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Evaluation of Newly Designed and Traditional Punches in Manufacturing of Scored ODTs
To overcome difficulties in splitting, uneven breaking and inconsistent dosing frequently reported with scored tablets, a novel punch was proposed for the manufacturing of easy breakable tablets (EBTs). In this work, the performance of the EBT punch was investigated vs. a ridged one for traditional...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607861/ https://www.ncbi.nlm.nih.gov/pubmed/36297490 http://dx.doi.org/10.3390/pharmaceutics14102054 |
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author | Palugan, Luca Moutaharrik, Saliha Maroni, Alessandra Foppoli, Anastasia Anna Melocchi, Alice Vecchio, Carlo Gazzaniga, Andrea Cerea, Matteo |
author_facet | Palugan, Luca Moutaharrik, Saliha Maroni, Alessandra Foppoli, Anastasia Anna Melocchi, Alice Vecchio, Carlo Gazzaniga, Andrea Cerea, Matteo |
author_sort | Palugan, Luca |
collection | PubMed |
description | To overcome difficulties in splitting, uneven breaking and inconsistent dosing frequently reported with scored tablets, a novel punch was proposed for the manufacturing of easy breakable tablets (EBTs). In this work, the performance of the EBT punch was investigated vs. a ridged one for traditional breakable tablets (TBTs) using a furosemide powder formulation for orally disintegrating tablets (ODTs). A Face Centered Central Composite Design was applied to investigate the influence of punch type, compaction force, tablet weight and press rotation speed on the mechanical properties of ODTs, their behavior in aqueous fluids and aptitude for splitting. Mass uniformity and adequate crushing strength, friability, water uptake, disintegration and wetting times were obtained from both TBTs and EBTs. Interestingly, more favorable splitting behavior was shown by tablets manufactured by the novel punch, in view of lower mass loss and portion mass variability after breaking. The ease of breaking, accuracy of subdivision and mass loss of ODTs were also evaluated by a volunteer (n = 20) panel test. Less difficulty was found in splitting EBTs than TBTs (p < 0.05), and a larger number of tablets were properly broken into four parts. Thus, this study proved the usefulness of the EBT punch in overcoming drawbacks associated with divisible tablets. |
format | Online Article Text |
id | pubmed-9607861 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96078612022-10-28 Evaluation of Newly Designed and Traditional Punches in Manufacturing of Scored ODTs Palugan, Luca Moutaharrik, Saliha Maroni, Alessandra Foppoli, Anastasia Anna Melocchi, Alice Vecchio, Carlo Gazzaniga, Andrea Cerea, Matteo Pharmaceutics Article To overcome difficulties in splitting, uneven breaking and inconsistent dosing frequently reported with scored tablets, a novel punch was proposed for the manufacturing of easy breakable tablets (EBTs). In this work, the performance of the EBT punch was investigated vs. a ridged one for traditional breakable tablets (TBTs) using a furosemide powder formulation for orally disintegrating tablets (ODTs). A Face Centered Central Composite Design was applied to investigate the influence of punch type, compaction force, tablet weight and press rotation speed on the mechanical properties of ODTs, their behavior in aqueous fluids and aptitude for splitting. Mass uniformity and adequate crushing strength, friability, water uptake, disintegration and wetting times were obtained from both TBTs and EBTs. Interestingly, more favorable splitting behavior was shown by tablets manufactured by the novel punch, in view of lower mass loss and portion mass variability after breaking. The ease of breaking, accuracy of subdivision and mass loss of ODTs were also evaluated by a volunteer (n = 20) panel test. Less difficulty was found in splitting EBTs than TBTs (p < 0.05), and a larger number of tablets were properly broken into four parts. Thus, this study proved the usefulness of the EBT punch in overcoming drawbacks associated with divisible tablets. MDPI 2022-09-27 /pmc/articles/PMC9607861/ /pubmed/36297490 http://dx.doi.org/10.3390/pharmaceutics14102054 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Palugan, Luca Moutaharrik, Saliha Maroni, Alessandra Foppoli, Anastasia Anna Melocchi, Alice Vecchio, Carlo Gazzaniga, Andrea Cerea, Matteo Evaluation of Newly Designed and Traditional Punches in Manufacturing of Scored ODTs |
title | Evaluation of Newly Designed and Traditional Punches in Manufacturing of Scored ODTs |
title_full | Evaluation of Newly Designed and Traditional Punches in Manufacturing of Scored ODTs |
title_fullStr | Evaluation of Newly Designed and Traditional Punches in Manufacturing of Scored ODTs |
title_full_unstemmed | Evaluation of Newly Designed and Traditional Punches in Manufacturing of Scored ODTs |
title_short | Evaluation of Newly Designed and Traditional Punches in Manufacturing of Scored ODTs |
title_sort | evaluation of newly designed and traditional punches in manufacturing of scored odts |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607861/ https://www.ncbi.nlm.nih.gov/pubmed/36297490 http://dx.doi.org/10.3390/pharmaceutics14102054 |
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