Cargando…

A Novel Quantitative Computer-Assisted Score Can Improve Repeatability in the Estimate of Vascular Calcifications at the Abdominal Aorta

In CKD and in the elderly, Vascular Calcifications (VC) are associated to cardiovascular events and bone fractures. VC scores at the abdominal aorta (AA) from lateral spine radiographs are widely applied (the 0–24 semiquantitative discrete visual score (SV) being the most used). We hypothesised that...

Descripción completa

Detalles Bibliográficos
Autores principales: Fusaro, Maria, Schileo, Enrico, Crimi, Gianluigi, Aghi, Andrea, Bazzocchi, Alberto, Barbanti Brodano, Giovanni, Girolami, Marco, Sella, Stefania, Politi, Cristina, Ferrari, Serge, Gasperini, Chiara, Tripepi, Giovanni, Taddei, Fulvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607651/
https://www.ncbi.nlm.nih.gov/pubmed/36296959
http://dx.doi.org/10.3390/nu14204276
_version_ 1784818599541604352
author Fusaro, Maria
Schileo, Enrico
Crimi, Gianluigi
Aghi, Andrea
Bazzocchi, Alberto
Barbanti Brodano, Giovanni
Girolami, Marco
Sella, Stefania
Politi, Cristina
Ferrari, Serge
Gasperini, Chiara
Tripepi, Giovanni
Taddei, Fulvia
author_facet Fusaro, Maria
Schileo, Enrico
Crimi, Gianluigi
Aghi, Andrea
Bazzocchi, Alberto
Barbanti Brodano, Giovanni
Girolami, Marco
Sella, Stefania
Politi, Cristina
Ferrari, Serge
Gasperini, Chiara
Tripepi, Giovanni
Taddei, Fulvia
author_sort Fusaro, Maria
collection PubMed
description In CKD and in the elderly, Vascular Calcifications (VC) are associated to cardiovascular events and bone fractures. VC scores at the abdominal aorta (AA) from lateral spine radiographs are widely applied (the 0–24 semiquantitative discrete visual score (SV) being the most used). We hypothesised that a novel continuum score based on quantitative computer-assisted tracking of calcifications (QC score) can improve the precision of the SV score. This study tested the repeatability and reproducibility of QC score and SV score. In forty-four patients with VC from an earlier study, five experts from four specialties evaluated the data twice using a dedicated software. Test–retest was performed on eight subjects. QC results were reported in a 0–24 scale to readily compare with SV. The QC score showed higher intra-operator repeatability: the 95% CI of Bland–Altman differences was almost halved in QC; intra-operator R(2) improved from 0.67 for SV to 0.79 for QC. Inter-observer repeatability was higher for QC score in the first (Intraclass Correlation Coefficient 0.78 vs. 0.64), but not in the second evaluation (0.84 vs. 0.82), indicating a possible heavier learning artefact for SV. The Minimum Detectable Difference (MDD) was smaller for QC (2.98 vs. 4 for SV, in the 0–24 range). Both scores were insensitive to test–retest procedure. Notably, QC and SV scores were discordant: SV showed generally higher values, and an increasing trend of differences with VC severity. In summary, the new QC score improved the precision of lateral spine radiograph scores in estimating VC. We reported for the first time an estimate of MDD in VC assessment that was 25% lower for the new QC score with respect to the usual SV score. An ongoing study will determine whether this lower MDD may reduce follow-up times to check for VC progression.
format Online
Article
Text
id pubmed-9607651
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96076512022-10-28 A Novel Quantitative Computer-Assisted Score Can Improve Repeatability in the Estimate of Vascular Calcifications at the Abdominal Aorta Fusaro, Maria Schileo, Enrico Crimi, Gianluigi Aghi, Andrea Bazzocchi, Alberto Barbanti Brodano, Giovanni Girolami, Marco Sella, Stefania Politi, Cristina Ferrari, Serge Gasperini, Chiara Tripepi, Giovanni Taddei, Fulvia Nutrients Article In CKD and in the elderly, Vascular Calcifications (VC) are associated to cardiovascular events and bone fractures. VC scores at the abdominal aorta (AA) from lateral spine radiographs are widely applied (the 0–24 semiquantitative discrete visual score (SV) being the most used). We hypothesised that a novel continuum score based on quantitative computer-assisted tracking of calcifications (QC score) can improve the precision of the SV score. This study tested the repeatability and reproducibility of QC score and SV score. In forty-four patients with VC from an earlier study, five experts from four specialties evaluated the data twice using a dedicated software. Test–retest was performed on eight subjects. QC results were reported in a 0–24 scale to readily compare with SV. The QC score showed higher intra-operator repeatability: the 95% CI of Bland–Altman differences was almost halved in QC; intra-operator R(2) improved from 0.67 for SV to 0.79 for QC. Inter-observer repeatability was higher for QC score in the first (Intraclass Correlation Coefficient 0.78 vs. 0.64), but not in the second evaluation (0.84 vs. 0.82), indicating a possible heavier learning artefact for SV. The Minimum Detectable Difference (MDD) was smaller for QC (2.98 vs. 4 for SV, in the 0–24 range). Both scores were insensitive to test–retest procedure. Notably, QC and SV scores were discordant: SV showed generally higher values, and an increasing trend of differences with VC severity. In summary, the new QC score improved the precision of lateral spine radiograph scores in estimating VC. We reported for the first time an estimate of MDD in VC assessment that was 25% lower for the new QC score with respect to the usual SV score. An ongoing study will determine whether this lower MDD may reduce follow-up times to check for VC progression. MDPI 2022-10-13 /pmc/articles/PMC9607651/ /pubmed/36296959 http://dx.doi.org/10.3390/nu14204276 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fusaro, Maria
Schileo, Enrico
Crimi, Gianluigi
Aghi, Andrea
Bazzocchi, Alberto
Barbanti Brodano, Giovanni
Girolami, Marco
Sella, Stefania
Politi, Cristina
Ferrari, Serge
Gasperini, Chiara
Tripepi, Giovanni
Taddei, Fulvia
A Novel Quantitative Computer-Assisted Score Can Improve Repeatability in the Estimate of Vascular Calcifications at the Abdominal Aorta
title A Novel Quantitative Computer-Assisted Score Can Improve Repeatability in the Estimate of Vascular Calcifications at the Abdominal Aorta
title_full A Novel Quantitative Computer-Assisted Score Can Improve Repeatability in the Estimate of Vascular Calcifications at the Abdominal Aorta
title_fullStr A Novel Quantitative Computer-Assisted Score Can Improve Repeatability in the Estimate of Vascular Calcifications at the Abdominal Aorta
title_full_unstemmed A Novel Quantitative Computer-Assisted Score Can Improve Repeatability in the Estimate of Vascular Calcifications at the Abdominal Aorta
title_short A Novel Quantitative Computer-Assisted Score Can Improve Repeatability in the Estimate of Vascular Calcifications at the Abdominal Aorta
title_sort novel quantitative computer-assisted score can improve repeatability in the estimate of vascular calcifications at the abdominal aorta
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607651/
https://www.ncbi.nlm.nih.gov/pubmed/36296959
http://dx.doi.org/10.3390/nu14204276
work_keys_str_mv AT fusaromaria anovelquantitativecomputerassistedscorecanimproverepeatabilityintheestimateofvascularcalcificationsattheabdominalaorta
AT schileoenrico anovelquantitativecomputerassistedscorecanimproverepeatabilityintheestimateofvascularcalcificationsattheabdominalaorta
AT crimigianluigi anovelquantitativecomputerassistedscorecanimproverepeatabilityintheestimateofvascularcalcificationsattheabdominalaorta
AT aghiandrea anovelquantitativecomputerassistedscorecanimproverepeatabilityintheestimateofvascularcalcificationsattheabdominalaorta
AT bazzocchialberto anovelquantitativecomputerassistedscorecanimproverepeatabilityintheestimateofvascularcalcificationsattheabdominalaorta
AT barbantibrodanogiovanni anovelquantitativecomputerassistedscorecanimproverepeatabilityintheestimateofvascularcalcificationsattheabdominalaorta
AT girolamimarco anovelquantitativecomputerassistedscorecanimproverepeatabilityintheestimateofvascularcalcificationsattheabdominalaorta
AT sellastefania anovelquantitativecomputerassistedscorecanimproverepeatabilityintheestimateofvascularcalcificationsattheabdominalaorta
AT politicristina anovelquantitativecomputerassistedscorecanimproverepeatabilityintheestimateofvascularcalcificationsattheabdominalaorta
AT ferrariserge anovelquantitativecomputerassistedscorecanimproverepeatabilityintheestimateofvascularcalcificationsattheabdominalaorta
AT gasperinichiara anovelquantitativecomputerassistedscorecanimproverepeatabilityintheestimateofvascularcalcificationsattheabdominalaorta
AT tripepigiovanni anovelquantitativecomputerassistedscorecanimproverepeatabilityintheestimateofvascularcalcificationsattheabdominalaorta
AT taddeifulvia anovelquantitativecomputerassistedscorecanimproverepeatabilityintheestimateofvascularcalcificationsattheabdominalaorta
AT fusaromaria novelquantitativecomputerassistedscorecanimproverepeatabilityintheestimateofvascularcalcificationsattheabdominalaorta
AT schileoenrico novelquantitativecomputerassistedscorecanimproverepeatabilityintheestimateofvascularcalcificationsattheabdominalaorta
AT crimigianluigi novelquantitativecomputerassistedscorecanimproverepeatabilityintheestimateofvascularcalcificationsattheabdominalaorta
AT aghiandrea novelquantitativecomputerassistedscorecanimproverepeatabilityintheestimateofvascularcalcificationsattheabdominalaorta
AT bazzocchialberto novelquantitativecomputerassistedscorecanimproverepeatabilityintheestimateofvascularcalcificationsattheabdominalaorta
AT barbantibrodanogiovanni novelquantitativecomputerassistedscorecanimproverepeatabilityintheestimateofvascularcalcificationsattheabdominalaorta
AT girolamimarco novelquantitativecomputerassistedscorecanimproverepeatabilityintheestimateofvascularcalcificationsattheabdominalaorta
AT sellastefania novelquantitativecomputerassistedscorecanimproverepeatabilityintheestimateofvascularcalcificationsattheabdominalaorta
AT politicristina novelquantitativecomputerassistedscorecanimproverepeatabilityintheestimateofvascularcalcificationsattheabdominalaorta
AT ferrariserge novelquantitativecomputerassistedscorecanimproverepeatabilityintheestimateofvascularcalcificationsattheabdominalaorta
AT gasperinichiara novelquantitativecomputerassistedscorecanimproverepeatabilityintheestimateofvascularcalcificationsattheabdominalaorta
AT tripepigiovanni novelquantitativecomputerassistedscorecanimproverepeatabilityintheestimateofvascularcalcificationsattheabdominalaorta
AT taddeifulvia novelquantitativecomputerassistedscorecanimproverepeatabilityintheestimateofvascularcalcificationsattheabdominalaorta