Hyperglycemia Enhances Immunosuppression and Aerobic Glycolysis of Pancreatic Cancer Through Upregulating Bmi1-UPF1-HK2 Pathway

BACKGROUND & AIMS: Accumulating evidence strongly suggests that hyperglycemia promotes the progression of pancreatic cancer (PC). Approximately 80% of patients with PC are intolerant to hyperglycemic conditions. In this study, we define the role of Bmi1, a stemness-related oncogene, in controlli...

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Detalles Bibliográficos
Autores principales: Wu, Shihong, Zhang, Haoxiang, Gao, Chenggang, Chen, Jiaoshun, Li, Hehe, Meng, Zibo, Bai, Jianwei, Shen, Qiang, Wu, Heshui, Yin, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606831/
https://www.ncbi.nlm.nih.gov/pubmed/35863742
http://dx.doi.org/10.1016/j.jcmgh.2022.07.008

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