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Unexpected Stability of a Prodrug to Enzymatic Hydrolysis within a Hydrated HPMC Matrix Tablet

The uptake of alkaline phosphate present in dissolution medium into a hydrating hydroxypropyl methylcellulose matrix tablet and that its activity was retained therein was demonstrated. This presents a risk to the stability of prodrugs that are substrates of this enzyme such as phosphonooxymethyl der...

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Detalles Bibliográficos
Autores principales:	Hanley, Sarah, Brown, Jonathan, Timmins, Peter, Davies, Catrin, Dennis, Andrew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607376/ https://www.ncbi.nlm.nih.gov/pubmed/36297657 http://dx.doi.org/10.3390/pharmaceutics14102222

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