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Allergic Disorders and Risk of Anemia in Japanese Children: Findings from the Japan Environment and Children’s Study

Previous epidemiological studies have reported an increased risk of anemia in people with allergic disorders. However, previous studies have followed a cross-sectional design. The aim of this study was to investigate the association between the two conditions with a cohort dataset. We used data of 8...

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Autores principales: Yang, Limin, Sato, Miori, Saito-Abe, Mayako, Miyaji, Yumiko, Shimada, Mami, Sato, Chikako, Nishizato, Minaho, Kumasaka, Natsuhiko, Mezawa, Hidetoshi, Yamamoto-Hanada, Kiwako, Ohya, Yukihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607270/
https://www.ncbi.nlm.nih.gov/pubmed/36297019
http://dx.doi.org/10.3390/nu14204335
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author Yang, Limin
Sato, Miori
Saito-Abe, Mayako
Miyaji, Yumiko
Shimada, Mami
Sato, Chikako
Nishizato, Minaho
Kumasaka, Natsuhiko
Mezawa, Hidetoshi
Yamamoto-Hanada, Kiwako
Ohya, Yukihiro
author_facet Yang, Limin
Sato, Miori
Saito-Abe, Mayako
Miyaji, Yumiko
Shimada, Mami
Sato, Chikako
Nishizato, Minaho
Kumasaka, Natsuhiko
Mezawa, Hidetoshi
Yamamoto-Hanada, Kiwako
Ohya, Yukihiro
author_sort Yang, Limin
collection PubMed
description Previous epidemiological studies have reported an increased risk of anemia in people with allergic disorders. However, previous studies have followed a cross-sectional design. The aim of this study was to investigate the association between the two conditions with a cohort dataset. We used data of 80,943 children in the Japan Environment and Children’s Study, the largest birth cohort in Japan. The association between anemia and allergic disorders was evaluated with a logistic regression model and propensity score analysis. After adjusting for potential confounders, children with asthma (odds ratio [OR], 1.85; 95% confidence interval [CI], 1.32–2.60), atopic dermatitis (OR, 2.18; 95% CI, 1.66–2.85), allergic rhinitis (OR, 1.35; 95% CI, 1.05–1.74), allergic rhinoconjunctivitis (OR, 2.95; 95% CI, 1.91–4.54), and food allergies (OR, 1.92; 95% CI, 1.44–2.56) at 2 years of age predicted high odds of developing anemia in the next year. Any allergy at 2 years of age was associated with an increased risk of anemia at the age of 3 years (OR, 1.80; 95% CI, 1.41–2.29). The findings remained stable in the propensity score analysis. Results suggest that allergic diseases were related to caregiver-reported anemia in children.
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spelling pubmed-96072702022-10-28 Allergic Disorders and Risk of Anemia in Japanese Children: Findings from the Japan Environment and Children’s Study Yang, Limin Sato, Miori Saito-Abe, Mayako Miyaji, Yumiko Shimada, Mami Sato, Chikako Nishizato, Minaho Kumasaka, Natsuhiko Mezawa, Hidetoshi Yamamoto-Hanada, Kiwako Ohya, Yukihiro Nutrients Article Previous epidemiological studies have reported an increased risk of anemia in people with allergic disorders. However, previous studies have followed a cross-sectional design. The aim of this study was to investigate the association between the two conditions with a cohort dataset. We used data of 80,943 children in the Japan Environment and Children’s Study, the largest birth cohort in Japan. The association between anemia and allergic disorders was evaluated with a logistic regression model and propensity score analysis. After adjusting for potential confounders, children with asthma (odds ratio [OR], 1.85; 95% confidence interval [CI], 1.32–2.60), atopic dermatitis (OR, 2.18; 95% CI, 1.66–2.85), allergic rhinitis (OR, 1.35; 95% CI, 1.05–1.74), allergic rhinoconjunctivitis (OR, 2.95; 95% CI, 1.91–4.54), and food allergies (OR, 1.92; 95% CI, 1.44–2.56) at 2 years of age predicted high odds of developing anemia in the next year. Any allergy at 2 years of age was associated with an increased risk of anemia at the age of 3 years (OR, 1.80; 95% CI, 1.41–2.29). The findings remained stable in the propensity score analysis. Results suggest that allergic diseases were related to caregiver-reported anemia in children. MDPI 2022-10-17 /pmc/articles/PMC9607270/ /pubmed/36297019 http://dx.doi.org/10.3390/nu14204335 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yang, Limin
Sato, Miori
Saito-Abe, Mayako
Miyaji, Yumiko
Shimada, Mami
Sato, Chikako
Nishizato, Minaho
Kumasaka, Natsuhiko
Mezawa, Hidetoshi
Yamamoto-Hanada, Kiwako
Ohya, Yukihiro
Allergic Disorders and Risk of Anemia in Japanese Children: Findings from the Japan Environment and Children’s Study
title Allergic Disorders and Risk of Anemia in Japanese Children: Findings from the Japan Environment and Children’s Study
title_full Allergic Disorders and Risk of Anemia in Japanese Children: Findings from the Japan Environment and Children’s Study
title_fullStr Allergic Disorders and Risk of Anemia in Japanese Children: Findings from the Japan Environment and Children’s Study
title_full_unstemmed Allergic Disorders and Risk of Anemia in Japanese Children: Findings from the Japan Environment and Children’s Study
title_short Allergic Disorders and Risk of Anemia in Japanese Children: Findings from the Japan Environment and Children’s Study
title_sort allergic disorders and risk of anemia in japanese children: findings from the japan environment and children’s study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607270/
https://www.ncbi.nlm.nih.gov/pubmed/36297019
http://dx.doi.org/10.3390/nu14204335
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