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In-hospital Mortality Rates in SARS-CoV-2 Patients Treated with Enoxaparin and Heparin

OBJECTIVES: This study aimed to investigate in-hospital mortality rates in patients with coronavirus disease (COVID-19) according to enoxaparin and heparin use. METHODS: This retrospective cohort study included 962 patients admitted to two hospitals in Kuwait with a confirmed diagnosis of COVID-19....

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Autores principales: Alroomi, Moudhi, Alsaber, Ahmad, Al-Bader, Bader, Almutairi, Farah, Malhas, Haya, Pan, Jiazhu, Zhanna, Kobalava D., Ramadhan, Maryam, Saleh, Mohammad Al, Abdullah, Mohammed, Alotaibi, Naser, AlNasrallah, Noor, Rajan, Rajesh, Hussein, Soumoud, Aboelhassan, Wael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608030/
https://www.ncbi.nlm.nih.gov/pubmed/36285386
http://dx.doi.org/10.1177/10760296221131802
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author Alroomi, Moudhi
Alsaber, Ahmad
Al-Bader, Bader
Almutairi, Farah
Malhas, Haya
Pan, Jiazhu
Zhanna, Kobalava D.
Ramadhan, Maryam
Saleh, Mohammad Al
Abdullah, Mohammed
Alotaibi, Naser
AlNasrallah, Noor
Rajan, Rajesh
Hussein, Soumoud
Aboelhassan, Wael
author_facet Alroomi, Moudhi
Alsaber, Ahmad
Al-Bader, Bader
Almutairi, Farah
Malhas, Haya
Pan, Jiazhu
Zhanna, Kobalava D.
Ramadhan, Maryam
Saleh, Mohammad Al
Abdullah, Mohammed
Alotaibi, Naser
AlNasrallah, Noor
Rajan, Rajesh
Hussein, Soumoud
Aboelhassan, Wael
author_sort Alroomi, Moudhi
collection PubMed
description OBJECTIVES: This study aimed to investigate in-hospital mortality rates in patients with coronavirus disease (COVID-19) according to enoxaparin and heparin use. METHODS: This retrospective cohort study included 962 patients admitted to two hospitals in Kuwait with a confirmed diagnosis of COVID-19. Cumulative all-cause mortality rate was the primary outcome. RESULTS: A total of 302 patients (males, 196 [64.9%]; mean age, 57.2 ± 14.6 years; mean body mass index, 29.8 ± 6.5 kg/m(2)) received anticoagulation therapy. Patients receiving anticoagulation treatment tended to have pneumonia (n = 275 [91.1%]) or acute respiratory distress syndrome (n = 106 [35.1%]), and high D-dimer levels (median [interquartile range]: 608 [523;707] ng/mL). The mortality rate in this group was high (n = 63 [20.9%]). Multivariable logistic regression, the Cox proportional hazards, and Kaplan-Meier models revealed that the use of therapeutic anticoagulation agents affected the risk of all-cause cumulative mortality. CONCLUSION: Age, hypertension, pneumonia, therapeutic anticoagulation, and methylprednisolone use were found to be strong predictors of in-hospital mortality. In elderly hypertensive COVID-19 patients on therapeutic anticoagulation were found to have 2.3 times higher risk of in-hospital mortality. All cause in-hospital mortality rate in the therapeutic anticoagulation group was up to 21%.
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spelling pubmed-96080302022-10-28 In-hospital Mortality Rates in SARS-CoV-2 Patients Treated with Enoxaparin and Heparin Alroomi, Moudhi Alsaber, Ahmad Al-Bader, Bader Almutairi, Farah Malhas, Haya Pan, Jiazhu Zhanna, Kobalava D. Ramadhan, Maryam Saleh, Mohammad Al Abdullah, Mohammed Alotaibi, Naser AlNasrallah, Noor Rajan, Rajesh Hussein, Soumoud Aboelhassan, Wael Clin Appl Thromb Hemost Original Manuscript OBJECTIVES: This study aimed to investigate in-hospital mortality rates in patients with coronavirus disease (COVID-19) according to enoxaparin and heparin use. METHODS: This retrospective cohort study included 962 patients admitted to two hospitals in Kuwait with a confirmed diagnosis of COVID-19. Cumulative all-cause mortality rate was the primary outcome. RESULTS: A total of 302 patients (males, 196 [64.9%]; mean age, 57.2 ± 14.6 years; mean body mass index, 29.8 ± 6.5 kg/m(2)) received anticoagulation therapy. Patients receiving anticoagulation treatment tended to have pneumonia (n = 275 [91.1%]) or acute respiratory distress syndrome (n = 106 [35.1%]), and high D-dimer levels (median [interquartile range]: 608 [523;707] ng/mL). The mortality rate in this group was high (n = 63 [20.9%]). Multivariable logistic regression, the Cox proportional hazards, and Kaplan-Meier models revealed that the use of therapeutic anticoagulation agents affected the risk of all-cause cumulative mortality. CONCLUSION: Age, hypertension, pneumonia, therapeutic anticoagulation, and methylprednisolone use were found to be strong predictors of in-hospital mortality. In elderly hypertensive COVID-19 patients on therapeutic anticoagulation were found to have 2.3 times higher risk of in-hospital mortality. All cause in-hospital mortality rate in the therapeutic anticoagulation group was up to 21%. SAGE Publications 2022-10-25 /pmc/articles/PMC9608030/ /pubmed/36285386 http://dx.doi.org/10.1177/10760296221131802 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Manuscript
Alroomi, Moudhi
Alsaber, Ahmad
Al-Bader, Bader
Almutairi, Farah
Malhas, Haya
Pan, Jiazhu
Zhanna, Kobalava D.
Ramadhan, Maryam
Saleh, Mohammad Al
Abdullah, Mohammed
Alotaibi, Naser
AlNasrallah, Noor
Rajan, Rajesh
Hussein, Soumoud
Aboelhassan, Wael
In-hospital Mortality Rates in SARS-CoV-2 Patients Treated with Enoxaparin and Heparin
title In-hospital Mortality Rates in SARS-CoV-2 Patients Treated with Enoxaparin and Heparin
title_full In-hospital Mortality Rates in SARS-CoV-2 Patients Treated with Enoxaparin and Heparin
title_fullStr In-hospital Mortality Rates in SARS-CoV-2 Patients Treated with Enoxaparin and Heparin
title_full_unstemmed In-hospital Mortality Rates in SARS-CoV-2 Patients Treated with Enoxaparin and Heparin
title_short In-hospital Mortality Rates in SARS-CoV-2 Patients Treated with Enoxaparin and Heparin
title_sort in-hospital mortality rates in sars-cov-2 patients treated with enoxaparin and heparin
topic Original Manuscript
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608030/
https://www.ncbi.nlm.nih.gov/pubmed/36285386
http://dx.doi.org/10.1177/10760296221131802
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