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Clinical Value of Diffusion-Weighted Whole-Body Imaging with Background Body Signal Suppression (DWIBS) for Staging of Patients with Suspected Head and Neck Cancer

(1) Background: To determine the importance of diffusion-weighted whole-body MRI with background body signal suppression (DWIBS) in the staging process of patients with suspected head and neck carcinomas. (2) Methods: A total of 30 patients (24 male, 6 female) with a median age of 67 years with clin...

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Autores principales: Schicho, Andreas, Habicher, Werner, Wendl, Christina, Stroszczynski, Christian, Strotzer, Quirin, Dollinger, Marco, Schreyer, Andreas G., Schleder, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607011/
https://www.ncbi.nlm.nih.gov/pubmed/36287809
http://dx.doi.org/10.3390/tomography8050210
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author Schicho, Andreas
Habicher, Werner
Wendl, Christina
Stroszczynski, Christian
Strotzer, Quirin
Dollinger, Marco
Schreyer, Andreas G.
Schleder, Stephan
author_facet Schicho, Andreas
Habicher, Werner
Wendl, Christina
Stroszczynski, Christian
Strotzer, Quirin
Dollinger, Marco
Schreyer, Andreas G.
Schleder, Stephan
author_sort Schicho, Andreas
collection PubMed
description (1) Background: To determine the importance of diffusion-weighted whole-body MRI with background body signal suppression (DWIBS) in the staging process of patients with suspected head and neck carcinomas. (2) Methods: A total of 30 patients (24 male, 6 female) with a median age of 67 years with clinically suspected head and neck carcinoma with pathologic cervical nodal swelling in ultrasound underwent the staging procedure with computed tomography (CT) and whole-body MRI including DWIBS. (3) Results: In a total of 9 patients, abnormalities in the routine work-up of pretherapeutic staging were found. Five cases of either secondary cancer or distant metastases were only visible in DWIBS, while being missed on CT. One diagnosis was only detectable in CT and not in DWIBS, whereas three diagnoses were recognizable in both modalities. (4) Conclusions: DWIBS in addition to a standard neck MRI in cervical lymphadenopathy suspicious for head and neck cancer yielded additional clinically relevant diagnoses in 17% of cases that would have been missed by current staging routine procedures. DWIBS offered a negative predictive value of 98.78% for ruling out distant metastases or secondary malignancies.
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spelling pubmed-96070112022-10-28 Clinical Value of Diffusion-Weighted Whole-Body Imaging with Background Body Signal Suppression (DWIBS) for Staging of Patients with Suspected Head and Neck Cancer Schicho, Andreas Habicher, Werner Wendl, Christina Stroszczynski, Christian Strotzer, Quirin Dollinger, Marco Schreyer, Andreas G. Schleder, Stephan Tomography Article (1) Background: To determine the importance of diffusion-weighted whole-body MRI with background body signal suppression (DWIBS) in the staging process of patients with suspected head and neck carcinomas. (2) Methods: A total of 30 patients (24 male, 6 female) with a median age of 67 years with clinically suspected head and neck carcinoma with pathologic cervical nodal swelling in ultrasound underwent the staging procedure with computed tomography (CT) and whole-body MRI including DWIBS. (3) Results: In a total of 9 patients, abnormalities in the routine work-up of pretherapeutic staging were found. Five cases of either secondary cancer or distant metastases were only visible in DWIBS, while being missed on CT. One diagnosis was only detectable in CT and not in DWIBS, whereas three diagnoses were recognizable in both modalities. (4) Conclusions: DWIBS in addition to a standard neck MRI in cervical lymphadenopathy suspicious for head and neck cancer yielded additional clinically relevant diagnoses in 17% of cases that would have been missed by current staging routine procedures. DWIBS offered a negative predictive value of 98.78% for ruling out distant metastases or secondary malignancies. MDPI 2022-10-09 /pmc/articles/PMC9607011/ /pubmed/36287809 http://dx.doi.org/10.3390/tomography8050210 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schicho, Andreas
Habicher, Werner
Wendl, Christina
Stroszczynski, Christian
Strotzer, Quirin
Dollinger, Marco
Schreyer, Andreas G.
Schleder, Stephan
Clinical Value of Diffusion-Weighted Whole-Body Imaging with Background Body Signal Suppression (DWIBS) for Staging of Patients with Suspected Head and Neck Cancer
title Clinical Value of Diffusion-Weighted Whole-Body Imaging with Background Body Signal Suppression (DWIBS) for Staging of Patients with Suspected Head and Neck Cancer
title_full Clinical Value of Diffusion-Weighted Whole-Body Imaging with Background Body Signal Suppression (DWIBS) for Staging of Patients with Suspected Head and Neck Cancer
title_fullStr Clinical Value of Diffusion-Weighted Whole-Body Imaging with Background Body Signal Suppression (DWIBS) for Staging of Patients with Suspected Head and Neck Cancer
title_full_unstemmed Clinical Value of Diffusion-Weighted Whole-Body Imaging with Background Body Signal Suppression (DWIBS) for Staging of Patients with Suspected Head and Neck Cancer
title_short Clinical Value of Diffusion-Weighted Whole-Body Imaging with Background Body Signal Suppression (DWIBS) for Staging of Patients with Suspected Head and Neck Cancer
title_sort clinical value of diffusion-weighted whole-body imaging with background body signal suppression (dwibs) for staging of patients with suspected head and neck cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607011/
https://www.ncbi.nlm.nih.gov/pubmed/36287809
http://dx.doi.org/10.3390/tomography8050210
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