Solid–Liquid Equilibrium Behavior and Solvent Effect of Gliclazide in Mono- and Binary Solvents

[Image: see text] The solubility data of gliclazide in 10 mono-solvents (1,2-dichloroethane, 1,4-dioxane, 2-methoxyethanol, n-propyl acetate, isopropyl acetate, n-butyl acetate, pentyl acetate, dimethyl sulfoxide (DMSO), N,N-dimethylacetamide (DMA), and 2-butanone) and one kind of binary solvent (DM...

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Autores principales: Wang, Zihao, Yu, Shuai, Li, Hongcheng, Liu, Bin, Xia, Yan, Guo, Jianhui, Xue, Fumin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607677/
https://www.ncbi.nlm.nih.gov/pubmed/36312391
http://dx.doi.org/10.1021/acsomega.2c04540
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author Wang, Zihao
Yu, Shuai
Li, Hongcheng
Liu, Bin
Xia, Yan
Guo, Jianhui
Xue, Fumin
author_facet Wang, Zihao
Yu, Shuai
Li, Hongcheng
Liu, Bin
Xia, Yan
Guo, Jianhui
Xue, Fumin
author_sort Wang, Zihao
collection PubMed
description [Image: see text] The solubility data of gliclazide in 10 mono-solvents (1,2-dichloroethane, 1,4-dioxane, 2-methoxyethanol, n-propyl acetate, isopropyl acetate, n-butyl acetate, pentyl acetate, dimethyl sulfoxide (DMSO), N,N-dimethylacetamide (DMA), and 2-butanone) and one kind of binary solvent (DMA + water) were measured between 278.15 and 323.15 K under atmospheric pressure by the gravimetric method. The Hansen solubility parameters and the KAT-LSER equation were used to investigate the solubility order and the influence of solvent effects on solubility. The experimental data were correlated by six thermodynamic models (the λh model, the Yaws model, the Apelblat model, the Jouyban model, the modified Jouyban–Acree model, and the Sun model). The results show that all of these models can correlate the experimental data well. Among them, the Apelblat model is the most suitable for correlating the solubility data of gliclazide in mono-solvents and binary solvents.
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spelling pubmed-96076772022-10-28 Solid–Liquid Equilibrium Behavior and Solvent Effect of Gliclazide in Mono- and Binary Solvents Wang, Zihao Yu, Shuai Li, Hongcheng Liu, Bin Xia, Yan Guo, Jianhui Xue, Fumin ACS Omega [Image: see text] The solubility data of gliclazide in 10 mono-solvents (1,2-dichloroethane, 1,4-dioxane, 2-methoxyethanol, n-propyl acetate, isopropyl acetate, n-butyl acetate, pentyl acetate, dimethyl sulfoxide (DMSO), N,N-dimethylacetamide (DMA), and 2-butanone) and one kind of binary solvent (DMA + water) were measured between 278.15 and 323.15 K under atmospheric pressure by the gravimetric method. The Hansen solubility parameters and the KAT-LSER equation were used to investigate the solubility order and the influence of solvent effects on solubility. The experimental data were correlated by six thermodynamic models (the λh model, the Yaws model, the Apelblat model, the Jouyban model, the modified Jouyban–Acree model, and the Sun model). The results show that all of these models can correlate the experimental data well. Among them, the Apelblat model is the most suitable for correlating the solubility data of gliclazide in mono-solvents and binary solvents. American Chemical Society 2022-10-12 /pmc/articles/PMC9607677/ /pubmed/36312391 http://dx.doi.org/10.1021/acsomega.2c04540 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Wang, Zihao
Yu, Shuai
Li, Hongcheng
Liu, Bin
Xia, Yan
Guo, Jianhui
Xue, Fumin
Solid–Liquid Equilibrium Behavior and Solvent Effect of Gliclazide in Mono- and Binary Solvents
title Solid–Liquid Equilibrium Behavior and Solvent Effect of Gliclazide in Mono- and Binary Solvents
title_full Solid–Liquid Equilibrium Behavior and Solvent Effect of Gliclazide in Mono- and Binary Solvents
title_fullStr Solid–Liquid Equilibrium Behavior and Solvent Effect of Gliclazide in Mono- and Binary Solvents
title_full_unstemmed Solid–Liquid Equilibrium Behavior and Solvent Effect of Gliclazide in Mono- and Binary Solvents
title_short Solid–Liquid Equilibrium Behavior and Solvent Effect of Gliclazide in Mono- and Binary Solvents
title_sort solid–liquid equilibrium behavior and solvent effect of gliclazide in mono- and binary solvents
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607677/
https://www.ncbi.nlm.nih.gov/pubmed/36312391
http://dx.doi.org/10.1021/acsomega.2c04540
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