The Roles of microRNA miR-185 in Digestive Tract Cancers

Digestive tract cancers represent a serious public health issue. In recent years, evidence has accumulated that microRNA miR-185 is implicated in the pathogenesis of this group of highly malignant tumors. Its expression variations correlate with clinical features, such as tumor size, lymph node meta...

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Autores principales: Babaeenezhad, Esmaeel, Naghibalhossaini, Fakhraddin, Rajabibazl, Masoumeh, Jangravi, Zohreh, Hadipour Moradi, Forouzan, Fattahi, Mohammad Davood, Hoheisel, Jörg D., Sarabi, Mostafa Moradi, Shahryarhesami, Soroosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609348/
https://www.ncbi.nlm.nih.gov/pubmed/36287119
http://dx.doi.org/10.3390/ncrna8050067
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author Babaeenezhad, Esmaeel
Naghibalhossaini, Fakhraddin
Rajabibazl, Masoumeh
Jangravi, Zohreh
Hadipour Moradi, Forouzan
Fattahi, Mohammad Davood
Hoheisel, Jörg D.
Sarabi, Mostafa Moradi
Shahryarhesami, Soroosh
author_facet Babaeenezhad, Esmaeel
Naghibalhossaini, Fakhraddin
Rajabibazl, Masoumeh
Jangravi, Zohreh
Hadipour Moradi, Forouzan
Fattahi, Mohammad Davood
Hoheisel, Jörg D.
Sarabi, Mostafa Moradi
Shahryarhesami, Soroosh
author_sort Babaeenezhad, Esmaeel
collection PubMed
description Digestive tract cancers represent a serious public health issue. In recent years, evidence has accumulated that microRNA miR-185 is implicated in the pathogenesis of this group of highly malignant tumors. Its expression variations correlate with clinical features, such as tumor size, lymph node metastasis, tumor node metastatic stage, survival, recurrence and response to adjuvant therapy, and have diagnostic and prognostic potential. In this review, we compile, evaluate and discuss the current knowledge about the roles of miR-185 in digestive tract cancers. Interestingly, miR-185 is apparently involved in regulating both tumor suppressive and oncogenic processes. We look at downstream effects as well as upstream regulation. In addition, we discuss the utility of miR-185 for diagnosis and its potential concerning novel therapeutic approaches.
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spelling pubmed-96093482022-10-28 The Roles of microRNA miR-185 in Digestive Tract Cancers Babaeenezhad, Esmaeel Naghibalhossaini, Fakhraddin Rajabibazl, Masoumeh Jangravi, Zohreh Hadipour Moradi, Forouzan Fattahi, Mohammad Davood Hoheisel, Jörg D. Sarabi, Mostafa Moradi Shahryarhesami, Soroosh Noncoding RNA Review Digestive tract cancers represent a serious public health issue. In recent years, evidence has accumulated that microRNA miR-185 is implicated in the pathogenesis of this group of highly malignant tumors. Its expression variations correlate with clinical features, such as tumor size, lymph node metastasis, tumor node metastatic stage, survival, recurrence and response to adjuvant therapy, and have diagnostic and prognostic potential. In this review, we compile, evaluate and discuss the current knowledge about the roles of miR-185 in digestive tract cancers. Interestingly, miR-185 is apparently involved in regulating both tumor suppressive and oncogenic processes. We look at downstream effects as well as upstream regulation. In addition, we discuss the utility of miR-185 for diagnosis and its potential concerning novel therapeutic approaches. MDPI 2022-10-08 /pmc/articles/PMC9609348/ /pubmed/36287119 http://dx.doi.org/10.3390/ncrna8050067 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Babaeenezhad, Esmaeel
Naghibalhossaini, Fakhraddin
Rajabibazl, Masoumeh
Jangravi, Zohreh
Hadipour Moradi, Forouzan
Fattahi, Mohammad Davood
Hoheisel, Jörg D.
Sarabi, Mostafa Moradi
Shahryarhesami, Soroosh
The Roles of microRNA miR-185 in Digestive Tract Cancers
title The Roles of microRNA miR-185 in Digestive Tract Cancers
title_full The Roles of microRNA miR-185 in Digestive Tract Cancers
title_fullStr The Roles of microRNA miR-185 in Digestive Tract Cancers
title_full_unstemmed The Roles of microRNA miR-185 in Digestive Tract Cancers
title_short The Roles of microRNA miR-185 in Digestive Tract Cancers
title_sort roles of microrna mir-185 in digestive tract cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609348/
https://www.ncbi.nlm.nih.gov/pubmed/36287119
http://dx.doi.org/10.3390/ncrna8050067
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