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The Use of Photodynamic Therapy in the Treatment of Brain Tumors—A Review of the Literature

The treatment of neoplastic disease of the brain is still a challenge for modern medicine. Therefore, advanced methodologies are needed that can rationally and successfully contribute to the early diagnosis of primary and metastatic tumors growing within the brain. Photodynamic therapy (PDT) seems t...

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Autores principales: Bartusik-Aebisher, Dorota, Żołyniak, Aleksandra, Barnaś, Edyta, Machorowska-Pieniążek, Agnieszka, Oleś, Piotr, Kawczyk-Krupka, Aleksandra, Aebisher, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607067/
https://www.ncbi.nlm.nih.gov/pubmed/36296440
http://dx.doi.org/10.3390/molecules27206847
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author Bartusik-Aebisher, Dorota
Żołyniak, Aleksandra
Barnaś, Edyta
Machorowska-Pieniążek, Agnieszka
Oleś, Piotr
Kawczyk-Krupka, Aleksandra
Aebisher, David
author_facet Bartusik-Aebisher, Dorota
Żołyniak, Aleksandra
Barnaś, Edyta
Machorowska-Pieniążek, Agnieszka
Oleś, Piotr
Kawczyk-Krupka, Aleksandra
Aebisher, David
author_sort Bartusik-Aebisher, Dorota
collection PubMed
description The treatment of neoplastic disease of the brain is still a challenge for modern medicine. Therefore, advanced methodologies are needed that can rationally and successfully contribute to the early diagnosis of primary and metastatic tumors growing within the brain. Photodynamic therapy (PDT) seems to be a valuable method of treatment for precancerous and cancerous lesions including brain tumors. The main advantage of PDT is its high efficiency, minimal invasiveness and no serious side effects, compared with chemotherapy and radiotherapy. This review was conducted through a comprehensive search of articles, scientific information databases and the websites of organizations dealing with cancer treatment. Key points from clinical trials conducted by other researchers are also discussed. The common databases such as PubMed, Google Scholar, EBSCO, Scopus, and Elsevier were used. Articles in the English language of reliable credibility were mainly analyzed. The type of publications considered included clinical and preclinical studies, systematic reviews, and case reports. Based on these collected materials, we see that scientists have already demonstrated the potential of PDT application in the field of brain tumors. Therefore, in this review, the treatment of neoplasm of the Central Nervous System (CNS) and the most common tumor, glioblastoma multiforme (GBM), have been explored. In addition, an overview of the general principles of PDT, as well as the mechanism of action of the therapy as a therapeutic platform for brain tumors, is described. The research was carried out in June 2022.
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spelling pubmed-96070672022-10-28 The Use of Photodynamic Therapy in the Treatment of Brain Tumors—A Review of the Literature Bartusik-Aebisher, Dorota Żołyniak, Aleksandra Barnaś, Edyta Machorowska-Pieniążek, Agnieszka Oleś, Piotr Kawczyk-Krupka, Aleksandra Aebisher, David Molecules Review The treatment of neoplastic disease of the brain is still a challenge for modern medicine. Therefore, advanced methodologies are needed that can rationally and successfully contribute to the early diagnosis of primary and metastatic tumors growing within the brain. Photodynamic therapy (PDT) seems to be a valuable method of treatment for precancerous and cancerous lesions including brain tumors. The main advantage of PDT is its high efficiency, minimal invasiveness and no serious side effects, compared with chemotherapy and radiotherapy. This review was conducted through a comprehensive search of articles, scientific information databases and the websites of organizations dealing with cancer treatment. Key points from clinical trials conducted by other researchers are also discussed. The common databases such as PubMed, Google Scholar, EBSCO, Scopus, and Elsevier were used. Articles in the English language of reliable credibility were mainly analyzed. The type of publications considered included clinical and preclinical studies, systematic reviews, and case reports. Based on these collected materials, we see that scientists have already demonstrated the potential of PDT application in the field of brain tumors. Therefore, in this review, the treatment of neoplasm of the Central Nervous System (CNS) and the most common tumor, glioblastoma multiforme (GBM), have been explored. In addition, an overview of the general principles of PDT, as well as the mechanism of action of the therapy as a therapeutic platform for brain tumors, is described. The research was carried out in June 2022. MDPI 2022-10-13 /pmc/articles/PMC9607067/ /pubmed/36296440 http://dx.doi.org/10.3390/molecules27206847 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bartusik-Aebisher, Dorota
Żołyniak, Aleksandra
Barnaś, Edyta
Machorowska-Pieniążek, Agnieszka
Oleś, Piotr
Kawczyk-Krupka, Aleksandra
Aebisher, David
The Use of Photodynamic Therapy in the Treatment of Brain Tumors—A Review of the Literature
title The Use of Photodynamic Therapy in the Treatment of Brain Tumors—A Review of the Literature
title_full The Use of Photodynamic Therapy in the Treatment of Brain Tumors—A Review of the Literature
title_fullStr The Use of Photodynamic Therapy in the Treatment of Brain Tumors—A Review of the Literature
title_full_unstemmed The Use of Photodynamic Therapy in the Treatment of Brain Tumors—A Review of the Literature
title_short The Use of Photodynamic Therapy in the Treatment of Brain Tumors—A Review of the Literature
title_sort use of photodynamic therapy in the treatment of brain tumors—a review of the literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607067/
https://www.ncbi.nlm.nih.gov/pubmed/36296440
http://dx.doi.org/10.3390/molecules27206847
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