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Anti-Gouty Arthritis and Anti-Hyperuricemia Properties of Sanghuangporus vaninii and Inonotus hispidus in Rodent Models

Acute inflammation and hyperuricemia are associated with gouty arthritis. As an edible and therapeutic mushroom, Sanghuangporus vaninii (SV) has an inhibitory effect on tumorigenesis, and Inonotus hispidus (IH) exhibits anti-tumor, anti-inflammatory, and antioxidant properties. In this study, uric a...

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Autores principales: Sun, Zhen, Li, Zhige, Tan, Yunyun, Wang, Xiuxiu, Wang, Chunxia, Dong, Mingyuan, Liu, Honghan, Chen, Heng, Li, Yu, Li, Lanzhou, Wang, Di
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608739/
https://www.ncbi.nlm.nih.gov/pubmed/36297105
http://dx.doi.org/10.3390/nu14204421
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author Sun, Zhen
Li, Zhige
Tan, Yunyun
Wang, Xiuxiu
Wang, Chunxia
Dong, Mingyuan
Liu, Honghan
Chen, Heng
Li, Yu
Li, Lanzhou
Wang, Di
author_facet Sun, Zhen
Li, Zhige
Tan, Yunyun
Wang, Xiuxiu
Wang, Chunxia
Dong, Mingyuan
Liu, Honghan
Chen, Heng
Li, Yu
Li, Lanzhou
Wang, Di
author_sort Sun, Zhen
collection PubMed
description Acute inflammation and hyperuricemia are associated with gouty arthritis. As an edible and therapeutic mushroom, Sanghuangporus vaninii (SV) has an inhibitory effect on tumorigenesis, and Inonotus hispidus (IH) exhibits anti-tumor, anti-inflammatory, and antioxidant properties. In this study, uric acid (UA) and xanthine oxidase (XOD) levels in hyperuricemic mice were examined to determine the regulatory effects of SV and IH. SV and IH reversed the pathogenic state of elevated UA levels in the serum and reduced levels of XOD in the serum and liver of mice with hyperuricemia. SV and IH affected the inflammatory response in rats with acute gouty arthritis. Compared to vehicle-treated rats, monosodium urate crystals (MSU) increased the swelling ratio of the right ankle joints. SV and IH administration significantly reduced swelling and inflammatory cell infiltration. SV reduced the levels of interleukin-8 (IL-8) and chemokine ligand-2 (CCL-2), whereas IH reduced the levels of matrix metalloproteinase-9 (MMP-9), CCL-2, and tumor necrosis factor-α (TNF-α), which were confirmed in articular soft tissues by immunohistochemistry. In summary, our data provide experimental evidence for the applicability of SV and IH in gouty arthritis and hyperuricemia treatment.
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spelling pubmed-96087392022-10-28 Anti-Gouty Arthritis and Anti-Hyperuricemia Properties of Sanghuangporus vaninii and Inonotus hispidus in Rodent Models Sun, Zhen Li, Zhige Tan, Yunyun Wang, Xiuxiu Wang, Chunxia Dong, Mingyuan Liu, Honghan Chen, Heng Li, Yu Li, Lanzhou Wang, Di Nutrients Article Acute inflammation and hyperuricemia are associated with gouty arthritis. As an edible and therapeutic mushroom, Sanghuangporus vaninii (SV) has an inhibitory effect on tumorigenesis, and Inonotus hispidus (IH) exhibits anti-tumor, anti-inflammatory, and antioxidant properties. In this study, uric acid (UA) and xanthine oxidase (XOD) levels in hyperuricemic mice were examined to determine the regulatory effects of SV and IH. SV and IH reversed the pathogenic state of elevated UA levels in the serum and reduced levels of XOD in the serum and liver of mice with hyperuricemia. SV and IH affected the inflammatory response in rats with acute gouty arthritis. Compared to vehicle-treated rats, monosodium urate crystals (MSU) increased the swelling ratio of the right ankle joints. SV and IH administration significantly reduced swelling and inflammatory cell infiltration. SV reduced the levels of interleukin-8 (IL-8) and chemokine ligand-2 (CCL-2), whereas IH reduced the levels of matrix metalloproteinase-9 (MMP-9), CCL-2, and tumor necrosis factor-α (TNF-α), which were confirmed in articular soft tissues by immunohistochemistry. In summary, our data provide experimental evidence for the applicability of SV and IH in gouty arthritis and hyperuricemia treatment. MDPI 2022-10-21 /pmc/articles/PMC9608739/ /pubmed/36297105 http://dx.doi.org/10.3390/nu14204421 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sun, Zhen
Li, Zhige
Tan, Yunyun
Wang, Xiuxiu
Wang, Chunxia
Dong, Mingyuan
Liu, Honghan
Chen, Heng
Li, Yu
Li, Lanzhou
Wang, Di
Anti-Gouty Arthritis and Anti-Hyperuricemia Properties of Sanghuangporus vaninii and Inonotus hispidus in Rodent Models
title Anti-Gouty Arthritis and Anti-Hyperuricemia Properties of Sanghuangporus vaninii and Inonotus hispidus in Rodent Models
title_full Anti-Gouty Arthritis and Anti-Hyperuricemia Properties of Sanghuangporus vaninii and Inonotus hispidus in Rodent Models
title_fullStr Anti-Gouty Arthritis and Anti-Hyperuricemia Properties of Sanghuangporus vaninii and Inonotus hispidus in Rodent Models
title_full_unstemmed Anti-Gouty Arthritis and Anti-Hyperuricemia Properties of Sanghuangporus vaninii and Inonotus hispidus in Rodent Models
title_short Anti-Gouty Arthritis and Anti-Hyperuricemia Properties of Sanghuangporus vaninii and Inonotus hispidus in Rodent Models
title_sort anti-gouty arthritis and anti-hyperuricemia properties of sanghuangporus vaninii and inonotus hispidus in rodent models
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608739/
https://www.ncbi.nlm.nih.gov/pubmed/36297105
http://dx.doi.org/10.3390/nu14204421
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