Cargando…
Polymeric Nanoparticles for Inhaled Vaccines
Many recent studies focus on the pulmonary delivery of vaccines as it is needle-free, safe, and effective. Inhaled vaccines enhance systemic and mucosal immunization but still faces many limitations that can be resolved using polymeric nanoparticles (PNPs). This review focuses on the use of properti...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607145/ https://www.ncbi.nlm.nih.gov/pubmed/36298030 http://dx.doi.org/10.3390/polym14204450 |
_version_ | 1784818468785225728 |
---|---|
author | Al-Nemrawi, Nusaiba K. Darweesh, Ruba S. Al-shriem, Lubna A. Al-Qawasmi, Farah S. Emran, Sereen O. Khafajah, Areej S. Abu-Dalo, Muna A. |
author_facet | Al-Nemrawi, Nusaiba K. Darweesh, Ruba S. Al-shriem, Lubna A. Al-Qawasmi, Farah S. Emran, Sereen O. Khafajah, Areej S. Abu-Dalo, Muna A. |
author_sort | Al-Nemrawi, Nusaiba K. |
collection | PubMed |
description | Many recent studies focus on the pulmonary delivery of vaccines as it is needle-free, safe, and effective. Inhaled vaccines enhance systemic and mucosal immunization but still faces many limitations that can be resolved using polymeric nanoparticles (PNPs). This review focuses on the use of properties of PNPs, specifically chitosan and PLGA to be used in the delivery of vaccines by inhalation. It also aims to highlight that PNPs have adjuvant properties by themselves that induce cellular and humeral immunogenicity. Further, different factors influence the behavior of PNP in vivo such as size, morphology, and charge are discussed. Finally, some of the primary challenges facing PNPs are reviewed including formulation instability, reproducibility, device-related factors, patient-related factors, and industrial-level scale-up. Herein, the most important variables of PNPs that shall be defined in any PNPs to be used for pulmonary delivery are defined. Further, this study focuses on the most popular polymers used for this purpose. |
format | Online Article Text |
id | pubmed-9607145 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96071452022-10-28 Polymeric Nanoparticles for Inhaled Vaccines Al-Nemrawi, Nusaiba K. Darweesh, Ruba S. Al-shriem, Lubna A. Al-Qawasmi, Farah S. Emran, Sereen O. Khafajah, Areej S. Abu-Dalo, Muna A. Polymers (Basel) Review Many recent studies focus on the pulmonary delivery of vaccines as it is needle-free, safe, and effective. Inhaled vaccines enhance systemic and mucosal immunization but still faces many limitations that can be resolved using polymeric nanoparticles (PNPs). This review focuses on the use of properties of PNPs, specifically chitosan and PLGA to be used in the delivery of vaccines by inhalation. It also aims to highlight that PNPs have adjuvant properties by themselves that induce cellular and humeral immunogenicity. Further, different factors influence the behavior of PNP in vivo such as size, morphology, and charge are discussed. Finally, some of the primary challenges facing PNPs are reviewed including formulation instability, reproducibility, device-related factors, patient-related factors, and industrial-level scale-up. Herein, the most important variables of PNPs that shall be defined in any PNPs to be used for pulmonary delivery are defined. Further, this study focuses on the most popular polymers used for this purpose. MDPI 2022-10-21 /pmc/articles/PMC9607145/ /pubmed/36298030 http://dx.doi.org/10.3390/polym14204450 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Al-Nemrawi, Nusaiba K. Darweesh, Ruba S. Al-shriem, Lubna A. Al-Qawasmi, Farah S. Emran, Sereen O. Khafajah, Areej S. Abu-Dalo, Muna A. Polymeric Nanoparticles for Inhaled Vaccines |
title | Polymeric Nanoparticles for Inhaled Vaccines |
title_full | Polymeric Nanoparticles for Inhaled Vaccines |
title_fullStr | Polymeric Nanoparticles for Inhaled Vaccines |
title_full_unstemmed | Polymeric Nanoparticles for Inhaled Vaccines |
title_short | Polymeric Nanoparticles for Inhaled Vaccines |
title_sort | polymeric nanoparticles for inhaled vaccines |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607145/ https://www.ncbi.nlm.nih.gov/pubmed/36298030 http://dx.doi.org/10.3390/polym14204450 |
work_keys_str_mv | AT alnemrawinusaibak polymericnanoparticlesforinhaledvaccines AT darweeshrubas polymericnanoparticlesforinhaledvaccines AT alshriemlubnaa polymericnanoparticlesforinhaledvaccines AT alqawasmifarahs polymericnanoparticlesforinhaledvaccines AT emransereeno polymericnanoparticlesforinhaledvaccines AT khafajahareejs polymericnanoparticlesforinhaledvaccines AT abudalomunaa polymericnanoparticlesforinhaledvaccines |