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Regulation of Extracellular Vesicle-Mediated Immune Responses against Antigen-Specific Presentation
Extracellular vesicles (EVs) produced by various immune cells, including B and T cells, macrophages, dendritic cells (DCs), natural killer (NK) cells, and mast cells, mediate intercellular communication and have attracted much attention owing to the novel delivery system of molecules in vivo. DCs ar...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607341/ https://www.ncbi.nlm.nih.gov/pubmed/36298556 http://dx.doi.org/10.3390/vaccines10101691 |
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author | Matsuzaka, Yasunari Yashiro, Ryu |
author_facet | Matsuzaka, Yasunari Yashiro, Ryu |
author_sort | Matsuzaka, Yasunari |
collection | PubMed |
description | Extracellular vesicles (EVs) produced by various immune cells, including B and T cells, macrophages, dendritic cells (DCs), natural killer (NK) cells, and mast cells, mediate intercellular communication and have attracted much attention owing to the novel delivery system of molecules in vivo. DCs are among the most active exosome-secreting cells of the immune system. EVs produced by cancer cells contain cancer antigens; therefore, the development of vaccine therapy that does not require the identification of cancer antigens using cancer-cell-derived EVs may have significant clinical implications. In this review, we summarise the molecular mechanisms underlying EV-based immune responses and their therapeutic effects on tumour vaccination. |
format | Online Article Text |
id | pubmed-9607341 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96073412022-10-28 Regulation of Extracellular Vesicle-Mediated Immune Responses against Antigen-Specific Presentation Matsuzaka, Yasunari Yashiro, Ryu Vaccines (Basel) Review Extracellular vesicles (EVs) produced by various immune cells, including B and T cells, macrophages, dendritic cells (DCs), natural killer (NK) cells, and mast cells, mediate intercellular communication and have attracted much attention owing to the novel delivery system of molecules in vivo. DCs are among the most active exosome-secreting cells of the immune system. EVs produced by cancer cells contain cancer antigens; therefore, the development of vaccine therapy that does not require the identification of cancer antigens using cancer-cell-derived EVs may have significant clinical implications. In this review, we summarise the molecular mechanisms underlying EV-based immune responses and their therapeutic effects on tumour vaccination. MDPI 2022-10-10 /pmc/articles/PMC9607341/ /pubmed/36298556 http://dx.doi.org/10.3390/vaccines10101691 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Matsuzaka, Yasunari Yashiro, Ryu Regulation of Extracellular Vesicle-Mediated Immune Responses against Antigen-Specific Presentation |
title | Regulation of Extracellular Vesicle-Mediated Immune Responses against Antigen-Specific Presentation |
title_full | Regulation of Extracellular Vesicle-Mediated Immune Responses against Antigen-Specific Presentation |
title_fullStr | Regulation of Extracellular Vesicle-Mediated Immune Responses against Antigen-Specific Presentation |
title_full_unstemmed | Regulation of Extracellular Vesicle-Mediated Immune Responses against Antigen-Specific Presentation |
title_short | Regulation of Extracellular Vesicle-Mediated Immune Responses against Antigen-Specific Presentation |
title_sort | regulation of extracellular vesicle-mediated immune responses against antigen-specific presentation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607341/ https://www.ncbi.nlm.nih.gov/pubmed/36298556 http://dx.doi.org/10.3390/vaccines10101691 |
work_keys_str_mv | AT matsuzakayasunari regulationofextracellularvesiclemediatedimmuneresponsesagainstantigenspecificpresentation AT yashiroryu regulationofextracellularvesiclemediatedimmuneresponsesagainstantigenspecificpresentation |