Mechanical Activation by Ball Milling as a Strategy to Prepare Highly Soluble Pharmaceutical Formulations in the Form of Co-Amorphous, Co-Crystals, or Polymorphs

Almost half of orally administered active pharmaceutical ingredients (APIs) have low solubility, which affects their bioavailability. In the last two decades, several alternatives have been proposed to modify the crystalline structure of APIs to improve their solubility; these strategies consist of...

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Detalles Bibliográficos
Autores principales: Martínez, Luz María, Cruz-Angeles, Jorge, Vázquez-Dávila, Mónica, Martínez, Eduardo, Cabada, Paulina, Navarrete-Bernal, Columba, Cortez, Flor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607342/
https://www.ncbi.nlm.nih.gov/pubmed/36297439
http://dx.doi.org/10.3390/pharmaceutics14102003

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