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Retention Time Extended by Nanoparticles Improves the Eradication of Highly Antibiotic-Resistant Helicobacter pylori

Helicobacter pylori infection usually causes gastrointestinal complications, including gastrointestinal bleeding or perforation, and serious infections may lead to gastric cancer. Amoxicillin is used to treat numerous bacterial infections but is easily decomposed in the gastric acid environment via...

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Autores principales: Yao, Cheng-Jung, Yang, Shu-Jyuan, Huang, Chung-Huan, Chang, Yuan-Ting, Wang, Chung-Hao, Shieh, Ming-Jium, Young, Tai-Horng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608011/
https://www.ncbi.nlm.nih.gov/pubmed/36297552
http://dx.doi.org/10.3390/pharmaceutics14102117
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author Yao, Cheng-Jung
Yang, Shu-Jyuan
Huang, Chung-Huan
Chang, Yuan-Ting
Wang, Chung-Hao
Shieh, Ming-Jium
Young, Tai-Horng
author_facet Yao, Cheng-Jung
Yang, Shu-Jyuan
Huang, Chung-Huan
Chang, Yuan-Ting
Wang, Chung-Hao
Shieh, Ming-Jium
Young, Tai-Horng
author_sort Yao, Cheng-Jung
collection PubMed
description Helicobacter pylori infection usually causes gastrointestinal complications, including gastrointestinal bleeding or perforation, and serious infections may lead to gastric cancer. Amoxicillin is used to treat numerous bacterial infections but is easily decomposed in the gastric acid environment via the hydrolyzation of the β-lactam ring. In this study, we develop chitosan-based nanoparticles loaded with amoxicillin (CAANs) as an H. pylori eradication platform. The CAANs were biocompatible and could retain the antibiotic activity of amoxicillin against H. pylori growth. The mucoadhesive property of chitosan and alginate enabled the CAANs to adhere to the mucus layers and penetrate through these to release amoxicillin in the space between the layers and the gastric epithelium. The use of this nanoparticle could prolong the retention time and preserve the antibiotic activity of amoxicillin in the stomach and help enhance the eradication rate of H. pylori and reduce treatment time. These CAANs, therefore, show potential for the effective treatment of highly antibiotic-resistant H. pylori infection using amoxicillin.
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spelling pubmed-96080112022-10-28 Retention Time Extended by Nanoparticles Improves the Eradication of Highly Antibiotic-Resistant Helicobacter pylori Yao, Cheng-Jung Yang, Shu-Jyuan Huang, Chung-Huan Chang, Yuan-Ting Wang, Chung-Hao Shieh, Ming-Jium Young, Tai-Horng Pharmaceutics Article Helicobacter pylori infection usually causes gastrointestinal complications, including gastrointestinal bleeding or perforation, and serious infections may lead to gastric cancer. Amoxicillin is used to treat numerous bacterial infections but is easily decomposed in the gastric acid environment via the hydrolyzation of the β-lactam ring. In this study, we develop chitosan-based nanoparticles loaded with amoxicillin (CAANs) as an H. pylori eradication platform. The CAANs were biocompatible and could retain the antibiotic activity of amoxicillin against H. pylori growth. The mucoadhesive property of chitosan and alginate enabled the CAANs to adhere to the mucus layers and penetrate through these to release amoxicillin in the space between the layers and the gastric epithelium. The use of this nanoparticle could prolong the retention time and preserve the antibiotic activity of amoxicillin in the stomach and help enhance the eradication rate of H. pylori and reduce treatment time. These CAANs, therefore, show potential for the effective treatment of highly antibiotic-resistant H. pylori infection using amoxicillin. MDPI 2022-10-05 /pmc/articles/PMC9608011/ /pubmed/36297552 http://dx.doi.org/10.3390/pharmaceutics14102117 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yao, Cheng-Jung
Yang, Shu-Jyuan
Huang, Chung-Huan
Chang, Yuan-Ting
Wang, Chung-Hao
Shieh, Ming-Jium
Young, Tai-Horng
Retention Time Extended by Nanoparticles Improves the Eradication of Highly Antibiotic-Resistant Helicobacter pylori
title Retention Time Extended by Nanoparticles Improves the Eradication of Highly Antibiotic-Resistant Helicobacter pylori
title_full Retention Time Extended by Nanoparticles Improves the Eradication of Highly Antibiotic-Resistant Helicobacter pylori
title_fullStr Retention Time Extended by Nanoparticles Improves the Eradication of Highly Antibiotic-Resistant Helicobacter pylori
title_full_unstemmed Retention Time Extended by Nanoparticles Improves the Eradication of Highly Antibiotic-Resistant Helicobacter pylori
title_short Retention Time Extended by Nanoparticles Improves the Eradication of Highly Antibiotic-Resistant Helicobacter pylori
title_sort retention time extended by nanoparticles improves the eradication of highly antibiotic-resistant helicobacter pylori
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608011/
https://www.ncbi.nlm.nih.gov/pubmed/36297552
http://dx.doi.org/10.3390/pharmaceutics14102117
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