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Polymeric Nanoparticles for Inhaled Vaccines

Many recent studies focus on the pulmonary delivery of vaccines as it is needle-free, safe, and effective. Inhaled vaccines enhance systemic and mucosal immunization but still faces many limitations that can be resolved using polymeric nanoparticles (PNPs). This review focuses on the use of properti...

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Autores principales: Al-Nemrawi, Nusaiba K., Darweesh, Ruba S., Al-shriem, Lubna A., Al-Qawasmi, Farah S., Emran, Sereen O., Khafajah, Areej S., Abu-Dalo, Muna A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607145/
https://www.ncbi.nlm.nih.gov/pubmed/36298030
http://dx.doi.org/10.3390/polym14204450
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author Al-Nemrawi, Nusaiba K.
Darweesh, Ruba S.
Al-shriem, Lubna A.
Al-Qawasmi, Farah S.
Emran, Sereen O.
Khafajah, Areej S.
Abu-Dalo, Muna A.
author_facet Al-Nemrawi, Nusaiba K.
Darweesh, Ruba S.
Al-shriem, Lubna A.
Al-Qawasmi, Farah S.
Emran, Sereen O.
Khafajah, Areej S.
Abu-Dalo, Muna A.
author_sort Al-Nemrawi, Nusaiba K.
collection PubMed
description Many recent studies focus on the pulmonary delivery of vaccines as it is needle-free, safe, and effective. Inhaled vaccines enhance systemic and mucosal immunization but still faces many limitations that can be resolved using polymeric nanoparticles (PNPs). This review focuses on the use of properties of PNPs, specifically chitosan and PLGA to be used in the delivery of vaccines by inhalation. It also aims to highlight that PNPs have adjuvant properties by themselves that induce cellular and humeral immunogenicity. Further, different factors influence the behavior of PNP in vivo such as size, morphology, and charge are discussed. Finally, some of the primary challenges facing PNPs are reviewed including formulation instability, reproducibility, device-related factors, patient-related factors, and industrial-level scale-up. Herein, the most important variables of PNPs that shall be defined in any PNPs to be used for pulmonary delivery are defined. Further, this study focuses on the most popular polymers used for this purpose.
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spelling pubmed-96071452022-10-28 Polymeric Nanoparticles for Inhaled Vaccines Al-Nemrawi, Nusaiba K. Darweesh, Ruba S. Al-shriem, Lubna A. Al-Qawasmi, Farah S. Emran, Sereen O. Khafajah, Areej S. Abu-Dalo, Muna A. Polymers (Basel) Review Many recent studies focus on the pulmonary delivery of vaccines as it is needle-free, safe, and effective. Inhaled vaccines enhance systemic and mucosal immunization but still faces many limitations that can be resolved using polymeric nanoparticles (PNPs). This review focuses on the use of properties of PNPs, specifically chitosan and PLGA to be used in the delivery of vaccines by inhalation. It also aims to highlight that PNPs have adjuvant properties by themselves that induce cellular and humeral immunogenicity. Further, different factors influence the behavior of PNP in vivo such as size, morphology, and charge are discussed. Finally, some of the primary challenges facing PNPs are reviewed including formulation instability, reproducibility, device-related factors, patient-related factors, and industrial-level scale-up. Herein, the most important variables of PNPs that shall be defined in any PNPs to be used for pulmonary delivery are defined. Further, this study focuses on the most popular polymers used for this purpose. MDPI 2022-10-21 /pmc/articles/PMC9607145/ /pubmed/36298030 http://dx.doi.org/10.3390/polym14204450 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Al-Nemrawi, Nusaiba K.
Darweesh, Ruba S.
Al-shriem, Lubna A.
Al-Qawasmi, Farah S.
Emran, Sereen O.
Khafajah, Areej S.
Abu-Dalo, Muna A.
Polymeric Nanoparticles for Inhaled Vaccines
title Polymeric Nanoparticles for Inhaled Vaccines
title_full Polymeric Nanoparticles for Inhaled Vaccines
title_fullStr Polymeric Nanoparticles for Inhaled Vaccines
title_full_unstemmed Polymeric Nanoparticles for Inhaled Vaccines
title_short Polymeric Nanoparticles for Inhaled Vaccines
title_sort polymeric nanoparticles for inhaled vaccines
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607145/
https://www.ncbi.nlm.nih.gov/pubmed/36298030
http://dx.doi.org/10.3390/polym14204450
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