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Schistosomiasis Mansoni-Recruited Eosinophils: An Overview in the Granuloma Context

Eosinophils are remarkably recruited during schistosomiasis mansoni, one of the most common parasitic diseases worldwide. These cells actively migrate and accumulate at sites of granulomatous inflammation termed granulomas, the main pathological feature of this disease. Eosinophils colonize granulom...

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Detalles Bibliográficos
Autores principales: Malta, Kássia K., Palazzi, Cinthia, Neves, Vitor H., Aguiar, Yasmin, Silva, Thiago P., Melo, Rossana C. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607553/
https://www.ncbi.nlm.nih.gov/pubmed/36296298
http://dx.doi.org/10.3390/microorganisms10102022
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author Malta, Kássia K.
Palazzi, Cinthia
Neves, Vitor H.
Aguiar, Yasmin
Silva, Thiago P.
Melo, Rossana C. N.
author_facet Malta, Kássia K.
Palazzi, Cinthia
Neves, Vitor H.
Aguiar, Yasmin
Silva, Thiago P.
Melo, Rossana C. N.
author_sort Malta, Kássia K.
collection PubMed
description Eosinophils are remarkably recruited during schistosomiasis mansoni, one of the most common parasitic diseases worldwide. These cells actively migrate and accumulate at sites of granulomatous inflammation termed granulomas, the main pathological feature of this disease. Eosinophils colonize granulomas as a robust cell population and establish complex interactions with other immune cells and with the granuloma microenvironment. Eosinophils are the most abundant cells in granulomas induced by Schistosoma mansoni infection, but their functions during this disease remain unclear and even controversial. Here, we explore the current information on eosinophils as components of Schistosoma mansoni granulomas in both humans and natural and experimental models and their potential significance as central cells triggered by this infection.
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spelling pubmed-96075532022-10-28 Schistosomiasis Mansoni-Recruited Eosinophils: An Overview in the Granuloma Context Malta, Kássia K. Palazzi, Cinthia Neves, Vitor H. Aguiar, Yasmin Silva, Thiago P. Melo, Rossana C. N. Microorganisms Review Eosinophils are remarkably recruited during schistosomiasis mansoni, one of the most common parasitic diseases worldwide. These cells actively migrate and accumulate at sites of granulomatous inflammation termed granulomas, the main pathological feature of this disease. Eosinophils colonize granulomas as a robust cell population and establish complex interactions with other immune cells and with the granuloma microenvironment. Eosinophils are the most abundant cells in granulomas induced by Schistosoma mansoni infection, but their functions during this disease remain unclear and even controversial. Here, we explore the current information on eosinophils as components of Schistosoma mansoni granulomas in both humans and natural and experimental models and their potential significance as central cells triggered by this infection. MDPI 2022-10-13 /pmc/articles/PMC9607553/ /pubmed/36296298 http://dx.doi.org/10.3390/microorganisms10102022 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Malta, Kássia K.
Palazzi, Cinthia
Neves, Vitor H.
Aguiar, Yasmin
Silva, Thiago P.
Melo, Rossana C. N.
Schistosomiasis Mansoni-Recruited Eosinophils: An Overview in the Granuloma Context
title Schistosomiasis Mansoni-Recruited Eosinophils: An Overview in the Granuloma Context
title_full Schistosomiasis Mansoni-Recruited Eosinophils: An Overview in the Granuloma Context
title_fullStr Schistosomiasis Mansoni-Recruited Eosinophils: An Overview in the Granuloma Context
title_full_unstemmed Schistosomiasis Mansoni-Recruited Eosinophils: An Overview in the Granuloma Context
title_short Schistosomiasis Mansoni-Recruited Eosinophils: An Overview in the Granuloma Context
title_sort schistosomiasis mansoni-recruited eosinophils: an overview in the granuloma context
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607553/
https://www.ncbi.nlm.nih.gov/pubmed/36296298
http://dx.doi.org/10.3390/microorganisms10102022
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