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Serum Procalcitonin Levels in Newly Diagnosed Hodgkin Lymphoma: Correlation with Other Inflammatory Biomarkers

Background and Objectives: Procalcitonin (PCT) is a useful biomarker for the diagnosis of sepsis. Inflammatory markers are elevated in patients with Hodgkin lymphoma (HL), and yet ongoing infection rarely coexists at diagnosis. PCT levels might be helpful in differentiating bacterial from disease-re...

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Autores principales: Piperidou, Alexia, Zografos, Eleftherios, Vassilakopoulos, Theodoros J., Angelopoulou, Maria K., Hillas, Georgios, Pappis, Vassiliki, Boutsikas, George, Dimou, Maria, Petevi, Kyriaki, Kanellopoulos, Alexandros, Kyrtsonis, Marie-Christine, Panayiotidis, Panayiotis, Vassilakopoulos, Theodoros P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609271/
https://www.ncbi.nlm.nih.gov/pubmed/36295492
http://dx.doi.org/10.3390/medicina58101331
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author Piperidou, Alexia
Zografos, Eleftherios
Vassilakopoulos, Theodoros J.
Angelopoulou, Maria K.
Hillas, Georgios
Pappis, Vassiliki
Boutsikas, George
Dimou, Maria
Petevi, Kyriaki
Kanellopoulos, Alexandros
Kyrtsonis, Marie-Christine
Panayiotidis, Panayiotis
Vassilakopoulos, Theodoros P.
author_facet Piperidou, Alexia
Zografos, Eleftherios
Vassilakopoulos, Theodoros J.
Angelopoulou, Maria K.
Hillas, Georgios
Pappis, Vassiliki
Boutsikas, George
Dimou, Maria
Petevi, Kyriaki
Kanellopoulos, Alexandros
Kyrtsonis, Marie-Christine
Panayiotidis, Panayiotis
Vassilakopoulos, Theodoros P.
author_sort Piperidou, Alexia
collection PubMed
description Background and Objectives: Procalcitonin (PCT) is a useful biomarker for the diagnosis of sepsis. Inflammatory markers are elevated in patients with Hodgkin lymphoma (HL), and yet ongoing infection rarely coexists at diagnosis. PCT levels might be helpful in differentiating bacterial from disease-related inflammation. Materials and Methods: We evaluated serum PCT levels and other inflammation markers in newly diagnosed HL patients. Values < 0.50 ng/mL were considered normal (0.10–0.50 ng/mL: detectable, <0.10 ng/mL: undetectable), while values ≥ 0.50 ng/L were considered elevated. Results: Among 137 patients, 55 had B symptoms (40%), 77/130 (59%) had elevated Erythrocyte Sedimentation Rate (ESR) and 116 (85%) had elevated C-Reactive Protein (CRP) (median 38.1 mg/L (range; 2.97–328)). PCT levels were normal in most patients (undetectable 94/137 (68.5%) and detectable 41/137(30%)) with median value < 0.10 ng/mL (range; <0.10–15.90). Elevated PCT was recorded in only two patients (1.5%). Patients with PCT < 0.10 ng/mL had significantly lower median CRP (25.75; range (2.97–203.0)) compared to patients with PCT ≥ 0.1 ng/mL (median CRP 92.50 mg/L; range (3.34–328.0)). Almost all patients (40/41, 97.6%) with detectable PCT had elevated CRP. Conclusions: This is the first study showing that the inflammation characterizing HL is not associated with PCT elevations, although CRP levels are elevated in 85% of the patients. Normal PCT levels may rule out the possibility of occult infection, thus preventing extensive evaluation, which may delay treatment initiation.
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spelling pubmed-96092712022-10-28 Serum Procalcitonin Levels in Newly Diagnosed Hodgkin Lymphoma: Correlation with Other Inflammatory Biomarkers Piperidou, Alexia Zografos, Eleftherios Vassilakopoulos, Theodoros J. Angelopoulou, Maria K. Hillas, Georgios Pappis, Vassiliki Boutsikas, George Dimou, Maria Petevi, Kyriaki Kanellopoulos, Alexandros Kyrtsonis, Marie-Christine Panayiotidis, Panayiotis Vassilakopoulos, Theodoros P. Medicina (Kaunas) Article Background and Objectives: Procalcitonin (PCT) is a useful biomarker for the diagnosis of sepsis. Inflammatory markers are elevated in patients with Hodgkin lymphoma (HL), and yet ongoing infection rarely coexists at diagnosis. PCT levels might be helpful in differentiating bacterial from disease-related inflammation. Materials and Methods: We evaluated serum PCT levels and other inflammation markers in newly diagnosed HL patients. Values < 0.50 ng/mL were considered normal (0.10–0.50 ng/mL: detectable, <0.10 ng/mL: undetectable), while values ≥ 0.50 ng/L were considered elevated. Results: Among 137 patients, 55 had B symptoms (40%), 77/130 (59%) had elevated Erythrocyte Sedimentation Rate (ESR) and 116 (85%) had elevated C-Reactive Protein (CRP) (median 38.1 mg/L (range; 2.97–328)). PCT levels were normal in most patients (undetectable 94/137 (68.5%) and detectable 41/137(30%)) with median value < 0.10 ng/mL (range; <0.10–15.90). Elevated PCT was recorded in only two patients (1.5%). Patients with PCT < 0.10 ng/mL had significantly lower median CRP (25.75; range (2.97–203.0)) compared to patients with PCT ≥ 0.1 ng/mL (median CRP 92.50 mg/L; range (3.34–328.0)). Almost all patients (40/41, 97.6%) with detectable PCT had elevated CRP. Conclusions: This is the first study showing that the inflammation characterizing HL is not associated with PCT elevations, although CRP levels are elevated in 85% of the patients. Normal PCT levels may rule out the possibility of occult infection, thus preventing extensive evaluation, which may delay treatment initiation. MDPI 2022-09-22 /pmc/articles/PMC9609271/ /pubmed/36295492 http://dx.doi.org/10.3390/medicina58101331 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Piperidou, Alexia
Zografos, Eleftherios
Vassilakopoulos, Theodoros J.
Angelopoulou, Maria K.
Hillas, Georgios
Pappis, Vassiliki
Boutsikas, George
Dimou, Maria
Petevi, Kyriaki
Kanellopoulos, Alexandros
Kyrtsonis, Marie-Christine
Panayiotidis, Panayiotis
Vassilakopoulos, Theodoros P.
Serum Procalcitonin Levels in Newly Diagnosed Hodgkin Lymphoma: Correlation with Other Inflammatory Biomarkers
title Serum Procalcitonin Levels in Newly Diagnosed Hodgkin Lymphoma: Correlation with Other Inflammatory Biomarkers
title_full Serum Procalcitonin Levels in Newly Diagnosed Hodgkin Lymphoma: Correlation with Other Inflammatory Biomarkers
title_fullStr Serum Procalcitonin Levels in Newly Diagnosed Hodgkin Lymphoma: Correlation with Other Inflammatory Biomarkers
title_full_unstemmed Serum Procalcitonin Levels in Newly Diagnosed Hodgkin Lymphoma: Correlation with Other Inflammatory Biomarkers
title_short Serum Procalcitonin Levels in Newly Diagnosed Hodgkin Lymphoma: Correlation with Other Inflammatory Biomarkers
title_sort serum procalcitonin levels in newly diagnosed hodgkin lymphoma: correlation with other inflammatory biomarkers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609271/
https://www.ncbi.nlm.nih.gov/pubmed/36295492
http://dx.doi.org/10.3390/medicina58101331
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