Atom Economical Multi-Substituted Pyrrole Synthesis from Aziridine

Multi-substituted pyrroles are synthesized from regiospecific aziridine ring-opening and subsequent intramolecular cyclization with a carbonyl group at the γ-position in the presence of Lewis acid or protic acid. This method is highly atom economical where all the atoms of the reactants are incorpor...

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Detalles Bibliográficos
Autores principales: Macha, Lingamurthy, Jala, Ranjith, Na, Sang-Yun, Ha, Hyun-Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609358/
https://www.ncbi.nlm.nih.gov/pubmed/36296466
http://dx.doi.org/10.3390/molecules27206869
Descripción
Sumario:Multi-substituted pyrroles are synthesized from regiospecific aziridine ring-opening and subsequent intramolecular cyclization with a carbonyl group at the γ-position in the presence of Lewis acid or protic acid. This method is highly atom economical where all the atoms of the reactants are incorporated into the final product with the removal of water. This new protocol is applied to the synthesis of various pyrroles, including natural products.

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