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Regulation of Extracellular Vesicle-Mediated Immune Responses against Antigen-Specific Presentation

Extracellular vesicles (EVs) produced by various immune cells, including B and T cells, macrophages, dendritic cells (DCs), natural killer (NK) cells, and mast cells, mediate intercellular communication and have attracted much attention owing to the novel delivery system of molecules in vivo. DCs ar...

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Detalles Bibliográficos
Autores principales: Matsuzaka, Yasunari, Yashiro, Ryu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607341/
https://www.ncbi.nlm.nih.gov/pubmed/36298556
http://dx.doi.org/10.3390/vaccines10101691
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author Matsuzaka, Yasunari
Yashiro, Ryu
author_facet Matsuzaka, Yasunari
Yashiro, Ryu
author_sort Matsuzaka, Yasunari
collection PubMed
description Extracellular vesicles (EVs) produced by various immune cells, including B and T cells, macrophages, dendritic cells (DCs), natural killer (NK) cells, and mast cells, mediate intercellular communication and have attracted much attention owing to the novel delivery system of molecules in vivo. DCs are among the most active exosome-secreting cells of the immune system. EVs produced by cancer cells contain cancer antigens; therefore, the development of vaccine therapy that does not require the identification of cancer antigens using cancer-cell-derived EVs may have significant clinical implications. In this review, we summarise the molecular mechanisms underlying EV-based immune responses and their therapeutic effects on tumour vaccination.
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spelling pubmed-96073412022-10-28 Regulation of Extracellular Vesicle-Mediated Immune Responses against Antigen-Specific Presentation Matsuzaka, Yasunari Yashiro, Ryu Vaccines (Basel) Review Extracellular vesicles (EVs) produced by various immune cells, including B and T cells, macrophages, dendritic cells (DCs), natural killer (NK) cells, and mast cells, mediate intercellular communication and have attracted much attention owing to the novel delivery system of molecules in vivo. DCs are among the most active exosome-secreting cells of the immune system. EVs produced by cancer cells contain cancer antigens; therefore, the development of vaccine therapy that does not require the identification of cancer antigens using cancer-cell-derived EVs may have significant clinical implications. In this review, we summarise the molecular mechanisms underlying EV-based immune responses and their therapeutic effects on tumour vaccination. MDPI 2022-10-10 /pmc/articles/PMC9607341/ /pubmed/36298556 http://dx.doi.org/10.3390/vaccines10101691 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Matsuzaka, Yasunari
Yashiro, Ryu
Regulation of Extracellular Vesicle-Mediated Immune Responses against Antigen-Specific Presentation
title Regulation of Extracellular Vesicle-Mediated Immune Responses against Antigen-Specific Presentation
title_full Regulation of Extracellular Vesicle-Mediated Immune Responses against Antigen-Specific Presentation
title_fullStr Regulation of Extracellular Vesicle-Mediated Immune Responses against Antigen-Specific Presentation
title_full_unstemmed Regulation of Extracellular Vesicle-Mediated Immune Responses against Antigen-Specific Presentation
title_short Regulation of Extracellular Vesicle-Mediated Immune Responses against Antigen-Specific Presentation
title_sort regulation of extracellular vesicle-mediated immune responses against antigen-specific presentation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607341/
https://www.ncbi.nlm.nih.gov/pubmed/36298556
http://dx.doi.org/10.3390/vaccines10101691
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