Cargando…

Is Season of Diagnosis a Predictor of Cancer Survival? Results from the Zurich Cancer Registry

In Switzerland, there is a large seasonal variation in sunlight, and vitamin D deficiency is relatively common during winter. The season of diagnosis may be linked to cancer survival via vitamin D status. Using data from the Cancer Registry of Zurich, Zug, Schaffhausen, and Schwyz with more than 171...

Descripción completa

Detalles Bibliográficos
Autores principales: Hysaj, Ola, Karavasiloglou, Nena, Limam, Manuela, Wanner, Miriam, Korol, Dimitri, Rohrmann, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608958/
https://www.ncbi.nlm.nih.gov/pubmed/36296975
http://dx.doi.org/10.3390/nu14204291
_version_ 1784818896050585600
author Hysaj, Ola
Karavasiloglou, Nena
Limam, Manuela
Wanner, Miriam
Korol, Dimitri
Rohrmann, Sabine
author_facet Hysaj, Ola
Karavasiloglou, Nena
Limam, Manuela
Wanner, Miriam
Korol, Dimitri
Rohrmann, Sabine
author_sort Hysaj, Ola
collection PubMed
description In Switzerland, there is a large seasonal variation in sunlight, and vitamin D deficiency is relatively common during winter. The season of diagnosis may be linked to cancer survival via vitamin D status. Using data from the Cancer Registry of Zurich, Zug, Schaffhausen, and Schwyz with more than 171,000 cancer cases registered since 1980, we examined the association of the season of diagnosis with survival for cancers including prostate (ICD10 code C61; International Categorization of Diseases, version 10), breast (C50), colorectal (C18-21), lung (C34), melanoma (C43), and all sites combined. Cox proportional hazards regression models were used to assess the differences in the all-cause mortality by the season of the diagnosis. Winter was used as the reference season. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated for all the cancers combined (excluding nonmelanoma skin cancer) and for prostate (in men), breast (in women), colorectal, lung cancer, and melanomas, separately. A diagnosis in summer and/or autumn was associated with improved survival in all the sites combined for both sexes (men: HR 0.97 [95% CI 0.96–0.99]; women: HR 0.97 [95% CI 0.94–0.99]) and in colorectal (HR 0.91 [95% CI 0.84–0.99]), melanoma (HR 0.81 [95% CI 0.65–1.00]), and breast cancer (HR 0.91 [95% CI 0.94–0.99]) in women. Our study results suggest that a cancer diagnosis in summer and/or autumn is associated with a better prognosis. The improved seasonal survival coincides with the seasonal variation of sun-induced vitamin D, and vitamin D may play a protective and beneficial role in cancer survival.
format Online
Article
Text
id pubmed-9608958
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96089582022-10-28 Is Season of Diagnosis a Predictor of Cancer Survival? Results from the Zurich Cancer Registry Hysaj, Ola Karavasiloglou, Nena Limam, Manuela Wanner, Miriam Korol, Dimitri Rohrmann, Sabine Nutrients Article In Switzerland, there is a large seasonal variation in sunlight, and vitamin D deficiency is relatively common during winter. The season of diagnosis may be linked to cancer survival via vitamin D status. Using data from the Cancer Registry of Zurich, Zug, Schaffhausen, and Schwyz with more than 171,000 cancer cases registered since 1980, we examined the association of the season of diagnosis with survival for cancers including prostate (ICD10 code C61; International Categorization of Diseases, version 10), breast (C50), colorectal (C18-21), lung (C34), melanoma (C43), and all sites combined. Cox proportional hazards regression models were used to assess the differences in the all-cause mortality by the season of the diagnosis. Winter was used as the reference season. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated for all the cancers combined (excluding nonmelanoma skin cancer) and for prostate (in men), breast (in women), colorectal, lung cancer, and melanomas, separately. A diagnosis in summer and/or autumn was associated with improved survival in all the sites combined for both sexes (men: HR 0.97 [95% CI 0.96–0.99]; women: HR 0.97 [95% CI 0.94–0.99]) and in colorectal (HR 0.91 [95% CI 0.84–0.99]), melanoma (HR 0.81 [95% CI 0.65–1.00]), and breast cancer (HR 0.91 [95% CI 0.94–0.99]) in women. Our study results suggest that a cancer diagnosis in summer and/or autumn is associated with a better prognosis. The improved seasonal survival coincides with the seasonal variation of sun-induced vitamin D, and vitamin D may play a protective and beneficial role in cancer survival. MDPI 2022-10-14 /pmc/articles/PMC9608958/ /pubmed/36296975 http://dx.doi.org/10.3390/nu14204291 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hysaj, Ola
Karavasiloglou, Nena
Limam, Manuela
Wanner, Miriam
Korol, Dimitri
Rohrmann, Sabine
Is Season of Diagnosis a Predictor of Cancer Survival? Results from the Zurich Cancer Registry
title Is Season of Diagnosis a Predictor of Cancer Survival? Results from the Zurich Cancer Registry
title_full Is Season of Diagnosis a Predictor of Cancer Survival? Results from the Zurich Cancer Registry
title_fullStr Is Season of Diagnosis a Predictor of Cancer Survival? Results from the Zurich Cancer Registry
title_full_unstemmed Is Season of Diagnosis a Predictor of Cancer Survival? Results from the Zurich Cancer Registry
title_short Is Season of Diagnosis a Predictor of Cancer Survival? Results from the Zurich Cancer Registry
title_sort is season of diagnosis a predictor of cancer survival? results from the zurich cancer registry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608958/
https://www.ncbi.nlm.nih.gov/pubmed/36296975
http://dx.doi.org/10.3390/nu14204291
work_keys_str_mv AT hysajola isseasonofdiagnosisapredictorofcancersurvivalresultsfromthezurichcancerregistry
AT karavasiloglounena isseasonofdiagnosisapredictorofcancersurvivalresultsfromthezurichcancerregistry
AT limammanuela isseasonofdiagnosisapredictorofcancersurvivalresultsfromthezurichcancerregistry
AT wannermiriam isseasonofdiagnosisapredictorofcancersurvivalresultsfromthezurichcancerregistry
AT koroldimitri isseasonofdiagnosisapredictorofcancersurvivalresultsfromthezurichcancerregistry
AT rohrmannsabine isseasonofdiagnosisapredictorofcancersurvivalresultsfromthezurichcancerregistry