Cargando…

Blood–Brain Barrier Transport of Transferrin Receptor-Targeted Nanoparticles

The blood–brain barrier (BBB), built by brain endothelial cells (BECs), is impermeable to biologics. Liposomes and other nanoparticles are good candidates for the delivery of biologics across the BECs, as they can encapsulate numerous molecules of interest in an omnipotent manner. The liposomes need...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thomsen, Maj Schneider, Johnsen, Kasper Bendix, Kucharz, Krzysztof, Lauritzen, Martin, Moos, Torben
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608573/ https://www.ncbi.nlm.nih.gov/pubmed/36297671 http://dx.doi.org/10.3390/pharmaceutics14102237

Ejemplares similares

Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles
por: Johnsen, Kasper Bendix, et al.
Publicado: (2018)

Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma
por: Johnsen, Kasper Bendix, et al.
Publicado: (2017)

Post-capillary venules are the key locus for transcytosis-mediated brain delivery of therapeutic nanoparticles
por: Kucharz, Krzysztof, et al.
Publicado: (2021)

Divalent metal transporter 1 (DMT1) in the brain: implications for a role in iron transport at the blood-brain barrier, and neuronal and glial pathology
por: Skjørringe, Tina, et al.
Publicado: (2015)

The blood-brain barrier studied in vitro across species
por: Thomsen, Maj Schneider, et al.
Publicado: (2021)

Transfection of brain capillary endothelial cells in primary culture with defined blood–brain barrier properties
por: Burkhart, Annette, et al.
Publicado: (2015)

Apolipoprotein M-bound sphingosine-1-phosphate regulates blood–brain barrier paracellular permeability and transcytosis
por: Mathiesen Janiurek, Mette, et al.
Publicado: (2019)

Kinetics of Blood–Brain Barrier Transport of Monoclonal Antibodies Targeting the Insulin Receptor and the Transferrin Receptor
por: Pardridge, William M.
Publicado: (2021)

Preserved blood-brain barrier and neurovascular coupling in female 5xFAD model of Alzheimer’s disease
por: Zhukov, Oleg, et al.
Publicado: (2023)

Mathematical Models of Blood-Brain Barrier Transport of Monoclonal Antibodies Targeting the Transferrin Receptor and the Insulin Receptor
por: Pardridge, William M., et al.
Publicado: (2021)

Iron deposits in the chronically inflamed central nervous system and contributes to neurodegeneration
por: Andersen, Hjalte Holm, et al.
Publicado: (2013)

A Triple Culture Model of the Blood-Brain Barrier Using Porcine Brain Endothelial cells, Astrocytes and Pericytes
por: Thomsen, Louiza Bohn, et al.
Publicado: (2015)

Pathogenic bacteria exploit transferrin receptor transcytosis to penetrate the blood–brain barrier
por: Cheng, Zhihui, et al.
Publicado: (2023)

Questions about horse spleen ferritin crossing the blood brain barrier via mouse transferrin receptor 1
por: Fan, Kelong, et al.
Publicado: (2017)

A Blood-Brain-Barrier-Penetrating Anti-human Transferrin Receptor Antibody Fusion Protein for Neuronopathic Mucopolysaccharidosis II
por: Sonoda, Hiroyuki, et al.
Publicado: (2018)

Ferroptosis is critical for phthalates driving the blood-testis barrier dysfunction via targeting transferrin receptor
por: Zhao, Yi, et al.
Publicado: (2022)

Transferrin Receptor-Targeted Nanocarriers: Overcoming Barriers to Treat Glioblastoma
por: Ramalho, Maria João, et al.
Publicado: (2022)

Delivery of Nanoparticles across the Intestinal Epithelium via the Transferrin Transport Pathway
por: Yong, Jing M., et al.
Publicado: (2019)

Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood–Brain Barrier Adherence, Uptake, and Permeation
por: Kristensen, Mie, et al.
Publicado: (2020)

FLCN regulates transferrin receptor 1 transport and iron homeostasis
por: Wang, Xiaojuan, et al.
Publicado: (2021)

Apo- and holo- transferrin differentially interact with ferroportin and hephaestin to regulate iron release at the blood-brain barrier
por: Baringer, Stephanie L., et al.
Publicado: (2023)

Apo- and holo- transferrin differentially interact with ferroportin and hephaestin to regulate iron release at the blood-brain barrier
por: Baringer, Stephanie, et al.
Publicado: (2023)

Rapid endocytosis of the transferrin receptor in the absence of bound transferrin
Publicado: (1985)

Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes
Publicado: (1983)

Quantitative analysis of nanoparticle transport through in vitro blood-brain barrier models
por: Åberg, Christoffer
Publicado: (2016)

Microengineered human blood–brain barrier platform for understanding nanoparticle transport mechanisms
por: Ahn, Song Ih, et al.
Publicado: (2020)

Intracellular sorting and transcytosis of the rat transferrin receptor antibody OX26 across the blood–brain barrier in vitro is dependent on its binding affinity
por: Haqqani, Arsalan S., et al.
Publicado: (2018)

Enhanced in vivo blood brain barrier transcytosis of macromolecular cargo using an engineered pH-sensitive mouse transferrin receptor binding nanobody
por: Esparza, Thomas J., et al.
Publicado: (2023)

A Perfused In Vitro Human iPSC-Derived Blood–Brain Barrier Faithfully Mimics Transferrin Receptor-Mediated Transcytosis of Therapeutic Antibodies
por: Burgio, Floriana, et al.
Publicado: (2023)

Standardized Preclinical In Vitro Blood–Brain Barrier Mouse Assay Validates Endocytosis-Dependent Antibody Transcytosis Using Transferrin-Receptor-Mediated Pathways
por: Morrison, Jamie I., et al.
Publicado: (2023)

Transferrin Receptors in Erythropoiesis
por: Richard, Cyrielle, et al.
Publicado: (2020)

A novel strategy for delivering Niemann‐Pick type C2 proteins across the blood–brain barrier using the brain endothelial‐specific AAV‐BR1 virus
por: Rasmussen, Charlotte Laurfelt Munch, et al.
Publicado: (2022)

Role of transferrin, transferrin receptors, and iron in macrophage listericidal activity
Publicado: (1991)

Brain microvascular endothelial cells derived from human induced pluripotent stem cells as in vitro model for assessing blood-brain barrier transferrin receptor-mediated transcytosis
por: Piantino, Marie, et al.
Publicado: (2022)

Transferrin-modified chitosan nanoparticles for targeted nose-to-brain delivery of proteins
por: Gabold, Bettina, et al.
Publicado: (2022)

Transporter protein and drug-conjugated gold nanoparticles capable of bypassing the blood-brain barrier
por: Zhang, Yanhua, et al.
Publicado: (2016)

Transferrin Receptor-Targeted Iduronate-2-sulfatase Penetrates the Blood-Retinal Barrier and Improves Retinopathy in Mucopolysaccharidosis II Mice
por: Imakiire, Atsushi, et al.
Publicado: (2023)

Transferrin-binding protein complex is the receptor for transferrin uptake in Trypanosoma brucei
Publicado: (1995)

An Affibody Molecule Is Actively Transported into the Cerebrospinal Fluid via Binding to the Transferrin Receptor
por: Meister, Sebastian W., et al.
Publicado: (2020)

Drug Transport and Metabolism in the Blood–Brain Barrier
por: Kapitulnik, Jaime
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_v2ipfgsha0pr5i6mfi5chhravv