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Indole-3-Carbinol Stabilizes p53 to Induce miR-34a, Which Targets LDHA to Block Aerobic Glycolysis in Liver Cancer Cells

Certain cancer cells prefer aerobic glycolysis rather than oxidative phosphorylation for energy supply. Lactate dehydrogenase A (LDHA) catalyzes the reduction of pyruvate to lactate and regains NAD+ so that glycolysis is continued. As a pivotal enzyme to promote smooth glycolysis, LDHA plays an impo...

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Detalles Bibliográficos
Autores principales:	Qi, Yuehua, Zhang, Chunjing, Wu, Di, Zhang, Yue, Zhao, Yunfeng, Li, Wenjuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606903/ https://www.ncbi.nlm.nih.gov/pubmed/36297369 http://dx.doi.org/10.3390/ph15101257

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