Cargando…

Chemical Modification of Curcumin into Its Semi-Synthetic Analogs Bearing Pyrimidinone Moiety as Anticancer Agents

Natural products (NPs) continue to provide a structural template for the design of novel therapeutic agents and expedite the drug discovery process. The majority of FDA-approved pharmaceuticals used in medical practice can be traced back to natural sources, and NPs play a significant role in drug de...

Descripción completa

Detalles Bibliográficos
Autores principales:	Afzal, Obaid, Yusuf, Mohammad, Ahsan, Mohamed Jawed, Altamimi, Abdulmalik S. A., Bakht, Md. Afroz, Ali, Amena, Salahuddin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607420/ https://www.ncbi.nlm.nih.gov/pubmed/36297760 http://dx.doi.org/10.3390/plants11202737

Ejemplares similares

Synthesis and Anticancer Evaluation of 4-Chloro-2-((5-aryl-1,3,4-oxadiazol-2-yl)amino)phenol Analogues: An Insight into Experimental and Theoretical Studies
por: Afzal, Obaid, et al.
Publicado: (2023)

Pyrazoline Containing Compounds as Therapeutic Targets for Neurodegenerative Disorders
por: Ahsan, Mohamed Jawed, et al.
Publicado: (2022)

Molecular Engineering of Curcumin, an Active Constituent of Curcuma longa L. (Turmeric) of the Family Zingiberaceae with Improved Antiproliferative Activity
por: Ali, Amena, et al.
Publicado: (2021)

Design, Synthesis, In Vivo, and In Silico Evaluation of Benzothiazoles Bearing a 1,3,4-Oxadiazole Moiety as New Antiepileptic Agents
por: Chauhan, Bharti, et al.
Publicado: (2023)

Synthesis, Anticancer Activity, and In Silico Studies of 5-(3-Bromophenyl)-N-aryl-4H-1,2,4-triazol-3-amine Analogs
por: Ahsan, Mohamed Jawed, et al.
Publicado: (2023)

Ultrasound promoted green synthesis, anticancer evaluation, and molecular docking studies of hydrazines: a pilot trial
por: Ali, Amena, et al.
Publicado: (2021)

Synthesis, DFT Analyses, Antiproliferative Activity, and Molecular Docking Studies of Curcumin Analogues
por: Ahsan, Mohamed Jawed, et al.
Publicado: (2022)

Design, Synthesis, ADME, and Anticancer Studies of Newer N-Aryl-5-(3,4,5-Trifluorophenyl)-1,3,4-Oxadiazol-2-Amines: An Insight into Experimental and Theoretical Investigations
por: Agarwal, Mohit, et al.
Publicado: (2023)

Induced Resistance Mechanism of Novel Curcumin Analogs Bearing a Quinazoline Moiety to Plant Virus
por: Yin, Limin, et al.
Publicado: (2018)

Synthesis of Novel 3H-Quinazolin-4-ones Containing Pyrazolinone, Pyrazole and Pyrimidinone Moieties
por: Saleh, Mohamed A., et al.
Publicado: (2003)

Synthesis, Characterisation, and In Vitro Anticancer Activity of Curcumin Analogues Bearing Pyrazole/Pyrimidine Ring Targeting EGFR Tyrosine Kinase
por: Ahsan, Mohamed Jawed, et al.
Publicado: (2013)

Synthesis and Insecticidal Activity of Mesoionic Pyrido[1,2-α]pyrimidinone Derivatives Containing a Neonicotinoid Moiety
por: Pan, Jianke, et al.
Publicado: (2018)

Analgesic and Anticancer Activity of Benzoxazole Clubbed 2-Pyrrolidinones as Novel Inhibitors of Monoacylglycerol Lipase
por: Afzal, Obaid, et al.
Publicado: (2021)

Synthesis and Anticancer Evaluation of New Thiazole and Thiadiazole Derivatives Bearing Acetanilide Moiety
por: El-Rayyes, Ali, et al.
Publicado: (2022)

Preferential Solvation Study of the Synthesized Aldose Reductase Inhibitor (SE415) in the {PEG 400 (1) + Water (2)} Cosolvent Mixture and GastroPlus-Based Prediction
por: Hussain, Afzal, et al.
Publicado: (2022)

Mechanistic of Vesicular Ethosomes and Elastic Liposomes on Permeation Profiles of Acyclovir across Artificial Membrane, Human Cultured EpiDerm, and Rat Skin: In Vitro-Ex Vivo Study
por: Hussain, Afzal, et al.
Publicado: (2023)

Synthesis and Bioactivity Evaluation of N-Arylsulfonylindole Analogs Bearing a Rhodanine Moiety as Antibacterial Agents
por: Song, Ming-Xia, et al.
Publicado: (2017)

Stereoselective Synthesis of the Di-Spirooxindole Analogs Based Oxindole and Cyclohexanone Moieties as Potential Anticancer Agents
por: Al-Majid, Abdullah Mohammed, et al.
Publicado: (2021)

Thymoquinone Induced Leishmanicidal Effect via Programmed Cell Death in Leishmania donovani
por: Islamuddin, Mohammad, et al.
Publicado: (2022)

Ameliorative Effect of Ethanolic Extract of Moringa oleifera Leaves in Combination with Curcumin against PTZ-Induced Kindled Epilepsy in Rats: In Vivo and In Silico
por: Alam, Md. Niyaz, et al.
Publicado: (2023)

Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides
por: Guo, Yaojie, et al.
Publicado: (2020)

Impact of Composition and Morphology of Ketoconazole-Loaded Solid Lipid Nanoparticles on Intestinal Permeation and Gastroplus-Based Prediction Studies
por: Aljurbui, Shaya Jubran, et al.
Publicado: (2022)

Anti-Arthritic and Anti-Inflammatory Potential of Spondias mangifera Extract Fractions: An In Silico, In Vitro and In Vivo Approach
por: Khalid, Mohammad, et al.
Publicado: (2021)

Site-specific antitumour effects of 2 pyrimidinone compounds in rats.
por: Eggermont, A. M., et al.
Publicado: (1986)

Novel Trifluoromethyl Pyrimidinone Compounds With Activity Against Mycobacterium tuberculosis
por: Hembre, Erik, et al.
Publicado: (2021)

Synthesis, Anticancer and Antitubercular Properties of New Chalcones and Their Nitrogen-Containing Five-Membered Heterocyclic Hybrids Bearing Sulfonamide Moiety
por: Castaño, Lina Fernanda, et al.
Publicado: (2022)

Ultrasound-assisted extraction of some branded tea: Optimization based on polyphenol content, antioxidant potential and thermodynamic study
por: Afroz Bakht, Md., et al.
Publicado: (2019)

Improved Subcutaneous Delivery of Ketoconazole Using EpiDerm and HSPiP Software-Based Simulations as Assessed by Cell Viability, Cellular Uptake, Permeation, and Hemolysis In Vitro Studies
por: Hussain, Afzal, et al.
Publicado: (2022)

Safe and targeted anticancer therapy for ovarian cancer using a novel class of curcumin analogs
por: Rath, Kellie S, et al.
Publicado: (2013)

Preparation, Characterization, and Evaluation of Curcumin–Graphene Oxide Complex-Loaded Liposomes against Staphylococcus aureus in Topical Disease
por: Rahman, Mahfoozur, et al.
Publicado: (2022)

Iron Oxide Nanoparticles with Supramolecular Ureido-Pyrimidinone Coating for Antimicrobial Peptide Delivery
por: Turrina, Chiara, et al.
Publicado: (2023)

Synthesis and characterization of novel bioactive 1,2,4-oxadiazole natural product analogs bearing the N-phenylmaleimide and N-phenylsuccinimide moieties
por: Maftei, Catalin V, et al.
Publicado: (2013)

Antidepressant potential of nitrogen-containing heterocyclic moieties: An updated review
por: Siddiqui, Nadeem, et al.
Publicado: (2011)

Design, synthesis and evaluation of anticancer activity of novel 2-thioxoimidazolidin-4-one derivatives bearing pyrazole, triazole and benzoxazole moieties
por: Elhady, Heba A., et al.
Publicado: (2018)

Design, Synthesis, In Vitro, and In Silico Studies of New N(5)-Substituted-pyrazolo[3,4-d]pyrimidinone Derivatives as Anticancer CDK2 Inhibitors
por: Zaki, Waheed A., et al.
Publicado: (2023)

Computational Approaches for the Design of Novel Anticancer Compounds Based on Pyrazolo[3,4-d]pyrimidine Derivatives as TRAP1 Inhibitor
por: Ali, Amena, et al.
Publicado: (2021)

Preferential Solvation Study of Rosuvastatin in the {PEG400 (1) + Water (2)} Cosolvent Mixture and GastroPlus Software-Based In Vivo Predictions
por: Hussain, Afzal, et al.
Publicado: (2023)

Amelioration of Cancer Employing Chitosan, Its Derivatives, and Chitosan-Based Nanoparticles: Recent Updates
por: Virmani, Tarun, et al.
Publicado: (2023)

Synthesis, Characterization, and In Vitro Antimicrobial and Anticancer Evaluation of Copolyester Bearing 4-Arylidene Curcumin in the Main Chain
por: Kandaswamy, Narendran, et al.
Publicado: (2014)

Continuous-flow retro-Diels–Alder reaction: an efficient method for the preparation of pyrimidinone derivatives
por: Nekkaa, Imane, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_lng8qg8j50e5qonv92d1m17tmr