Metalloprotease-Dependent S2′-Activation Promotes Cell–Cell Fusion and Syncytiation of SARS-CoV-2

SARS-CoV-2 cell–cell fusion and syncytiation is an emerging pathomechanism in COVID-19, but the precise factors contributing to the process remain ill-defined. In this study, we show that metalloproteases promote SARS-CoV-2 spike protein-induced syncytiation in the absence of established serine prot...

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Detalles Bibliográficos
Autores principales: Harte, James V., Wakerlin, Samantha L., Lindsay, Andrew J., McCarthy, Justin V., Coleman-Vaughan, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608990/
https://www.ncbi.nlm.nih.gov/pubmed/36298651
http://dx.doi.org/10.3390/v14102094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608990/
https://www.ncbi.nlm.nih.gov/pubmed/36298651
http://dx.doi.org/10.3390/v14102094

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