Cargando…

No evidence for a difference in lateralization and distinctiveness level of transcranial magnetic stimulation-derived cortical motor representations over the adult lifespan

This study aimed to investigate the presence and patterns of age-related differences in TMS-based measures of lateralization and distinctiveness of the cortical motor representations of two different hand muscles. In a sample of seventy-three right-handed healthy participants over the adult lifespan...

Descripción completa

Detalles Bibliográficos
Autores principales: Hehl, Melina, Swinnen, Stephan P., Van Malderen, Shanti, Cuypers, Koen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608504/
https://www.ncbi.nlm.nih.gov/pubmed/36313026
http://dx.doi.org/10.3389/fnagi.2022.971858
_version_ 1784818788108075008
author Hehl, Melina
Swinnen, Stephan P.
Van Malderen, Shanti
Cuypers, Koen
author_facet Hehl, Melina
Swinnen, Stephan P.
Van Malderen, Shanti
Cuypers, Koen
author_sort Hehl, Melina
collection PubMed
description This study aimed to investigate the presence and patterns of age-related differences in TMS-based measures of lateralization and distinctiveness of the cortical motor representations of two different hand muscles. In a sample of seventy-three right-handed healthy participants over the adult lifespan, the first dorsal interosseus (FDI) and abductor digiti minimi (ADM) cortical motor representations of both hemispheres were acquired using transcranial magnetic stimulation (TMS). In addition, dexterity and maximum force levels were measured. Lateralization quotients were calculated for homolog behavioral and TMS measures, whereas the distinctiveness between the FDI and ADM representation within one hemisphere was quantified by the center of gravity (CoG) distance and cosine similarity. The presence and patterns of age-related changes were examined using linear, polynomial, and piecewise linear regression. No age-related differences could be identified for the lateralization quotient of behavior or cortical motor representations of both intrinsic hand muscles. Furthermore, no evidence for a change in the distinctiveness of the FDI and ADM representation with advancing age was found. In conclusion this work showed that lateralization and distinctiveness of cortical motor representations, as determined by means of TMS-based measures, remain stable over the adult lifespan.
format Online
Article
Text
id pubmed-9608504
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-96085042022-10-28 No evidence for a difference in lateralization and distinctiveness level of transcranial magnetic stimulation-derived cortical motor representations over the adult lifespan Hehl, Melina Swinnen, Stephan P. Van Malderen, Shanti Cuypers, Koen Front Aging Neurosci Neuroscience This study aimed to investigate the presence and patterns of age-related differences in TMS-based measures of lateralization and distinctiveness of the cortical motor representations of two different hand muscles. In a sample of seventy-three right-handed healthy participants over the adult lifespan, the first dorsal interosseus (FDI) and abductor digiti minimi (ADM) cortical motor representations of both hemispheres were acquired using transcranial magnetic stimulation (TMS). In addition, dexterity and maximum force levels were measured. Lateralization quotients were calculated for homolog behavioral and TMS measures, whereas the distinctiveness between the FDI and ADM representation within one hemisphere was quantified by the center of gravity (CoG) distance and cosine similarity. The presence and patterns of age-related changes were examined using linear, polynomial, and piecewise linear regression. No age-related differences could be identified for the lateralization quotient of behavior or cortical motor representations of both intrinsic hand muscles. Furthermore, no evidence for a change in the distinctiveness of the FDI and ADM representation with advancing age was found. In conclusion this work showed that lateralization and distinctiveness of cortical motor representations, as determined by means of TMS-based measures, remain stable over the adult lifespan. Frontiers Media S.A. 2022-10-13 /pmc/articles/PMC9608504/ /pubmed/36313026 http://dx.doi.org/10.3389/fnagi.2022.971858 Text en Copyright © 2022 Hehl, Swinnen, Van Malderen and Cuypers. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Hehl, Melina
Swinnen, Stephan P.
Van Malderen, Shanti
Cuypers, Koen
No evidence for a difference in lateralization and distinctiveness level of transcranial magnetic stimulation-derived cortical motor representations over the adult lifespan
title No evidence for a difference in lateralization and distinctiveness level of transcranial magnetic stimulation-derived cortical motor representations over the adult lifespan
title_full No evidence for a difference in lateralization and distinctiveness level of transcranial magnetic stimulation-derived cortical motor representations over the adult lifespan
title_fullStr No evidence for a difference in lateralization and distinctiveness level of transcranial magnetic stimulation-derived cortical motor representations over the adult lifespan
title_full_unstemmed No evidence for a difference in lateralization and distinctiveness level of transcranial magnetic stimulation-derived cortical motor representations over the adult lifespan
title_short No evidence for a difference in lateralization and distinctiveness level of transcranial magnetic stimulation-derived cortical motor representations over the adult lifespan
title_sort no evidence for a difference in lateralization and distinctiveness level of transcranial magnetic stimulation-derived cortical motor representations over the adult lifespan
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608504/
https://www.ncbi.nlm.nih.gov/pubmed/36313026
http://dx.doi.org/10.3389/fnagi.2022.971858
work_keys_str_mv AT hehlmelina noevidenceforadifferenceinlateralizationanddistinctivenessleveloftranscranialmagneticstimulationderivedcorticalmotorrepresentationsovertheadultlifespan
AT swinnenstephanp noevidenceforadifferenceinlateralizationanddistinctivenessleveloftranscranialmagneticstimulationderivedcorticalmotorrepresentationsovertheadultlifespan
AT vanmalderenshanti noevidenceforadifferenceinlateralizationanddistinctivenessleveloftranscranialmagneticstimulationderivedcorticalmotorrepresentationsovertheadultlifespan
AT cuyperskoen noevidenceforadifferenceinlateralizationanddistinctivenessleveloftranscranialmagneticstimulationderivedcorticalmotorrepresentationsovertheadultlifespan