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Similarities and differences between SUNCT and SUNA: a cross-sectional, multicentre study of 76 patients in China

BACKGROUND: Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA) have not been evaluated sufficiently due to limited data, particularly in China. METHOD...

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Autores principales: Zhang, Shuhua, Cao, Ya, Yan, Fanhong, Chen, Sufen, Gui, Wei, Hu, Dongmei, Liu, Huanxian, Li, Hongjin, Yu, Rongce, Wei, Dan, Wang, Xiaolin, Wang, Rongfei, Chen, Xiaoyan, Zhang, Mingjie, Ran, Ye, Jia, Zhihua, Han, Xun, He, Mianwang, Liu, Jing, Yu, Shengyuan, Dong, Zhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609258/
https://www.ncbi.nlm.nih.gov/pubmed/36289482
http://dx.doi.org/10.1186/s10194-022-01509-6
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author Zhang, Shuhua
Cao, Ya
Yan, Fanhong
Chen, Sufen
Gui, Wei
Hu, Dongmei
Liu, Huanxian
Li, Hongjin
Yu, Rongce
Wei, Dan
Wang, Xiaolin
Wang, Rongfei
Chen, Xiaoyan
Zhang, Mingjie
Ran, Ye
Jia, Zhihua
Han, Xun
He, Mianwang
Liu, Jing
Yu, Shengyuan
Dong, Zhao
author_facet Zhang, Shuhua
Cao, Ya
Yan, Fanhong
Chen, Sufen
Gui, Wei
Hu, Dongmei
Liu, Huanxian
Li, Hongjin
Yu, Rongce
Wei, Dan
Wang, Xiaolin
Wang, Rongfei
Chen, Xiaoyan
Zhang, Mingjie
Ran, Ye
Jia, Zhihua
Han, Xun
He, Mianwang
Liu, Jing
Yu, Shengyuan
Dong, Zhao
author_sort Zhang, Shuhua
collection PubMed
description BACKGROUND: Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA) have not been evaluated sufficiently due to limited data, particularly in China. METHODS: Patients with SUNCT or SUNA treated in a tertiary headache centre or seven other headache clinics of China between April 2009 and July 2022 were studied; we compared their demographics and clinical phenotypes. RESULTS: The 45 patients with SUNCT and 31 patients with SUNA had mean ages at onset of 37.22 ± 14.54 years and 42.45 ± 14.72 years, respectively. The mean ages at diagnosis of SUNCT and SUNA were 41.62 ± 12.70 years and 48.68 ± 13.80 years, respectively (p = 0.024). The correct diagnosis of SUNCT or SUNA was made after an average of 2.5 (0–20.5) years or 3.0 (0–20.7) years, respectively. Both diseases had a female predominance (SUNCT: 1.14:1; SUNA: 2.10:1). The two diseases differed in the most common attack site (temporal area in SUNCT, p = 0.017; parietal area in SUNA, p = 0.002). Qualitative descriptions of the attacks included stabbing pain (44.7%), electric-shock-like pain (36.8%), shooting pain (25.0%), and slashing pain (18.4%). Lacrimation was the most common autonomic symptom in both SUNCT and SUNA patients, while eyelid oedema, ptosis, and miosis were less frequent. Triggers such as cold air and face washing were shared by the two diseases, and they were consistently ipsilateral to the attack site. CONCLUSIONS: In contrast to Western countries, SUNCT and SUNA in China have a greater female predominance and an earlier onset. The shared core phenotype of SUNCT and SUNA, despite their partial differences, suggests that they are the same clinical entity.
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spelling pubmed-96092582022-10-28 Similarities and differences between SUNCT and SUNA: a cross-sectional, multicentre study of 76 patients in China Zhang, Shuhua Cao, Ya Yan, Fanhong Chen, Sufen Gui, Wei Hu, Dongmei Liu, Huanxian Li, Hongjin Yu, Rongce Wei, Dan Wang, Xiaolin Wang, Rongfei Chen, Xiaoyan Zhang, Mingjie Ran, Ye Jia, Zhihua Han, Xun He, Mianwang Liu, Jing Yu, Shengyuan Dong, Zhao J Headache Pain Research BACKGROUND: Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA) have not been evaluated sufficiently due to limited data, particularly in China. METHODS: Patients with SUNCT or SUNA treated in a tertiary headache centre or seven other headache clinics of China between April 2009 and July 2022 were studied; we compared their demographics and clinical phenotypes. RESULTS: The 45 patients with SUNCT and 31 patients with SUNA had mean ages at onset of 37.22 ± 14.54 years and 42.45 ± 14.72 years, respectively. The mean ages at diagnosis of SUNCT and SUNA were 41.62 ± 12.70 years and 48.68 ± 13.80 years, respectively (p = 0.024). The correct diagnosis of SUNCT or SUNA was made after an average of 2.5 (0–20.5) years or 3.0 (0–20.7) years, respectively. Both diseases had a female predominance (SUNCT: 1.14:1; SUNA: 2.10:1). The two diseases differed in the most common attack site (temporal area in SUNCT, p = 0.017; parietal area in SUNA, p = 0.002). Qualitative descriptions of the attacks included stabbing pain (44.7%), electric-shock-like pain (36.8%), shooting pain (25.0%), and slashing pain (18.4%). Lacrimation was the most common autonomic symptom in both SUNCT and SUNA patients, while eyelid oedema, ptosis, and miosis were less frequent. Triggers such as cold air and face washing were shared by the two diseases, and they were consistently ipsilateral to the attack site. CONCLUSIONS: In contrast to Western countries, SUNCT and SUNA in China have a greater female predominance and an earlier onset. The shared core phenotype of SUNCT and SUNA, despite their partial differences, suggests that they are the same clinical entity. Springer Milan 2022-10-26 /pmc/articles/PMC9609258/ /pubmed/36289482 http://dx.doi.org/10.1186/s10194-022-01509-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Zhang, Shuhua
Cao, Ya
Yan, Fanhong
Chen, Sufen
Gui, Wei
Hu, Dongmei
Liu, Huanxian
Li, Hongjin
Yu, Rongce
Wei, Dan
Wang, Xiaolin
Wang, Rongfei
Chen, Xiaoyan
Zhang, Mingjie
Ran, Ye
Jia, Zhihua
Han, Xun
He, Mianwang
Liu, Jing
Yu, Shengyuan
Dong, Zhao
Similarities and differences between SUNCT and SUNA: a cross-sectional, multicentre study of 76 patients in China
title Similarities and differences between SUNCT and SUNA: a cross-sectional, multicentre study of 76 patients in China
title_full Similarities and differences between SUNCT and SUNA: a cross-sectional, multicentre study of 76 patients in China
title_fullStr Similarities and differences between SUNCT and SUNA: a cross-sectional, multicentre study of 76 patients in China
title_full_unstemmed Similarities and differences between SUNCT and SUNA: a cross-sectional, multicentre study of 76 patients in China
title_short Similarities and differences between SUNCT and SUNA: a cross-sectional, multicentre study of 76 patients in China
title_sort similarities and differences between sunct and suna: a cross-sectional, multicentre study of 76 patients in china
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609258/
https://www.ncbi.nlm.nih.gov/pubmed/36289482
http://dx.doi.org/10.1186/s10194-022-01509-6
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