end-stage renal diseases (ESRDs). Cancer patients often have the dysregulated glucose metabolism. Abnormal glucose metabolism can enhance the tumor malignant progression. Recently, lncRNAs have been r...

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Detalles Bibliográficos
Autores principales: Cheng, Yawei, Wu, Xiaowen, Xia, Yujie, Liu, Wenjun, Wang, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606714/
https://www.ncbi.nlm.nih.gov/pubmed/36313695
http://dx.doi.org/10.3389/fonc.2022.1035487
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author Cheng, Yawei
Wu, Xiaowen
Xia, Yujie
Liu, Wenjun
Wang, Peter
author_facet Cheng, Yawei
Wu, Xiaowen
Xia, Yujie
Liu, Wenjun
Wang, Peter
author_sort Cheng, Yawei
collection PubMed
description Diabetes mellitus often results in several complications, such as diabetic kidney disease (DKD) and end-stage renal diseases (ESRDs). Cancer patients often have the dysregulated glucose metabolism. Abnormal glucose metabolism can enhance the tumor malignant progression. Recently, lncRNAs have been reported to regulate the key proteins and signaling pathways in DKD development and progression and in cancer patients with diabetes. In this review article, we elaborate the evidence to support the function of lncRNAs in development of DKD and diabetes-associated cancer. Moreover, we envisage that lncRNAs could be diagnosis and prognosis biomarkers for DKD and cancer patients with diabetes. Furthermore, we delineated that targeting lncRNAs might be an alternative approach for treating DKD and cancer with dysregulated glucose metabolism.
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spelling pubmed-96067142022-10-28 The role of lncRNAs in regulation of DKD and diabetes-related cancer Cheng, Yawei Wu, Xiaowen Xia, Yujie Liu, Wenjun Wang, Peter Front Oncol Oncology Diabetes mellitus often results in several complications, such as diabetic kidney disease (DKD) and end-stage renal diseases (ESRDs). Cancer patients often have the dysregulated glucose metabolism. Abnormal glucose metabolism can enhance the tumor malignant progression. Recently, lncRNAs have been reported to regulate the key proteins and signaling pathways in DKD development and progression and in cancer patients with diabetes. In this review article, we elaborate the evidence to support the function of lncRNAs in development of DKD and diabetes-associated cancer. Moreover, we envisage that lncRNAs could be diagnosis and prognosis biomarkers for DKD and cancer patients with diabetes. Furthermore, we delineated that targeting lncRNAs might be an alternative approach for treating DKD and cancer with dysregulated glucose metabolism. Frontiers Media S.A. 2022-10-13 /pmc/articles/PMC9606714/ /pubmed/36313695 http://dx.doi.org/10.3389/fonc.2022.1035487 Text en Copyright © 2022 Cheng, Wu, Xia, Liu and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Cheng, Yawei
Wu, Xiaowen
Xia, Yujie
Liu, Wenjun
Wang, Peter
The role of lncRNAs in regulation of DKD and diabetes-related cancer
title The role of lncRNAs in regulation of DKD and diabetes-related cancer
title_full The role of lncRNAs in regulation of DKD and diabetes-related cancer
title_fullStr The role of lncRNAs in regulation of DKD and diabetes-related cancer
title_full_unstemmed The role of lncRNAs in regulation of DKD and diabetes-related cancer
title_short The role of lncRNAs in regulation of DKD and diabetes-related cancer
title_sort role of lncrnas in regulation of dkd and diabetes-related cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606714/
https://www.ncbi.nlm.nih.gov/pubmed/36313695
http://dx.doi.org/10.3389/fonc.2022.1035487
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