Cargando…

Monitoring the Subolesin Vaccine Field Trial for Safer Control of Cattle Ticks Amidst Increasing Acaricide Resistance in Uganda

A collaboration program was established between the group of Health and Biotechnology (SaBio) of the IREC Institute of Game and Wildlife Research (CSIC-UCLM-JCCM, Spain) and the National Agricultural Research Organization of Uganda (NARO) for the development of vaccines for the control of cattle tic...

Descripción completa

Detalles Bibliográficos
Autores principales: Kabi, Fredrick, Dhikusooka, Moses, Matovu, Moses, Mugerwa, Swidiq, Kasaija, Paul, Emudong, Patrick, Kirunda, Halid, Contreras, Marinela, Gortazar, Christian, De la Fuente, Jose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609280/
https://www.ncbi.nlm.nih.gov/pubmed/36298461
http://dx.doi.org/10.3390/vaccines10101594
_version_ 1784818978807349248
author Kabi, Fredrick
Dhikusooka, Moses
Matovu, Moses
Mugerwa, Swidiq
Kasaija, Paul
Emudong, Patrick
Kirunda, Halid
Contreras, Marinela
Gortazar, Christian
De la Fuente, Jose
author_facet Kabi, Fredrick
Dhikusooka, Moses
Matovu, Moses
Mugerwa, Swidiq
Kasaija, Paul
Emudong, Patrick
Kirunda, Halid
Contreras, Marinela
Gortazar, Christian
De la Fuente, Jose
author_sort Kabi, Fredrick
collection PubMed
description A collaboration program was established between the group of Health and Biotechnology (SaBio) of the IREC Institute of Game and Wildlife Research (CSIC-UCLM-JCCM, Spain) and the National Agricultural Research Organization of Uganda (NARO) for the development of vaccines for the control of cattle ticks in Uganda. Controlled pen trials identified a tick protective antigen, Rhipicephalus appendiculatus Subolesin, and a cross-species-effective vaccine formulation. As the next step, a controlled vaccine field trial has been approved by Ugandan state regulatory authorities, the Uganda National Council for Science and Technology (UNCST) and the National Drug Authority (NDA), to evaluate the efficacy and effectiveness of the vaccine formulation for the control of cattle tick infestations under field conditions. The results of this trial may lead to the approval of the vaccine for application in Uganda to improve cattle health and production while reducing the use of acaricides.
format Online
Article
Text
id pubmed-9609280
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96092802022-10-28 Monitoring the Subolesin Vaccine Field Trial for Safer Control of Cattle Ticks Amidst Increasing Acaricide Resistance in Uganda Kabi, Fredrick Dhikusooka, Moses Matovu, Moses Mugerwa, Swidiq Kasaija, Paul Emudong, Patrick Kirunda, Halid Contreras, Marinela Gortazar, Christian De la Fuente, Jose Vaccines (Basel) Commentary A collaboration program was established between the group of Health and Biotechnology (SaBio) of the IREC Institute of Game and Wildlife Research (CSIC-UCLM-JCCM, Spain) and the National Agricultural Research Organization of Uganda (NARO) for the development of vaccines for the control of cattle ticks in Uganda. Controlled pen trials identified a tick protective antigen, Rhipicephalus appendiculatus Subolesin, and a cross-species-effective vaccine formulation. As the next step, a controlled vaccine field trial has been approved by Ugandan state regulatory authorities, the Uganda National Council for Science and Technology (UNCST) and the National Drug Authority (NDA), to evaluate the efficacy and effectiveness of the vaccine formulation for the control of cattle tick infestations under field conditions. The results of this trial may lead to the approval of the vaccine for application in Uganda to improve cattle health and production while reducing the use of acaricides. MDPI 2022-09-22 /pmc/articles/PMC9609280/ /pubmed/36298461 http://dx.doi.org/10.3390/vaccines10101594 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Commentary
Kabi, Fredrick
Dhikusooka, Moses
Matovu, Moses
Mugerwa, Swidiq
Kasaija, Paul
Emudong, Patrick
Kirunda, Halid
Contreras, Marinela
Gortazar, Christian
De la Fuente, Jose
Monitoring the Subolesin Vaccine Field Trial for Safer Control of Cattle Ticks Amidst Increasing Acaricide Resistance in Uganda
title Monitoring the Subolesin Vaccine Field Trial for Safer Control of Cattle Ticks Amidst Increasing Acaricide Resistance in Uganda
title_full Monitoring the Subolesin Vaccine Field Trial for Safer Control of Cattle Ticks Amidst Increasing Acaricide Resistance in Uganda
title_fullStr Monitoring the Subolesin Vaccine Field Trial for Safer Control of Cattle Ticks Amidst Increasing Acaricide Resistance in Uganda
title_full_unstemmed Monitoring the Subolesin Vaccine Field Trial for Safer Control of Cattle Ticks Amidst Increasing Acaricide Resistance in Uganda
title_short Monitoring the Subolesin Vaccine Field Trial for Safer Control of Cattle Ticks Amidst Increasing Acaricide Resistance in Uganda
title_sort monitoring the subolesin vaccine field trial for safer control of cattle ticks amidst increasing acaricide resistance in uganda
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609280/
https://www.ncbi.nlm.nih.gov/pubmed/36298461
http://dx.doi.org/10.3390/vaccines10101594
work_keys_str_mv AT kabifredrick monitoringthesubolesinvaccinefieldtrialforsafercontrolofcattleticksamidstincreasingacaricideresistanceinuganda
AT dhikusookamoses monitoringthesubolesinvaccinefieldtrialforsafercontrolofcattleticksamidstincreasingacaricideresistanceinuganda
AT matovumoses monitoringthesubolesinvaccinefieldtrialforsafercontrolofcattleticksamidstincreasingacaricideresistanceinuganda
AT mugerwaswidiq monitoringthesubolesinvaccinefieldtrialforsafercontrolofcattleticksamidstincreasingacaricideresistanceinuganda
AT kasaijapaul monitoringthesubolesinvaccinefieldtrialforsafercontrolofcattleticksamidstincreasingacaricideresistanceinuganda
AT emudongpatrick monitoringthesubolesinvaccinefieldtrialforsafercontrolofcattleticksamidstincreasingacaricideresistanceinuganda
AT kirundahalid monitoringthesubolesinvaccinefieldtrialforsafercontrolofcattleticksamidstincreasingacaricideresistanceinuganda
AT contrerasmarinela monitoringthesubolesinvaccinefieldtrialforsafercontrolofcattleticksamidstincreasingacaricideresistanceinuganda
AT gortazarchristian monitoringthesubolesinvaccinefieldtrialforsafercontrolofcattleticksamidstincreasingacaricideresistanceinuganda
AT delafuentejose monitoringthesubolesinvaccinefieldtrialforsafercontrolofcattleticksamidstincreasingacaricideresistanceinuganda