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Epileptogenesis and Tumorigenesis in Glioblastoma: Which Relationship?

Epilepsy is reported in 29–52% of patients with glioblastoma (GBM) and has an important role in the natural history of this tumor and patients’ life quality. Although GBM is less epileptogenic than lower-grade gliomas, seizures are usually more difficult to control with common antiseizure medication...

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Autores principales: Rossi, Jessica, Cavallieri, Francesco, Biagini, Giuseppe, Rizzi, Romana, Russo, Marco, Cozzi, Salvatore, Giaccherini, Lucia, Pisanello, Anna, Valzania, Franco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606940/
https://www.ncbi.nlm.nih.gov/pubmed/36295510
http://dx.doi.org/10.3390/medicina58101349
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author Rossi, Jessica
Cavallieri, Francesco
Biagini, Giuseppe
Rizzi, Romana
Russo, Marco
Cozzi, Salvatore
Giaccherini, Lucia
Pisanello, Anna
Valzania, Franco
author_facet Rossi, Jessica
Cavallieri, Francesco
Biagini, Giuseppe
Rizzi, Romana
Russo, Marco
Cozzi, Salvatore
Giaccherini, Lucia
Pisanello, Anna
Valzania, Franco
author_sort Rossi, Jessica
collection PubMed
description Epilepsy is reported in 29–52% of patients with glioblastoma (GBM) and has an important role in the natural history of this tumor and patients’ life quality. Although GBM is less epileptogenic than lower-grade gliomas, seizures are usually more difficult to control with common antiseizure medications; drug resistance is found in 20% of cases. Recent studies suggest that seizures at the onset of GBM could be a possible favorable independent prognostic factor in patients. Moreover, a growing body of evidence shows that many molecular mechanisms that influence epileptogenesis often regulate GBM growth and invasiveness, sometimes favoring or counteracting the tumor, respectively. The better-characterized players include glutamate, γ-aminobutyric acid, aquaporin-4, and hypoxia-activated molecules. However, currently available data on the molecular basis of epileptogenesis, tumorigenesis, and their relationship is incomplete or discordant and further research is urgently needed on this topic.
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spelling pubmed-96069402022-10-28 Epileptogenesis and Tumorigenesis in Glioblastoma: Which Relationship? Rossi, Jessica Cavallieri, Francesco Biagini, Giuseppe Rizzi, Romana Russo, Marco Cozzi, Salvatore Giaccherini, Lucia Pisanello, Anna Valzania, Franco Medicina (Kaunas) Review Epilepsy is reported in 29–52% of patients with glioblastoma (GBM) and has an important role in the natural history of this tumor and patients’ life quality. Although GBM is less epileptogenic than lower-grade gliomas, seizures are usually more difficult to control with common antiseizure medications; drug resistance is found in 20% of cases. Recent studies suggest that seizures at the onset of GBM could be a possible favorable independent prognostic factor in patients. Moreover, a growing body of evidence shows that many molecular mechanisms that influence epileptogenesis often regulate GBM growth and invasiveness, sometimes favoring or counteracting the tumor, respectively. The better-characterized players include glutamate, γ-aminobutyric acid, aquaporin-4, and hypoxia-activated molecules. However, currently available data on the molecular basis of epileptogenesis, tumorigenesis, and their relationship is incomplete or discordant and further research is urgently needed on this topic. MDPI 2022-09-26 /pmc/articles/PMC9606940/ /pubmed/36295510 http://dx.doi.org/10.3390/medicina58101349 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rossi, Jessica
Cavallieri, Francesco
Biagini, Giuseppe
Rizzi, Romana
Russo, Marco
Cozzi, Salvatore
Giaccherini, Lucia
Pisanello, Anna
Valzania, Franco
Epileptogenesis and Tumorigenesis in Glioblastoma: Which Relationship?
title Epileptogenesis and Tumorigenesis in Glioblastoma: Which Relationship?
title_full Epileptogenesis and Tumorigenesis in Glioblastoma: Which Relationship?
title_fullStr Epileptogenesis and Tumorigenesis in Glioblastoma: Which Relationship?
title_full_unstemmed Epileptogenesis and Tumorigenesis in Glioblastoma: Which Relationship?
title_short Epileptogenesis and Tumorigenesis in Glioblastoma: Which Relationship?
title_sort epileptogenesis and tumorigenesis in glioblastoma: which relationship?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606940/
https://www.ncbi.nlm.nih.gov/pubmed/36295510
http://dx.doi.org/10.3390/medicina58101349
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