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The Role of Diacylglycerol Kinase in the Amelioration of Diabetic Nephropathy

The drastic increase in the number of patients with diabetes and its complications is a global issue. Diabetic nephropathy, the leading cause of chronic kidney disease, significantly affects patients’ quality of life and medical expenses. Furthermore, there are limited drugs for treating diabetic ne...

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Autores principales: Hayashi, Daiki, Shirai, Yasuhito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607625/
https://www.ncbi.nlm.nih.gov/pubmed/36296376
http://dx.doi.org/10.3390/molecules27206784
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author Hayashi, Daiki
Shirai, Yasuhito
author_facet Hayashi, Daiki
Shirai, Yasuhito
author_sort Hayashi, Daiki
collection PubMed
description The drastic increase in the number of patients with diabetes and its complications is a global issue. Diabetic nephropathy, the leading cause of chronic kidney disease, significantly affects patients’ quality of life and medical expenses. Furthermore, there are limited drugs for treating diabetic nephropathy patients. Impaired lipid signaling, especially abnormal protein kinase C (PKC) activation by de novo-synthesized diacylglycerol (DG) under high blood glucose, is one of the causes of diabetic nephropathy. DG kinase (DGK) is an enzyme that phosphorylates DG and generates phosphatidic acid, i.e., DGK can inhibit PKC activation under diabetic conditions. Indeed, it has been proven that DGK activation ameliorates diabetic nephropathy. In this review, we summarize the involvement of PKC and DGK in diabetic nephropathy as therapeutic targets, and its mechanisms, by referring to our recent study.
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spelling pubmed-96076252022-10-28 The Role of Diacylglycerol Kinase in the Amelioration of Diabetic Nephropathy Hayashi, Daiki Shirai, Yasuhito Molecules Review The drastic increase in the number of patients with diabetes and its complications is a global issue. Diabetic nephropathy, the leading cause of chronic kidney disease, significantly affects patients’ quality of life and medical expenses. Furthermore, there are limited drugs for treating diabetic nephropathy patients. Impaired lipid signaling, especially abnormal protein kinase C (PKC) activation by de novo-synthesized diacylglycerol (DG) under high blood glucose, is one of the causes of diabetic nephropathy. DG kinase (DGK) is an enzyme that phosphorylates DG and generates phosphatidic acid, i.e., DGK can inhibit PKC activation under diabetic conditions. Indeed, it has been proven that DGK activation ameliorates diabetic nephropathy. In this review, we summarize the involvement of PKC and DGK in diabetic nephropathy as therapeutic targets, and its mechanisms, by referring to our recent study. MDPI 2022-10-11 /pmc/articles/PMC9607625/ /pubmed/36296376 http://dx.doi.org/10.3390/molecules27206784 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hayashi, Daiki
Shirai, Yasuhito
The Role of Diacylglycerol Kinase in the Amelioration of Diabetic Nephropathy
title The Role of Diacylglycerol Kinase in the Amelioration of Diabetic Nephropathy
title_full The Role of Diacylglycerol Kinase in the Amelioration of Diabetic Nephropathy
title_fullStr The Role of Diacylglycerol Kinase in the Amelioration of Diabetic Nephropathy
title_full_unstemmed The Role of Diacylglycerol Kinase in the Amelioration of Diabetic Nephropathy
title_short The Role of Diacylglycerol Kinase in the Amelioration of Diabetic Nephropathy
title_sort role of diacylglycerol kinase in the amelioration of diabetic nephropathy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607625/
https://www.ncbi.nlm.nih.gov/pubmed/36296376
http://dx.doi.org/10.3390/molecules27206784
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