Enantioselective, Decarboxylative (3+2)-Cycloaddition of Azomethine Ylides and Chromone-3-Carboxylic Acids

Herein, we describe the synthesis of a variety of chiral hybrid pyrrolidine-chromanone polycyclic derivatives. A convenient (3+2)-annulation of azomethine ylides with chromone-3-carboxylic acid realized under Brønsted base catalysis produced highly functionalized products in high yields with good st...

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Detalles Bibliográficos
Autores principales: Kowalska, Ewelina, Sieroń, Lesław, Albrecht, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607314/
https://www.ncbi.nlm.nih.gov/pubmed/36296402
http://dx.doi.org/10.3390/molecules27206809
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author Kowalska, Ewelina
Sieroń, Lesław
Albrecht, Anna
author_facet Kowalska, Ewelina
Sieroń, Lesław
Albrecht, Anna
author_sort Kowalska, Ewelina
collection PubMed
description Herein, we describe the synthesis of a variety of chiral hybrid pyrrolidine-chromanone polycyclic derivatives. A convenient (3+2)-annulation of azomethine ylides with chromone-3-carboxylic acid realized under Brønsted base catalysis produced highly functionalized products in high yields with good stereoselectivities through asymmetric, intermolecular, and decarboxylative (3+2)-cyclization.
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spelling pubmed-96073142022-10-28 Enantioselective, Decarboxylative (3+2)-Cycloaddition of Azomethine Ylides and Chromone-3-Carboxylic Acids Kowalska, Ewelina Sieroń, Lesław Albrecht, Anna Molecules Communication Herein, we describe the synthesis of a variety of chiral hybrid pyrrolidine-chromanone polycyclic derivatives. A convenient (3+2)-annulation of azomethine ylides with chromone-3-carboxylic acid realized under Brønsted base catalysis produced highly functionalized products in high yields with good stereoselectivities through asymmetric, intermolecular, and decarboxylative (3+2)-cyclization. MDPI 2022-10-11 /pmc/articles/PMC9607314/ /pubmed/36296402 http://dx.doi.org/10.3390/molecules27206809 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Kowalska, Ewelina
Sieroń, Lesław
Albrecht, Anna
Enantioselective, Decarboxylative (3+2)-Cycloaddition of Azomethine Ylides and Chromone-3-Carboxylic Acids
title Enantioselective, Decarboxylative (3+2)-Cycloaddition of Azomethine Ylides and Chromone-3-Carboxylic Acids
title_full Enantioselective, Decarboxylative (3+2)-Cycloaddition of Azomethine Ylides and Chromone-3-Carboxylic Acids
title_fullStr Enantioselective, Decarboxylative (3+2)-Cycloaddition of Azomethine Ylides and Chromone-3-Carboxylic Acids
title_full_unstemmed Enantioselective, Decarboxylative (3+2)-Cycloaddition of Azomethine Ylides and Chromone-3-Carboxylic Acids
title_short Enantioselective, Decarboxylative (3+2)-Cycloaddition of Azomethine Ylides and Chromone-3-Carboxylic Acids
title_sort enantioselective, decarboxylative (3+2)-cycloaddition of azomethine ylides and chromone-3-carboxylic acids
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607314/
https://www.ncbi.nlm.nih.gov/pubmed/36296402
http://dx.doi.org/10.3390/molecules27206809
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AT sieronlesław enantioselectivedecarboxylative32cycloadditionofazomethineylidesandchromone3carboxylicacids
AT albrechtanna enantioselectivedecarboxylative32cycloadditionofazomethineylidesandchromone3carboxylicacids

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