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Effects of Carbon Nanomaterials and Aloe vera on Melanomas—Where Are We? Recent Updates

Melanoma is an aggressive skin cancer that affects approximately 140,000 people worldwide each year, with a high fatality rate. Available treatment modalities show limited efficacy in more severe cases. Hence, the search for new treatment modalities, including immunotherapies, for curing, mitigating...

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Autores principales: de Carvalho Lima, Elidamar Nunes, Barros Martins, Guilherme Leão, Diaz, Ricardo Sobhie, Schechter, Mauro, Piqueira, José Roberto Castilho, Justo, João Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607275/
https://www.ncbi.nlm.nih.gov/pubmed/36297440
http://dx.doi.org/10.3390/pharmaceutics14102004
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author de Carvalho Lima, Elidamar Nunes
Barros Martins, Guilherme Leão
Diaz, Ricardo Sobhie
Schechter, Mauro
Piqueira, José Roberto Castilho
Justo, João Francisco
author_facet de Carvalho Lima, Elidamar Nunes
Barros Martins, Guilherme Leão
Diaz, Ricardo Sobhie
Schechter, Mauro
Piqueira, José Roberto Castilho
Justo, João Francisco
author_sort de Carvalho Lima, Elidamar Nunes
collection PubMed
description Melanoma is an aggressive skin cancer that affects approximately 140,000 people worldwide each year, with a high fatality rate. Available treatment modalities show limited efficacy in more severe cases. Hence, the search for new treatment modalities, including immunotherapies, for curing, mitigating, and/or preventing cancer is important and urgently needed. Carbon nanoparticles associated with some plant materials, such as Aloe vera, have shown appealing antineoplastic activity, derived mainly from the compounds aloin, aloe-emodin, barbaloin acemannan, and octapeptide, thus representing new possibilities as antitumor agents. This systematic review aims to arouse interest and present the possibilities of using Aloe vera combined with carbon-based nanomaterials as an antineoplastic agent in the treatment and prevention of melanoma. Limitations and advances in melanoma treatment using functionalized carbon nanomaterials are discussed here. Moreover, this review provides the basis for further studies designed to fully explore the potential of carbon nanomaterials associated with Aloe vera in the treatment of various cancers, with a focus on melanoma.
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spelling pubmed-96072752022-10-28 Effects of Carbon Nanomaterials and Aloe vera on Melanomas—Where Are We? Recent Updates de Carvalho Lima, Elidamar Nunes Barros Martins, Guilherme Leão Diaz, Ricardo Sobhie Schechter, Mauro Piqueira, José Roberto Castilho Justo, João Francisco Pharmaceutics Review Melanoma is an aggressive skin cancer that affects approximately 140,000 people worldwide each year, with a high fatality rate. Available treatment modalities show limited efficacy in more severe cases. Hence, the search for new treatment modalities, including immunotherapies, for curing, mitigating, and/or preventing cancer is important and urgently needed. Carbon nanoparticles associated with some plant materials, such as Aloe vera, have shown appealing antineoplastic activity, derived mainly from the compounds aloin, aloe-emodin, barbaloin acemannan, and octapeptide, thus representing new possibilities as antitumor agents. This systematic review aims to arouse interest and present the possibilities of using Aloe vera combined with carbon-based nanomaterials as an antineoplastic agent in the treatment and prevention of melanoma. Limitations and advances in melanoma treatment using functionalized carbon nanomaterials are discussed here. Moreover, this review provides the basis for further studies designed to fully explore the potential of carbon nanomaterials associated with Aloe vera in the treatment of various cancers, with a focus on melanoma. MDPI 2022-09-22 /pmc/articles/PMC9607275/ /pubmed/36297440 http://dx.doi.org/10.3390/pharmaceutics14102004 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
de Carvalho Lima, Elidamar Nunes
Barros Martins, Guilherme Leão
Diaz, Ricardo Sobhie
Schechter, Mauro
Piqueira, José Roberto Castilho
Justo, João Francisco
Effects of Carbon Nanomaterials and Aloe vera on Melanomas—Where Are We? Recent Updates
title Effects of Carbon Nanomaterials and Aloe vera on Melanomas—Where Are We? Recent Updates
title_full Effects of Carbon Nanomaterials and Aloe vera on Melanomas—Where Are We? Recent Updates
title_fullStr Effects of Carbon Nanomaterials and Aloe vera on Melanomas—Where Are We? Recent Updates
title_full_unstemmed Effects of Carbon Nanomaterials and Aloe vera on Melanomas—Where Are We? Recent Updates
title_short Effects of Carbon Nanomaterials and Aloe vera on Melanomas—Where Are We? Recent Updates
title_sort effects of carbon nanomaterials and aloe vera on melanomas—where are we? recent updates
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607275/
https://www.ncbi.nlm.nih.gov/pubmed/36297440
http://dx.doi.org/10.3390/pharmaceutics14102004
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