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The Role of Diacylglycerol Kinase in the Amelioration of Diabetic Nephropathy
The drastic increase in the number of patients with diabetes and its complications is a global issue. Diabetic nephropathy, the leading cause of chronic kidney disease, significantly affects patients’ quality of life and medical expenses. Furthermore, there are limited drugs for treating diabetic ne...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607625/ https://www.ncbi.nlm.nih.gov/pubmed/36296376 http://dx.doi.org/10.3390/molecules27206784 |
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author | Hayashi, Daiki Shirai, Yasuhito |
author_facet | Hayashi, Daiki Shirai, Yasuhito |
author_sort | Hayashi, Daiki |
collection | PubMed |
description | The drastic increase in the number of patients with diabetes and its complications is a global issue. Diabetic nephropathy, the leading cause of chronic kidney disease, significantly affects patients’ quality of life and medical expenses. Furthermore, there are limited drugs for treating diabetic nephropathy patients. Impaired lipid signaling, especially abnormal protein kinase C (PKC) activation by de novo-synthesized diacylglycerol (DG) under high blood glucose, is one of the causes of diabetic nephropathy. DG kinase (DGK) is an enzyme that phosphorylates DG and generates phosphatidic acid, i.e., DGK can inhibit PKC activation under diabetic conditions. Indeed, it has been proven that DGK activation ameliorates diabetic nephropathy. In this review, we summarize the involvement of PKC and DGK in diabetic nephropathy as therapeutic targets, and its mechanisms, by referring to our recent study. |
format | Online Article Text |
id | pubmed-9607625 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96076252022-10-28 The Role of Diacylglycerol Kinase in the Amelioration of Diabetic Nephropathy Hayashi, Daiki Shirai, Yasuhito Molecules Review The drastic increase in the number of patients with diabetes and its complications is a global issue. Diabetic nephropathy, the leading cause of chronic kidney disease, significantly affects patients’ quality of life and medical expenses. Furthermore, there are limited drugs for treating diabetic nephropathy patients. Impaired lipid signaling, especially abnormal protein kinase C (PKC) activation by de novo-synthesized diacylglycerol (DG) under high blood glucose, is one of the causes of diabetic nephropathy. DG kinase (DGK) is an enzyme that phosphorylates DG and generates phosphatidic acid, i.e., DGK can inhibit PKC activation under diabetic conditions. Indeed, it has been proven that DGK activation ameliorates diabetic nephropathy. In this review, we summarize the involvement of PKC and DGK in diabetic nephropathy as therapeutic targets, and its mechanisms, by referring to our recent study. MDPI 2022-10-11 /pmc/articles/PMC9607625/ /pubmed/36296376 http://dx.doi.org/10.3390/molecules27206784 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hayashi, Daiki Shirai, Yasuhito The Role of Diacylglycerol Kinase in the Amelioration of Diabetic Nephropathy |
title | The Role of Diacylglycerol Kinase in the Amelioration of Diabetic Nephropathy |
title_full | The Role of Diacylglycerol Kinase in the Amelioration of Diabetic Nephropathy |
title_fullStr | The Role of Diacylglycerol Kinase in the Amelioration of Diabetic Nephropathy |
title_full_unstemmed | The Role of Diacylglycerol Kinase in the Amelioration of Diabetic Nephropathy |
title_short | The Role of Diacylglycerol Kinase in the Amelioration of Diabetic Nephropathy |
title_sort | role of diacylglycerol kinase in the amelioration of diabetic nephropathy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607625/ https://www.ncbi.nlm.nih.gov/pubmed/36296376 http://dx.doi.org/10.3390/molecules27206784 |
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