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First Genomic Evidence of a Henipa-like Virus in Brazil

The viral genus Henipavirus includes two highly virulent zoonotic viruses of serious public health concern. Hendra henipavirus and Nipah henipavirus outbreaks are restricted to Australia and Southeast Asia, respectively. The Henipavirus genus comprises mostly bat-borne viruses, but exceptions have a...

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Autores principales: Hernández, Leonardo H. Almeida, da Paz, Thito Y. Bezerra, da Silva, Sandro Patroca, da Silva, Fábio S., de Barros, Bruno C. Veloso, Nunes, Bruno T. Diniz, Casseb, Lívia M. Neves, Medeiros, Daniele B. Almeida, Vasconcelos, Pedro F. da Costa, Cruz, Ana C. Ribeiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608811/
https://www.ncbi.nlm.nih.gov/pubmed/36298723
http://dx.doi.org/10.3390/v14102167
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author Hernández, Leonardo H. Almeida
da Paz, Thito Y. Bezerra
da Silva, Sandro Patroca
da Silva, Fábio S.
de Barros, Bruno C. Veloso
Nunes, Bruno T. Diniz
Casseb, Lívia M. Neves
Medeiros, Daniele B. Almeida
Vasconcelos, Pedro F. da Costa
Cruz, Ana C. Ribeiro
author_facet Hernández, Leonardo H. Almeida
da Paz, Thito Y. Bezerra
da Silva, Sandro Patroca
da Silva, Fábio S.
de Barros, Bruno C. Veloso
Nunes, Bruno T. Diniz
Casseb, Lívia M. Neves
Medeiros, Daniele B. Almeida
Vasconcelos, Pedro F. da Costa
Cruz, Ana C. Ribeiro
author_sort Hernández, Leonardo H. Almeida
collection PubMed
description The viral genus Henipavirus includes two highly virulent zoonotic viruses of serious public health concern. Hendra henipavirus and Nipah henipavirus outbreaks are restricted to Australia and Southeast Asia, respectively. The Henipavirus genus comprises mostly bat-borne viruses, but exceptions have already been described as novel viruses with rodents and shrews as reservoir animals. In the Americas, scarce evidence supports the circulation of these viruses. In this communication, we report a novel henipa-like virus from opossums (Marmosa demerarae) from a forest fragment area in the Peixe-Boi municipality, Brazil, after which the virus was named the Peixe-Boi virus (PBV). The application of next-generation sequencing and metagenomic approach led us to discover the original evidence of a henipa-like virus genome in Brazil and South America and the original description of a henipa-like virus in marsupial species. These findings emphasize the importance of further studies to characterize PBV and clarify its ecology, impact on public health, and its relationship with didelphid marsupials and henipaviruses.
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spelling pubmed-96088112022-10-28 First Genomic Evidence of a Henipa-like Virus in Brazil Hernández, Leonardo H. Almeida da Paz, Thito Y. Bezerra da Silva, Sandro Patroca da Silva, Fábio S. de Barros, Bruno C. Veloso Nunes, Bruno T. Diniz Casseb, Lívia M. Neves Medeiros, Daniele B. Almeida Vasconcelos, Pedro F. da Costa Cruz, Ana C. Ribeiro Viruses Communication The viral genus Henipavirus includes two highly virulent zoonotic viruses of serious public health concern. Hendra henipavirus and Nipah henipavirus outbreaks are restricted to Australia and Southeast Asia, respectively. The Henipavirus genus comprises mostly bat-borne viruses, but exceptions have already been described as novel viruses with rodents and shrews as reservoir animals. In the Americas, scarce evidence supports the circulation of these viruses. In this communication, we report a novel henipa-like virus from opossums (Marmosa demerarae) from a forest fragment area in the Peixe-Boi municipality, Brazil, after which the virus was named the Peixe-Boi virus (PBV). The application of next-generation sequencing and metagenomic approach led us to discover the original evidence of a henipa-like virus genome in Brazil and South America and the original description of a henipa-like virus in marsupial species. These findings emphasize the importance of further studies to characterize PBV and clarify its ecology, impact on public health, and its relationship with didelphid marsupials and henipaviruses. MDPI 2022-09-30 /pmc/articles/PMC9608811/ /pubmed/36298723 http://dx.doi.org/10.3390/v14102167 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Hernández, Leonardo H. Almeida
da Paz, Thito Y. Bezerra
da Silva, Sandro Patroca
da Silva, Fábio S.
de Barros, Bruno C. Veloso
Nunes, Bruno T. Diniz
Casseb, Lívia M. Neves
Medeiros, Daniele B. Almeida
Vasconcelos, Pedro F. da Costa
Cruz, Ana C. Ribeiro
First Genomic Evidence of a Henipa-like Virus in Brazil
title First Genomic Evidence of a Henipa-like Virus in Brazil
title_full First Genomic Evidence of a Henipa-like Virus in Brazil
title_fullStr First Genomic Evidence of a Henipa-like Virus in Brazil
title_full_unstemmed First Genomic Evidence of a Henipa-like Virus in Brazil
title_short First Genomic Evidence of a Henipa-like Virus in Brazil
title_sort first genomic evidence of a henipa-like virus in brazil
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608811/
https://www.ncbi.nlm.nih.gov/pubmed/36298723
http://dx.doi.org/10.3390/v14102167
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