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Association of H3K9me3 with breast cancer prognosis by estrogen receptor status

BACKGROUND: Cellular experiments revealed that a decreased histone H3 lysine 9 trimethylation (H3K9me3) level was associated with the upregulation of oncogenes in breast cancer cells. Moreover, the role of H3K9me3 in breast cancer was closely associated with estrogen receptor (ER) status. Therefore,...

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Autores principales: Zhou, Meng, Yan, Jin-qi, Chen, Qian-xin, Yang, Yuan-zhong, Li, Yue-lin, Ren, Yue-xiang, Weng, Zi-jin, Zhang, Xiao-fang, Guan, Jie-xia, Tang, Lu-ying, Ren, Ze-fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609245/
https://www.ncbi.nlm.nih.gov/pubmed/36303253
http://dx.doi.org/10.1186/s13148-022-01363-y
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author Zhou, Meng
Yan, Jin-qi
Chen, Qian-xin
Yang, Yuan-zhong
Li, Yue-lin
Ren, Yue-xiang
Weng, Zi-jin
Zhang, Xiao-fang
Guan, Jie-xia
Tang, Lu-ying
Ren, Ze-fang
author_facet Zhou, Meng
Yan, Jin-qi
Chen, Qian-xin
Yang, Yuan-zhong
Li, Yue-lin
Ren, Yue-xiang
Weng, Zi-jin
Zhang, Xiao-fang
Guan, Jie-xia
Tang, Lu-ying
Ren, Ze-fang
author_sort Zhou, Meng
collection PubMed
description BACKGROUND: Cellular experiments revealed that a decreased histone H3 lysine 9 trimethylation (H3K9me3) level was associated with the upregulation of oncogenes in breast cancer cells. Moreover, the role of H3K9me3 in breast cancer was closely associated with estrogen receptor (ER) status. Therefore, we aimed to examine the prognostic value of H3K9me3 on breast cancer by ER status. The level of H3K9me3 in tumors were evaluated with tissue microarrays by immunohistochemistry for 917 women diagnosed with primary invasive breast cancer. Hazard ratios (HRs) and their 95% confidence intervals (CIs) for overall survival (OS) and progression-free survival (PFS) were estimated using Cox regression models. Interaction between H3K9me3 and ER on the prognosis was assessed on multiplicative scale. RESULTS: The level of H3K9me3 in tumor tissues was lower than that in adjacent tissues. The high level of H3K9me3 was associated with a better OS (HR = 0.43, 95% CI: 0.21–0.86) and PFS (HR = 0.49, 95% CI: 0.29–0.81) among only ER-positive but not ER-negative tumors. Moreover, the interaction between the level of H3K9me3 and ER status (negative and positive) on the prognosis was significant (P(interaction) = 0.011 for OS; P(interaction) = 0.022 for PFS). Furthermore, the ER-positive tumors were stratified by ER-low and ER-high positive tumors, and the prognostic role of H3K9me3 was significant among only ER-high positive patients (HR = 0.34, 95% CI: 0.13–0.85 for OS; HR = 0.47, 95% CI: 0.26–0.86 for PFS). CONCLUSIONS: Our study showed that the prognostic value of H3K9me3 on breast cancer was related to ER status and expression level, and the high level of H3K9me3 was associated with a better prognosis among ER-positive tumors, particularly ER-high positive tumors. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13148-022-01363-y.
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spelling pubmed-96092452022-10-28 Association of H3K9me3 with breast cancer prognosis by estrogen receptor status Zhou, Meng Yan, Jin-qi Chen, Qian-xin Yang, Yuan-zhong Li, Yue-lin Ren, Yue-xiang Weng, Zi-jin Zhang, Xiao-fang Guan, Jie-xia Tang, Lu-ying Ren, Ze-fang Clin Epigenetics Research BACKGROUND: Cellular experiments revealed that a decreased histone H3 lysine 9 trimethylation (H3K9me3) level was associated with the upregulation of oncogenes in breast cancer cells. Moreover, the role of H3K9me3 in breast cancer was closely associated with estrogen receptor (ER) status. Therefore, we aimed to examine the prognostic value of H3K9me3 on breast cancer by ER status. The level of H3K9me3 in tumors were evaluated with tissue microarrays by immunohistochemistry for 917 women diagnosed with primary invasive breast cancer. Hazard ratios (HRs) and their 95% confidence intervals (CIs) for overall survival (OS) and progression-free survival (PFS) were estimated using Cox regression models. Interaction between H3K9me3 and ER on the prognosis was assessed on multiplicative scale. RESULTS: The level of H3K9me3 in tumor tissues was lower than that in adjacent tissues. The high level of H3K9me3 was associated with a better OS (HR = 0.43, 95% CI: 0.21–0.86) and PFS (HR = 0.49, 95% CI: 0.29–0.81) among only ER-positive but not ER-negative tumors. Moreover, the interaction between the level of H3K9me3 and ER status (negative and positive) on the prognosis was significant (P(interaction) = 0.011 for OS; P(interaction) = 0.022 for PFS). Furthermore, the ER-positive tumors were stratified by ER-low and ER-high positive tumors, and the prognostic role of H3K9me3 was significant among only ER-high positive patients (HR = 0.34, 95% CI: 0.13–0.85 for OS; HR = 0.47, 95% CI: 0.26–0.86 for PFS). CONCLUSIONS: Our study showed that the prognostic value of H3K9me3 on breast cancer was related to ER status and expression level, and the high level of H3K9me3 was associated with a better prognosis among ER-positive tumors, particularly ER-high positive tumors. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13148-022-01363-y. BioMed Central 2022-10-27 /pmc/articles/PMC9609245/ /pubmed/36303253 http://dx.doi.org/10.1186/s13148-022-01363-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Zhou, Meng
Yan, Jin-qi
Chen, Qian-xin
Yang, Yuan-zhong
Li, Yue-lin
Ren, Yue-xiang
Weng, Zi-jin
Zhang, Xiao-fang
Guan, Jie-xia
Tang, Lu-ying
Ren, Ze-fang
Association of H3K9me3 with breast cancer prognosis by estrogen receptor status
title Association of H3K9me3 with breast cancer prognosis by estrogen receptor status
title_full Association of H3K9me3 with breast cancer prognosis by estrogen receptor status
title_fullStr Association of H3K9me3 with breast cancer prognosis by estrogen receptor status
title_full_unstemmed Association of H3K9me3 with breast cancer prognosis by estrogen receptor status
title_short Association of H3K9me3 with breast cancer prognosis by estrogen receptor status
title_sort association of h3k9me3 with breast cancer prognosis by estrogen receptor status
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609245/
https://www.ncbi.nlm.nih.gov/pubmed/36303253
http://dx.doi.org/10.1186/s13148-022-01363-y
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