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Antimicrobial and Cytotoxic Effects of Cannabinoids: An Updated Review with Future Perspectives and Current Challenges

The development of new antibiotics is urgently needed to combat the threat of bacterial resistance. New classes of compounds that have novel properties are urgently needed for the development of effective antimicrobial agents. The extract of Cannabis sativa L. has been used to treat multiple ailment...

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Autores principales: Saleemi, Mansab Ali, Yahaya, Noorfatimah, Zain, Nur Nadhirah Mohamad, Raoov, Muggundha, Yong, Yoke Keong, Noor, Nurul Shahfiza, Lim, Vuanghao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607911/
https://www.ncbi.nlm.nih.gov/pubmed/36297340
http://dx.doi.org/10.3390/ph15101228
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author Saleemi, Mansab Ali
Yahaya, Noorfatimah
Zain, Nur Nadhirah Mohamad
Raoov, Muggundha
Yong, Yoke Keong
Noor, Nurul Shahfiza
Lim, Vuanghao
author_facet Saleemi, Mansab Ali
Yahaya, Noorfatimah
Zain, Nur Nadhirah Mohamad
Raoov, Muggundha
Yong, Yoke Keong
Noor, Nurul Shahfiza
Lim, Vuanghao
author_sort Saleemi, Mansab Ali
collection PubMed
description The development of new antibiotics is urgently needed to combat the threat of bacterial resistance. New classes of compounds that have novel properties are urgently needed for the development of effective antimicrobial agents. The extract of Cannabis sativa L. has been used to treat multiple ailments since ancient times. Its bioactivity is largely attributed to the cannabinoids found in its plant. Researchers are currently searching for new anti-infective agents that can treat various infections. Although its phytocannabinoid ingredients have a wide range of medical benefits beyond the treatment of infections, they are primarily associated to psychotropic effects. Different cannabinoids have been demonstrated to be helpful against harmful bacteria, including Gram-positive bacteria. Moreover, combination therapy involving the use of different antibiotics has shown synergism and broad-spectrum activity. The purpose of this review is to gather current data on the actions of Cannabis sativa (C. sativa) extracts and its primary constituents such as terpenes and cannabinoids towards pathogens in order to determine their antimicrobial properties and cytotoxic effects together with current challenges and future perspectives in biomedical application.
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spelling pubmed-96079112022-10-28 Antimicrobial and Cytotoxic Effects of Cannabinoids: An Updated Review with Future Perspectives and Current Challenges Saleemi, Mansab Ali Yahaya, Noorfatimah Zain, Nur Nadhirah Mohamad Raoov, Muggundha Yong, Yoke Keong Noor, Nurul Shahfiza Lim, Vuanghao Pharmaceuticals (Basel) Review The development of new antibiotics is urgently needed to combat the threat of bacterial resistance. New classes of compounds that have novel properties are urgently needed for the development of effective antimicrobial agents. The extract of Cannabis sativa L. has been used to treat multiple ailments since ancient times. Its bioactivity is largely attributed to the cannabinoids found in its plant. Researchers are currently searching for new anti-infective agents that can treat various infections. Although its phytocannabinoid ingredients have a wide range of medical benefits beyond the treatment of infections, they are primarily associated to psychotropic effects. Different cannabinoids have been demonstrated to be helpful against harmful bacteria, including Gram-positive bacteria. Moreover, combination therapy involving the use of different antibiotics has shown synergism and broad-spectrum activity. The purpose of this review is to gather current data on the actions of Cannabis sativa (C. sativa) extracts and its primary constituents such as terpenes and cannabinoids towards pathogens in order to determine their antimicrobial properties and cytotoxic effects together with current challenges and future perspectives in biomedical application. MDPI 2022-10-06 /pmc/articles/PMC9607911/ /pubmed/36297340 http://dx.doi.org/10.3390/ph15101228 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Saleemi, Mansab Ali
Yahaya, Noorfatimah
Zain, Nur Nadhirah Mohamad
Raoov, Muggundha
Yong, Yoke Keong
Noor, Nurul Shahfiza
Lim, Vuanghao
Antimicrobial and Cytotoxic Effects of Cannabinoids: An Updated Review with Future Perspectives and Current Challenges
title Antimicrobial and Cytotoxic Effects of Cannabinoids: An Updated Review with Future Perspectives and Current Challenges
title_full Antimicrobial and Cytotoxic Effects of Cannabinoids: An Updated Review with Future Perspectives and Current Challenges
title_fullStr Antimicrobial and Cytotoxic Effects of Cannabinoids: An Updated Review with Future Perspectives and Current Challenges
title_full_unstemmed Antimicrobial and Cytotoxic Effects of Cannabinoids: An Updated Review with Future Perspectives and Current Challenges
title_short Antimicrobial and Cytotoxic Effects of Cannabinoids: An Updated Review with Future Perspectives and Current Challenges
title_sort antimicrobial and cytotoxic effects of cannabinoids: an updated review with future perspectives and current challenges
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607911/
https://www.ncbi.nlm.nih.gov/pubmed/36297340
http://dx.doi.org/10.3390/ph15101228
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