Overestimation of the effect of (fos)aprepitant on intravenous dexamethasone pharmacokinetics requires adaptation of the guidelines for children with chemotherapy-induced nausea and vomiting

PURPOSE: Chemotherapy-induced nausea and vomiting (CINV) are common side effects in pediatric oncology treatment. Besides 5-HT(3)-antagonists, both dexamethasone and aprepitant are cornerstone drugs in controlling these side effects. Based on results of adult studies, the dexamethasone dose is reduc...

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Detalles Bibliográficos
Autores principales: Nijstad, A. Laura, de Vos-Kerkhof, Evelien, Enters-Weijnen, Catherine F., van de Wetering, Marianne D., Tissing, Wim J. E., Tibben, Matthijs M., Rosing, Hilde, Lalmohamed, Arief, Huitema, Alwin D. R., Zwaan, C. Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607815/
https://www.ncbi.nlm.nih.gov/pubmed/36287279
http://dx.doi.org/10.1007/s00520-022-07423-6

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