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Schistosomiasis Mansoni-Recruited Eosinophils: An Overview in the Granuloma Context
Eosinophils are remarkably recruited during schistosomiasis mansoni, one of the most common parasitic diseases worldwide. These cells actively migrate and accumulate at sites of granulomatous inflammation termed granulomas, the main pathological feature of this disease. Eosinophils colonize granulom...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607553/ https://www.ncbi.nlm.nih.gov/pubmed/36296298 http://dx.doi.org/10.3390/microorganisms10102022 |
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author | Malta, Kássia K. Palazzi, Cinthia Neves, Vitor H. Aguiar, Yasmin Silva, Thiago P. Melo, Rossana C. N. |
author_facet | Malta, Kássia K. Palazzi, Cinthia Neves, Vitor H. Aguiar, Yasmin Silva, Thiago P. Melo, Rossana C. N. |
author_sort | Malta, Kássia K. |
collection | PubMed |
description | Eosinophils are remarkably recruited during schistosomiasis mansoni, one of the most common parasitic diseases worldwide. These cells actively migrate and accumulate at sites of granulomatous inflammation termed granulomas, the main pathological feature of this disease. Eosinophils colonize granulomas as a robust cell population and establish complex interactions with other immune cells and with the granuloma microenvironment. Eosinophils are the most abundant cells in granulomas induced by Schistosoma mansoni infection, but their functions during this disease remain unclear and even controversial. Here, we explore the current information on eosinophils as components of Schistosoma mansoni granulomas in both humans and natural and experimental models and their potential significance as central cells triggered by this infection. |
format | Online Article Text |
id | pubmed-9607553 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96075532022-10-28 Schistosomiasis Mansoni-Recruited Eosinophils: An Overview in the Granuloma Context Malta, Kássia K. Palazzi, Cinthia Neves, Vitor H. Aguiar, Yasmin Silva, Thiago P. Melo, Rossana C. N. Microorganisms Review Eosinophils are remarkably recruited during schistosomiasis mansoni, one of the most common parasitic diseases worldwide. These cells actively migrate and accumulate at sites of granulomatous inflammation termed granulomas, the main pathological feature of this disease. Eosinophils colonize granulomas as a robust cell population and establish complex interactions with other immune cells and with the granuloma microenvironment. Eosinophils are the most abundant cells in granulomas induced by Schistosoma mansoni infection, but their functions during this disease remain unclear and even controversial. Here, we explore the current information on eosinophils as components of Schistosoma mansoni granulomas in both humans and natural and experimental models and their potential significance as central cells triggered by this infection. MDPI 2022-10-13 /pmc/articles/PMC9607553/ /pubmed/36296298 http://dx.doi.org/10.3390/microorganisms10102022 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Malta, Kássia K. Palazzi, Cinthia Neves, Vitor H. Aguiar, Yasmin Silva, Thiago P. Melo, Rossana C. N. Schistosomiasis Mansoni-Recruited Eosinophils: An Overview in the Granuloma Context |
title | Schistosomiasis Mansoni-Recruited Eosinophils: An Overview in the Granuloma Context |
title_full | Schistosomiasis Mansoni-Recruited Eosinophils: An Overview in the Granuloma Context |
title_fullStr | Schistosomiasis Mansoni-Recruited Eosinophils: An Overview in the Granuloma Context |
title_full_unstemmed | Schistosomiasis Mansoni-Recruited Eosinophils: An Overview in the Granuloma Context |
title_short | Schistosomiasis Mansoni-Recruited Eosinophils: An Overview in the Granuloma Context |
title_sort | schistosomiasis mansoni-recruited eosinophils: an overview in the granuloma context |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607553/ https://www.ncbi.nlm.nih.gov/pubmed/36296298 http://dx.doi.org/10.3390/microorganisms10102022 |
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