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Advanced MXene-Based Micro- and Nanosystems for Targeted Drug Delivery in Cancer Therapy

MXenes with unique mechanical, optical, electronic, and thermal properties along with a specific large surface area for surface functionalization/modification, high electrical conductivity, magnetic properties, biocompatibility, and low toxicity have been explored as attractive candidates for the ta...

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Autores principales: Mohajer, Fatemeh, Ziarani, Ghodsi Mohammadi, Badiei, Alireza, Iravani, Siavash, Varma, Rajender S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606889/
https://www.ncbi.nlm.nih.gov/pubmed/36296126
http://dx.doi.org/10.3390/mi13101773
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author Mohajer, Fatemeh
Ziarani, Ghodsi Mohammadi
Badiei, Alireza
Iravani, Siavash
Varma, Rajender S.
author_facet Mohajer, Fatemeh
Ziarani, Ghodsi Mohammadi
Badiei, Alireza
Iravani, Siavash
Varma, Rajender S.
author_sort Mohajer, Fatemeh
collection PubMed
description MXenes with unique mechanical, optical, electronic, and thermal properties along with a specific large surface area for surface functionalization/modification, high electrical conductivity, magnetic properties, biocompatibility, and low toxicity have been explored as attractive candidates for the targeted delivery of drugs in cancer therapy. These two-dimensional materials have garnered much attention in the field of cancer therapy since they have shown suitable photothermal effects, biocompatibility, and luminescence properties. However, outstanding challenging issues regarding their pharmacokinetics, biosafety, targeting properties, optimized functionalization, synthesis/reaction conditions, and clinical translational studies still need to be addressed. Herein, recent advances and upcoming challenges in the design of advanced targeted drug delivery micro- and nanosystems in cancer therapy using MXenes have been discussed to motivate researchers to further investigate this field of science.
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spelling pubmed-96068892022-10-28 Advanced MXene-Based Micro- and Nanosystems for Targeted Drug Delivery in Cancer Therapy Mohajer, Fatemeh Ziarani, Ghodsi Mohammadi Badiei, Alireza Iravani, Siavash Varma, Rajender S. Micromachines (Basel) Review MXenes with unique mechanical, optical, electronic, and thermal properties along with a specific large surface area for surface functionalization/modification, high electrical conductivity, magnetic properties, biocompatibility, and low toxicity have been explored as attractive candidates for the targeted delivery of drugs in cancer therapy. These two-dimensional materials have garnered much attention in the field of cancer therapy since they have shown suitable photothermal effects, biocompatibility, and luminescence properties. However, outstanding challenging issues regarding their pharmacokinetics, biosafety, targeting properties, optimized functionalization, synthesis/reaction conditions, and clinical translational studies still need to be addressed. Herein, recent advances and upcoming challenges in the design of advanced targeted drug delivery micro- and nanosystems in cancer therapy using MXenes have been discussed to motivate researchers to further investigate this field of science. MDPI 2022-10-19 /pmc/articles/PMC9606889/ /pubmed/36296126 http://dx.doi.org/10.3390/mi13101773 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mohajer, Fatemeh
Ziarani, Ghodsi Mohammadi
Badiei, Alireza
Iravani, Siavash
Varma, Rajender S.
Advanced MXene-Based Micro- and Nanosystems for Targeted Drug Delivery in Cancer Therapy
title Advanced MXene-Based Micro- and Nanosystems for Targeted Drug Delivery in Cancer Therapy
title_full Advanced MXene-Based Micro- and Nanosystems for Targeted Drug Delivery in Cancer Therapy
title_fullStr Advanced MXene-Based Micro- and Nanosystems for Targeted Drug Delivery in Cancer Therapy
title_full_unstemmed Advanced MXene-Based Micro- and Nanosystems for Targeted Drug Delivery in Cancer Therapy
title_short Advanced MXene-Based Micro- and Nanosystems for Targeted Drug Delivery in Cancer Therapy
title_sort advanced mxene-based micro- and nanosystems for targeted drug delivery in cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606889/
https://www.ncbi.nlm.nih.gov/pubmed/36296126
http://dx.doi.org/10.3390/mi13101773
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