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Epileptogenesis and Tumorigenesis in Glioblastoma: Which Relationship?
Epilepsy is reported in 29–52% of patients with glioblastoma (GBM) and has an important role in the natural history of this tumor and patients’ life quality. Although GBM is less epileptogenic than lower-grade gliomas, seizures are usually more difficult to control with common antiseizure medication...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606940/ https://www.ncbi.nlm.nih.gov/pubmed/36295510 http://dx.doi.org/10.3390/medicina58101349 |
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author | Rossi, Jessica Cavallieri, Francesco Biagini, Giuseppe Rizzi, Romana Russo, Marco Cozzi, Salvatore Giaccherini, Lucia Pisanello, Anna Valzania, Franco |
author_facet | Rossi, Jessica Cavallieri, Francesco Biagini, Giuseppe Rizzi, Romana Russo, Marco Cozzi, Salvatore Giaccherini, Lucia Pisanello, Anna Valzania, Franco |
author_sort | Rossi, Jessica |
collection | PubMed |
description | Epilepsy is reported in 29–52% of patients with glioblastoma (GBM) and has an important role in the natural history of this tumor and patients’ life quality. Although GBM is less epileptogenic than lower-grade gliomas, seizures are usually more difficult to control with common antiseizure medications; drug resistance is found in 20% of cases. Recent studies suggest that seizures at the onset of GBM could be a possible favorable independent prognostic factor in patients. Moreover, a growing body of evidence shows that many molecular mechanisms that influence epileptogenesis often regulate GBM growth and invasiveness, sometimes favoring or counteracting the tumor, respectively. The better-characterized players include glutamate, γ-aminobutyric acid, aquaporin-4, and hypoxia-activated molecules. However, currently available data on the molecular basis of epileptogenesis, tumorigenesis, and their relationship is incomplete or discordant and further research is urgently needed on this topic. |
format | Online Article Text |
id | pubmed-9606940 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96069402022-10-28 Epileptogenesis and Tumorigenesis in Glioblastoma: Which Relationship? Rossi, Jessica Cavallieri, Francesco Biagini, Giuseppe Rizzi, Romana Russo, Marco Cozzi, Salvatore Giaccherini, Lucia Pisanello, Anna Valzania, Franco Medicina (Kaunas) Review Epilepsy is reported in 29–52% of patients with glioblastoma (GBM) and has an important role in the natural history of this tumor and patients’ life quality. Although GBM is less epileptogenic than lower-grade gliomas, seizures are usually more difficult to control with common antiseizure medications; drug resistance is found in 20% of cases. Recent studies suggest that seizures at the onset of GBM could be a possible favorable independent prognostic factor in patients. Moreover, a growing body of evidence shows that many molecular mechanisms that influence epileptogenesis often regulate GBM growth and invasiveness, sometimes favoring or counteracting the tumor, respectively. The better-characterized players include glutamate, γ-aminobutyric acid, aquaporin-4, and hypoxia-activated molecules. However, currently available data on the molecular basis of epileptogenesis, tumorigenesis, and their relationship is incomplete or discordant and further research is urgently needed on this topic. MDPI 2022-09-26 /pmc/articles/PMC9606940/ /pubmed/36295510 http://dx.doi.org/10.3390/medicina58101349 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rossi, Jessica Cavallieri, Francesco Biagini, Giuseppe Rizzi, Romana Russo, Marco Cozzi, Salvatore Giaccherini, Lucia Pisanello, Anna Valzania, Franco Epileptogenesis and Tumorigenesis in Glioblastoma: Which Relationship? |
title | Epileptogenesis and Tumorigenesis in Glioblastoma: Which Relationship? |
title_full | Epileptogenesis and Tumorigenesis in Glioblastoma: Which Relationship? |
title_fullStr | Epileptogenesis and Tumorigenesis in Glioblastoma: Which Relationship? |
title_full_unstemmed | Epileptogenesis and Tumorigenesis in Glioblastoma: Which Relationship? |
title_short | Epileptogenesis and Tumorigenesis in Glioblastoma: Which Relationship? |
title_sort | epileptogenesis and tumorigenesis in glioblastoma: which relationship? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606940/ https://www.ncbi.nlm.nih.gov/pubmed/36295510 http://dx.doi.org/10.3390/medicina58101349 |
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