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Screening for prostate cancer: protocol for updating multiple systematic reviews to inform a Canadian Task Force on Preventive Health Care guideline update
PURPOSE: To inform updated recommendations by the Canadian Task Force on Preventive Health Care on screening for prostate cancer in adults aged 18 years and older in primary care. This protocol outlines the planned scope and methods for a series of systematic reviews. METHODS: Updates of two systema...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609189/ https://www.ncbi.nlm.nih.gov/pubmed/36289518 http://dx.doi.org/10.1186/s13643-022-02099-9 |
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author | Bennett, Alexandria Beck, Andrew Shaver, Nicole Grad, Roland LeBlanc, Allana Limburg, Heather Gray, Casey Abou-Setta, Ahmed Klarenbach, Scott Persaud, Navindra Thériault, Guylène Thombs, Brett D. Todd, Keith J. Bell, Neil Dahm, Philipp Loblaw, Andrew Del Giudice, Lisa Yao, Xiaomei Skidmore, Becky Rolland-Harris, Elizabeth Brouwers, Melissa Little, Julian Moher, David |
author_facet | Bennett, Alexandria Beck, Andrew Shaver, Nicole Grad, Roland LeBlanc, Allana Limburg, Heather Gray, Casey Abou-Setta, Ahmed Klarenbach, Scott Persaud, Navindra Thériault, Guylène Thombs, Brett D. Todd, Keith J. Bell, Neil Dahm, Philipp Loblaw, Andrew Del Giudice, Lisa Yao, Xiaomei Skidmore, Becky Rolland-Harris, Elizabeth Brouwers, Melissa Little, Julian Moher, David |
author_sort | Bennett, Alexandria |
collection | PubMed |
description | PURPOSE: To inform updated recommendations by the Canadian Task Force on Preventive Health Care on screening for prostate cancer in adults aged 18 years and older in primary care. This protocol outlines the planned scope and methods for a series of systematic reviews. METHODS: Updates of two systematic reviews and a de novo review will be conducted to synthesize the evidence on the benefits and harms of screening for prostate cancer with a prostate-specific antigen (PSA) and/or digital rectal examination (DRE) (with or without additional information) and patient values and preferences. Outcomes for the benefits of screening include reduced prostate cancer mortality, all-cause mortality, and incidence of metastatic prostate cancer. Outcomes for the harms of screening include false-positive screening tests, overdiagnosis, complications due to biopsy, and complications of treatment including incontinence (urinary or bowel), and erectile dysfunction. The quality of life or functioning (overall and disease-specific) and psychological effects outcomes are considered as a possible benefit or harm. Outcomes for the values and preferences review include quantitative or qualitative information regarding the choice to screen or intention to undergo screening. For the reviews on benefits or harms, we will search for randomized controlled trials, quasi-randomized, and controlled studies in MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials. For the review on values and preferences, we will search for experimental or observational studies in MEDLINE, Embase, and PsycInfo. For all reviews, we will also search websites of relevant organizations, gray literature, and reference lists of included studies. Title and abstract screening, full-text review, data extraction, and risk of bias assessments will be completed independently by pairs of reviewers with any disagreements resolved by consensus or by consulting with a third reviewer. The GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach will be used to assess the certainty of the evidence for each outcome. DISCUSSION: The series of systematic reviews will be used by the Canadian Task Force on Preventive Health Care to update their 2014 guideline on screening for prostate cancer in adults aged 18 years and older. Systematic review registration This review has been registered with PROSPERO (CRD42022314407) and is available on the Open Science Framework (osf.io/dm32k). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13643-022-02099-9. |
format | Online Article Text |
id | pubmed-9609189 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-96091892022-10-28 Screening for prostate cancer: protocol for updating multiple systematic reviews to inform a Canadian Task Force on Preventive Health Care guideline update Bennett, Alexandria Beck, Andrew Shaver, Nicole Grad, Roland LeBlanc, Allana Limburg, Heather Gray, Casey Abou-Setta, Ahmed Klarenbach, Scott Persaud, Navindra Thériault, Guylène Thombs, Brett D. Todd, Keith J. Bell, Neil Dahm, Philipp Loblaw, Andrew Del Giudice, Lisa Yao, Xiaomei Skidmore, Becky Rolland-Harris, Elizabeth Brouwers, Melissa Little, Julian Moher, David Syst Rev Protocol PURPOSE: To inform updated recommendations by the Canadian Task Force on Preventive Health Care on screening for prostate cancer in adults aged 18 years and older in primary care. This protocol outlines the planned scope and methods for a series of systematic reviews. METHODS: Updates of two systematic reviews and a de novo review will be conducted to synthesize the evidence on the benefits and harms of screening for prostate cancer with a prostate-specific antigen (PSA) and/or digital rectal examination (DRE) (with or without additional information) and patient values and preferences. Outcomes for the benefits of screening include reduced prostate cancer mortality, all-cause mortality, and incidence of metastatic prostate cancer. Outcomes for the harms of screening include false-positive screening tests, overdiagnosis, complications due to biopsy, and complications of treatment including incontinence (urinary or bowel), and erectile dysfunction. The quality of life or functioning (overall and disease-specific) and psychological effects outcomes are considered as a possible benefit or harm. Outcomes for the values and preferences review include quantitative or qualitative information regarding the choice to screen or intention to undergo screening. For the reviews on benefits or harms, we will search for randomized controlled trials, quasi-randomized, and controlled studies in MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials. For the review on values and preferences, we will search for experimental or observational studies in MEDLINE, Embase, and PsycInfo. For all reviews, we will also search websites of relevant organizations, gray literature, and reference lists of included studies. Title and abstract screening, full-text review, data extraction, and risk of bias assessments will be completed independently by pairs of reviewers with any disagreements resolved by consensus or by consulting with a third reviewer. The GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach will be used to assess the certainty of the evidence for each outcome. DISCUSSION: The series of systematic reviews will be used by the Canadian Task Force on Preventive Health Care to update their 2014 guideline on screening for prostate cancer in adults aged 18 years and older. Systematic review registration This review has been registered with PROSPERO (CRD42022314407) and is available on the Open Science Framework (osf.io/dm32k). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13643-022-02099-9. BioMed Central 2022-10-26 /pmc/articles/PMC9609189/ /pubmed/36289518 http://dx.doi.org/10.1186/s13643-022-02099-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Protocol Bennett, Alexandria Beck, Andrew Shaver, Nicole Grad, Roland LeBlanc, Allana Limburg, Heather Gray, Casey Abou-Setta, Ahmed Klarenbach, Scott Persaud, Navindra Thériault, Guylène Thombs, Brett D. Todd, Keith J. Bell, Neil Dahm, Philipp Loblaw, Andrew Del Giudice, Lisa Yao, Xiaomei Skidmore, Becky Rolland-Harris, Elizabeth Brouwers, Melissa Little, Julian Moher, David Screening for prostate cancer: protocol for updating multiple systematic reviews to inform a Canadian Task Force on Preventive Health Care guideline update |
title | Screening for prostate cancer: protocol for updating multiple systematic reviews to inform a Canadian Task Force on Preventive Health Care guideline update |
title_full | Screening for prostate cancer: protocol for updating multiple systematic reviews to inform a Canadian Task Force on Preventive Health Care guideline update |
title_fullStr | Screening for prostate cancer: protocol for updating multiple systematic reviews to inform a Canadian Task Force on Preventive Health Care guideline update |
title_full_unstemmed | Screening for prostate cancer: protocol for updating multiple systematic reviews to inform a Canadian Task Force on Preventive Health Care guideline update |
title_short | Screening for prostate cancer: protocol for updating multiple systematic reviews to inform a Canadian Task Force on Preventive Health Care guideline update |
title_sort | screening for prostate cancer: protocol for updating multiple systematic reviews to inform a canadian task force on preventive health care guideline update |
topic | Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609189/ https://www.ncbi.nlm.nih.gov/pubmed/36289518 http://dx.doi.org/10.1186/s13643-022-02099-9 |
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