Cargando…

Topical Tirbanibulin, a Dual Src Kinase and Tubulin Polymerization Inhibitor, for the Treatment of Plaque-Type Psoriasis: Phase I Results

Plaque-type psoriasis is a common skin disorder. Tirbanibulin (KX01) is a new Src kinase inhibitor with potent antiproliferative activity against keratinocytes and has been approved for treatment of actinic keratosis. This Phase I study investigates the safety and activity of KX01 ointment in patien...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hong, Jin-Bon, Wu, Po-Yuan, Qin, Albert, Huang, Yi-Wen, Tseng, Kuan-Chiao, Lai, Ching-Yu, Chan, Wing-Kai, Fang, Jane, Cutler, David L., Tsai, Tsen-Fang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608911/ https://www.ncbi.nlm.nih.gov/pubmed/36297594 http://dx.doi.org/10.3390/pharmaceutics14102159

Ejemplares similares

Tirbanibulin Attenuates Pulmonary Fibrosis by Modulating Src/STAT3 Signaling
por: Wang, Xin, et al.
Publicado: (2021)

Topical tirbanibulin eradication of periungual squamous cell carcinoma
por: Moore, Angela Yen, et al.
Publicado: (2021)

Contact Sensitization and Phototoxic and Photoallergic Potential of Tirbanibulin 1% Ointment in Healthy Volunteers
por: Dosik, Jonathan, et al.
Publicado: (2022)

Rapid resolution of recalcitrant basal cell carcinoma of the ear with topical tirbanibulin
por: Moore, Angela, et al.
Publicado: (2022)

Topical tirbanibulin resolves recalcitrant condyloma acuminata: Retrospective case series
por: Moore, Angela Yen, et al.
Publicado: (2023)

Human papillomavirus 57 positivity in periungual squamous cell carcinoma eradicated by topical tirbanibulin
por: Moore, Angela Yen, et al.
Publicado: (2022)

1% Tirbanibulin Ointment for the Treatment of Actinic Keratoses
por: Dao, Diem-Phuong D., et al.
Publicado: (2021)

Tirbanibulin for Actinic Keratosis: Insights into the Mechanism of Action
por: Schlesinger, Todd, et al.
Publicado: (2022)

Real-world experience with histological confirmation of clinical response of squamous cell carcinoma to topical tirbanibulin
por: Moore, Angela, et al.
Publicado: (2023)

Economic Evaluation of Tirbanibulin for the Treatment of Actinic Keratosis in Scotland
por: Dymond, Amy, et al.
Publicado: (2023)

KC-180-2 Exerts Anti-SCLC Effects via Dual Inhibition of Tubulin Polymerization and Src Signaling
por: Peng, Jian, et al.
Publicado: (2022)

Updates on the Treatment of Erythrodermic Psoriasis
por: Lo, Yang, et al.
Publicado: (2021)

Spotlight on Topical Long-Term Management of Plaque Psoriasis
por: Carrascosa, Jose Manuel, et al.
Publicado: (2020)

HLA-Cw1 and Psoriasis
por: Huang, Yi-Wei, et al.
Publicado: (2021)

Efficacy of adding topical simvastatin to topical calcipotriol on improvement of cutaneous plaque psoriasis
por: Iraji, Fariba, et al.
Publicado: (2014)

Physiological regulation of total tubulin and polymerized tubulin in tissues
Publicado: (1977)

Topical and Oral Therapies for Childhood Atopic Dermatitis and Plaque Psoriasis
por: Frantz, Travis, et al.
Publicado: (2019)

Sulfhydryls and the in vitro polymerization of tubulin
Publicado: (1976)

Overlapping Features of Psoriasis and Atopic Dermatitis: From Genetics to Immunopathogenesis to Phenotypes
por: Tsai, Ya-Chu, et al.
Publicado: (2022)

Psoriasis and Co-morbidity
por: AMIN, Mina, et al.
Publicado: (2020)

Treatment Response of Patients with Erythrodermic Psoriasis after Switching to Guselkumab
por: Chiang, Cheng-Ying, et al.
Publicado: (2021)

Novel topical therapy for mild-to-moderate plaque psoriasis: focus on calcitriol
por: Kowalzick, Lutz
Publicado: (2009)

Topical Turmeric Microemulgel in the Management of Plaque Psoriasis; A Clinical Evaluation
por: Sarafian, Golnaz, et al.
Publicado: (2015)

1% Tirbanibulin Ointment for Actinic Keratoses on Upper Extremities: A Retrospective Case Review Study
por: IGLESIAS-PUZAS, Álvaro, et al.
Publicado: (2023)

The MARCOPOLO Study of Ustekinumab Utilization and Efficacy in a Real-World Setting: Treatment of Patients with Plaque Psoriasis in Asia-Pacific Countries
por: Youn, Sang Woong, et al.
Publicado: (2016)

Taxol binds to polymerized tubulin in vitro
por: Parness, J, et al.
Publicado: (1981)

Exacerbation of Psoriasis Following COVID-19 Vaccination: Report From a Single Center
por: Huang, Yi-Wei, et al.
Publicado: (2021)

Phenothiazine- and Carbazole-Cyanochalcones as Dual Inhibitors of Tubulin Polymerization and Human Farnesyltransferase
por: Zubaș, Andreea, et al.
Publicado: (2023)

Asian consensus on assessment and management of mild to moderate plaque psoriasis with topical therapy
por: Imafuku, Shinichi, et al.
Publicado: (2018)

Combination Therapy for Psoriasis with Methotrexate and Other Oral Disease-Modifying Antirheumatic Drugs: A Systematic Review
por: Hsieh, Tyng-Shiuan, et al.
Publicado: (2023)

Antitumour potential of BPT: a dual inhibitor of cdk4 and tubulin polymerization
por: Mahale, S, et al.
Publicado: (2015)

Quinazolinone-Amino Acid Hybrids as Dual Inhibitors of EGFR Kinase and Tubulin Polymerization
por: Zayed, Mohamed F., et al.
Publicado: (2018)

Guselkumab for plaque psoriasis
Publicado: (2019)

Bimekizumab for plaque psoriasis
Publicado: (2022)

An Open-Label Study of an Herbal Topical Medication (QoolSkin) for Patients with Chronic Plaque Psoriasis
por: Cohen, Arnon D., et al.
Publicado: (2007)

Change of Oral to Topical Corticosteroid Therapy Exacerbated Glucose Tolerance in a Patient with Plaque Psoriasis
por: Hongo, Yui, et al.
Publicado: (2017)

Predictive Value of NUDT15 Variants on Neutropenia Among Han Chinese Patients with Dermatologic Diseases: A Single-Center Observational Study
por: Huang, Po-Wei, et al.
Publicado: (2020)

Tubulin is phosphorylated at tyrosine by pp60c-src in nerve growth cone membranes
Publicado: (1990)

Apremilast in the Treatment of Plaque Psoriasis: Differential Use in Psoriasis
por: Gao, Jia C, et al.
Publicado: (2022)

Etanercept in the treatment of plaque psoriasis
por: Nguyen, Thao U, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_a79cd18kd9t3mngbovpsi2vmlu