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Acquired Vitamin B12 Deficiency in Newborns: Positive Impact on Newborn Health through Early Detection
The early diagnosis of and intervention in vitamin B12 deficiency in exclusively breastfed infants by mothers with low vitamin B12 is crucial in preventing possible irreversible neurologic damage, megaloblastic anemia, and failure to thrive. We assess the usefulness of the early detection of asympto...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607322/ https://www.ncbi.nlm.nih.gov/pubmed/36297083 http://dx.doi.org/10.3390/nu14204397 |
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author | Lipari Pinto, Patrícia Florindo, Cristina Janeiro, Patrícia Santos, Rita Loureiro Mexia, Sandra Rocha, Hugo Tavares de Almeida, Isabel Vilarinho, Laura Gaspar, Ana |
author_facet | Lipari Pinto, Patrícia Florindo, Cristina Janeiro, Patrícia Santos, Rita Loureiro Mexia, Sandra Rocha, Hugo Tavares de Almeida, Isabel Vilarinho, Laura Gaspar, Ana |
author_sort | Lipari Pinto, Patrícia |
collection | PubMed |
description | The early diagnosis of and intervention in vitamin B12 deficiency in exclusively breastfed infants by mothers with low vitamin B12 is crucial in preventing possible irreversible neurologic damage, megaloblastic anemia, and failure to thrive. We assess the usefulness of the early detection of asymptomatic B12 deficiency related to acquired conditions and highlight the importance of monitoring serum vitamin B12 levels during pregnancy. We describe demographic, clinical, dietary, and biochemical data, including the evolution of a vitamin B12 deficiency’s functional biomarkers. We enrolled 12 newborns (5 males) with an age range of 1–2 months old that were exclusively breastfed and asymptomatic. These cases were referred to our metabolic unit due to alterations in expanded newborn screening: high levels of methylmalonic acid and/or total homocysteine (tHcy). All mothers were under a vegetarian diet except three who had abnormal B12 absorption, and all presented low or borderline serum B12 level and high plasma levels of tHcy. Supplementation with oral vitB12 re-established the metabolic homeostasis of the mothers. In infants, therapy with an intramuscular injection of 1.0 mg hydroxocobalamin led to the rapid normalization of the metabolic pattern, and a healthy outcome was observed. Acquired B12 deficiency should be ruled out before proceeding in a differential diagnosis of cobalamin metabolism deficits, methylmalonic acidemia, and homocystinuria. |
format | Online Article Text |
id | pubmed-9607322 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96073222022-10-28 Acquired Vitamin B12 Deficiency in Newborns: Positive Impact on Newborn Health through Early Detection Lipari Pinto, Patrícia Florindo, Cristina Janeiro, Patrícia Santos, Rita Loureiro Mexia, Sandra Rocha, Hugo Tavares de Almeida, Isabel Vilarinho, Laura Gaspar, Ana Nutrients Article The early diagnosis of and intervention in vitamin B12 deficiency in exclusively breastfed infants by mothers with low vitamin B12 is crucial in preventing possible irreversible neurologic damage, megaloblastic anemia, and failure to thrive. We assess the usefulness of the early detection of asymptomatic B12 deficiency related to acquired conditions and highlight the importance of monitoring serum vitamin B12 levels during pregnancy. We describe demographic, clinical, dietary, and biochemical data, including the evolution of a vitamin B12 deficiency’s functional biomarkers. We enrolled 12 newborns (5 males) with an age range of 1–2 months old that were exclusively breastfed and asymptomatic. These cases were referred to our metabolic unit due to alterations in expanded newborn screening: high levels of methylmalonic acid and/or total homocysteine (tHcy). All mothers were under a vegetarian diet except three who had abnormal B12 absorption, and all presented low or borderline serum B12 level and high plasma levels of tHcy. Supplementation with oral vitB12 re-established the metabolic homeostasis of the mothers. In infants, therapy with an intramuscular injection of 1.0 mg hydroxocobalamin led to the rapid normalization of the metabolic pattern, and a healthy outcome was observed. Acquired B12 deficiency should be ruled out before proceeding in a differential diagnosis of cobalamin metabolism deficits, methylmalonic acidemia, and homocystinuria. MDPI 2022-10-20 /pmc/articles/PMC9607322/ /pubmed/36297083 http://dx.doi.org/10.3390/nu14204397 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lipari Pinto, Patrícia Florindo, Cristina Janeiro, Patrícia Santos, Rita Loureiro Mexia, Sandra Rocha, Hugo Tavares de Almeida, Isabel Vilarinho, Laura Gaspar, Ana Acquired Vitamin B12 Deficiency in Newborns: Positive Impact on Newborn Health through Early Detection |
title | Acquired Vitamin B12 Deficiency in Newborns: Positive Impact on Newborn Health through Early Detection |
title_full | Acquired Vitamin B12 Deficiency in Newborns: Positive Impact on Newborn Health through Early Detection |
title_fullStr | Acquired Vitamin B12 Deficiency in Newborns: Positive Impact on Newborn Health through Early Detection |
title_full_unstemmed | Acquired Vitamin B12 Deficiency in Newborns: Positive Impact on Newborn Health through Early Detection |
title_short | Acquired Vitamin B12 Deficiency in Newborns: Positive Impact on Newborn Health through Early Detection |
title_sort | acquired vitamin b12 deficiency in newborns: positive impact on newborn health through early detection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607322/ https://www.ncbi.nlm.nih.gov/pubmed/36297083 http://dx.doi.org/10.3390/nu14204397 |
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