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Dynamics of SARS-CoV-2 Variants of Concern in Vaccination Model City in the State of Sao Paulo, Brazil
From a country with one of the highest SARS-CoV-2 morbidity and mortality rates, Brazil has implemented one of the most successful vaccination programs. Brazil’s first model city vaccination program was performed by the CoronaVac vaccine (Sinovac Biotech) in the town of Serrana, São Paulo State. To...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609010/ https://www.ncbi.nlm.nih.gov/pubmed/36298703 http://dx.doi.org/10.3390/v14102148 |
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author | Slavov, Svetoslav Nanev de La-Roque, Debora Glenda Lima da Costa, Pericles Natan Mendes Rodrigues, Evandra Strazza Santos, Elaine Vieira Borges, Josiane Serrano Evaristo, Mariane de Matos Maçonetto, Juliana Marques, Adriana Aparecida Milhomens, Jonathan Rós, Felipe Augusto Fonseca, Vagner Lima, Alex Ranieri Jerônimo Ribeiro, Gabriela de Lima, Loyze Paola Oliveira Garibaldi, Pedro Manuel Marques Ferreira, Natasha Nicos Moraes, Glenda Renata Marqueze, Elaine Cristina Barros, Claudia Renata dos Santos Martins, Antonio Jorge Coutinho, Luiz Lehmann Calado, Rodrigo Tocantins Borges, Marcos Elias, Maria Carolina Sampaio, Sandra Coccuzzo Giovanetti, Marta Alcantara, Luiz Carlos Junior Covas, Dimas Tadeu Kashima, Simone |
author_facet | Slavov, Svetoslav Nanev de La-Roque, Debora Glenda Lima da Costa, Pericles Natan Mendes Rodrigues, Evandra Strazza Santos, Elaine Vieira Borges, Josiane Serrano Evaristo, Mariane de Matos Maçonetto, Juliana Marques, Adriana Aparecida Milhomens, Jonathan Rós, Felipe Augusto Fonseca, Vagner Lima, Alex Ranieri Jerônimo Ribeiro, Gabriela de Lima, Loyze Paola Oliveira Garibaldi, Pedro Manuel Marques Ferreira, Natasha Nicos Moraes, Glenda Renata Marqueze, Elaine Cristina Barros, Claudia Renata dos Santos Martins, Antonio Jorge Coutinho, Luiz Lehmann Calado, Rodrigo Tocantins Borges, Marcos Elias, Maria Carolina Sampaio, Sandra Coccuzzo Giovanetti, Marta Alcantara, Luiz Carlos Junior Covas, Dimas Tadeu Kashima, Simone |
author_sort | Slavov, Svetoslav Nanev |
collection | PubMed |
description | From a country with one of the highest SARS-CoV-2 morbidity and mortality rates, Brazil has implemented one of the most successful vaccination programs. Brazil’s first model city vaccination program was performed by the CoronaVac vaccine (Sinovac Biotech) in the town of Serrana, São Paulo State. To evaluate the vaccination effect on the SARS-CoV-2 molecular dynamics and clinical outcomes, we performed SARS-CoV-2 molecular surveillance on 4375 complete genomes obtained between June 2020 and April 2022 in this location. This study included the period between the initial SARS-CoV-2 introduction and during the vaccination process. We observed that the SARS-CoV-2 substitution dynamics in Serrana followed the viral molecular epidemiology in Brazil, including the initial identification of the ancestral lineages (B.1.1.28 and B.1.1.33) and epidemic waves of variants of concern (VOC) including the Gamma, Delta, and, more recently, Omicron. Most probably, as a result of the immunization campaign, the mortality during the Gamma and Delta VOC was significantly reduced compared to the rest of Brazil, which was also related to lower morbidity. Our phylogenetic analysis revealed the evolutionary history of the SARS-CoV-2 in this location and showed that multiple introduction events have occurred over time. The evaluation of the COVID-19 clinical outcome revealed that most cases were mild (88.9%, 98.1%, 99.1% to Gamma, Delta, and Omicron, respectively) regardless of the infecting VOC. In conclusion, we observed that vaccination was responsible for reducing the death toll rate and related COVID-19 morbidity, especially during the gamma and Delta VOC; however, it does not prevent the rapid substitution rate and morbidity of the Omicron VOC. |
format | Online Article Text |
id | pubmed-9609010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96090102022-10-28 Dynamics of SARS-CoV-2 Variants of Concern in Vaccination Model City in the State of Sao Paulo, Brazil Slavov, Svetoslav Nanev de La-Roque, Debora Glenda Lima da Costa, Pericles Natan Mendes Rodrigues, Evandra Strazza Santos, Elaine Vieira Borges, Josiane Serrano Evaristo, Mariane de Matos Maçonetto, Juliana Marques, Adriana Aparecida Milhomens, Jonathan Rós, Felipe Augusto Fonseca, Vagner Lima, Alex Ranieri Jerônimo Ribeiro, Gabriela de Lima, Loyze Paola Oliveira Garibaldi, Pedro Manuel Marques Ferreira, Natasha Nicos Moraes, Glenda Renata Marqueze, Elaine Cristina Barros, Claudia Renata dos Santos Martins, Antonio Jorge Coutinho, Luiz Lehmann Calado, Rodrigo Tocantins Borges, Marcos Elias, Maria Carolina Sampaio, Sandra Coccuzzo Giovanetti, Marta Alcantara, Luiz Carlos Junior Covas, Dimas Tadeu Kashima, Simone Viruses Article From a country with one of the highest SARS-CoV-2 morbidity and mortality rates, Brazil has implemented one of the most successful vaccination programs. Brazil’s first model city vaccination program was performed by the CoronaVac vaccine (Sinovac Biotech) in the town of Serrana, São Paulo State. To evaluate the vaccination effect on the SARS-CoV-2 molecular dynamics and clinical outcomes, we performed SARS-CoV-2 molecular surveillance on 4375 complete genomes obtained between June 2020 and April 2022 in this location. This study included the period between the initial SARS-CoV-2 introduction and during the vaccination process. We observed that the SARS-CoV-2 substitution dynamics in Serrana followed the viral molecular epidemiology in Brazil, including the initial identification of the ancestral lineages (B.1.1.28 and B.1.1.33) and epidemic waves of variants of concern (VOC) including the Gamma, Delta, and, more recently, Omicron. Most probably, as a result of the immunization campaign, the mortality during the Gamma and Delta VOC was significantly reduced compared to the rest of Brazil, which was also related to lower morbidity. Our phylogenetic analysis revealed the evolutionary history of the SARS-CoV-2 in this location and showed that multiple introduction events have occurred over time. The evaluation of the COVID-19 clinical outcome revealed that most cases were mild (88.9%, 98.1%, 99.1% to Gamma, Delta, and Omicron, respectively) regardless of the infecting VOC. In conclusion, we observed that vaccination was responsible for reducing the death toll rate and related COVID-19 morbidity, especially during the gamma and Delta VOC; however, it does not prevent the rapid substitution rate and morbidity of the Omicron VOC. MDPI 2022-09-29 /pmc/articles/PMC9609010/ /pubmed/36298703 http://dx.doi.org/10.3390/v14102148 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Slavov, Svetoslav Nanev de La-Roque, Debora Glenda Lima da Costa, Pericles Natan Mendes Rodrigues, Evandra Strazza Santos, Elaine Vieira Borges, Josiane Serrano Evaristo, Mariane de Matos Maçonetto, Juliana Marques, Adriana Aparecida Milhomens, Jonathan Rós, Felipe Augusto Fonseca, Vagner Lima, Alex Ranieri Jerônimo Ribeiro, Gabriela de Lima, Loyze Paola Oliveira Garibaldi, Pedro Manuel Marques Ferreira, Natasha Nicos Moraes, Glenda Renata Marqueze, Elaine Cristina Barros, Claudia Renata dos Santos Martins, Antonio Jorge Coutinho, Luiz Lehmann Calado, Rodrigo Tocantins Borges, Marcos Elias, Maria Carolina Sampaio, Sandra Coccuzzo Giovanetti, Marta Alcantara, Luiz Carlos Junior Covas, Dimas Tadeu Kashima, Simone Dynamics of SARS-CoV-2 Variants of Concern in Vaccination Model City in the State of Sao Paulo, Brazil |
title | Dynamics of SARS-CoV-2 Variants of Concern in Vaccination Model City in the State of Sao Paulo, Brazil |
title_full | Dynamics of SARS-CoV-2 Variants of Concern in Vaccination Model City in the State of Sao Paulo, Brazil |
title_fullStr | Dynamics of SARS-CoV-2 Variants of Concern in Vaccination Model City in the State of Sao Paulo, Brazil |
title_full_unstemmed | Dynamics of SARS-CoV-2 Variants of Concern in Vaccination Model City in the State of Sao Paulo, Brazil |
title_short | Dynamics of SARS-CoV-2 Variants of Concern in Vaccination Model City in the State of Sao Paulo, Brazil |
title_sort | dynamics of sars-cov-2 variants of concern in vaccination model city in the state of sao paulo, brazil |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609010/ https://www.ncbi.nlm.nih.gov/pubmed/36298703 http://dx.doi.org/10.3390/v14102148 |
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