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2D NMR Analysis as a Sensitive Tool for Evaluating the Higher-Order Structural Integrity of Monoclonal Antibody against COVID-19

The higher-order structure (HOS) of protein therapeutics has been confirmed as a critical quality parameter. In this study, we compared 2D (1)H-(13)C ALSOFAST-HMQC NMR spectra with immunochemical ELISA-based analysis to evaluate their sensitivity in assessing the HOS of a potent human monoclonal ant...

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Detalles Bibliográficos
Autores principales:	Cantini, Francesca, Andreano, Emanuele, Paciello, Ida, Ghini, Veronica, Berti, Francesco, Rappuoli, Rino, Banci, Lucia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607506/ https://www.ncbi.nlm.nih.gov/pubmed/36297417 http://dx.doi.org/10.3390/pharmaceutics14101981

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