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Aseptic Abscess Syndrome in Rheumatoid Arthritis Patient
Aseptic abscess syndrome (AAS) is a rare, potentially life-threatening disorder, with numerous features of neutrophilic dermatoses. The main symptoms include aseptic abscess-like collections in internal organs (spleen, liver, lungs), lack of microbes (bacteria, viruses, or parasites) after an exhaus...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609381/ https://www.ncbi.nlm.nih.gov/pubmed/36295515 http://dx.doi.org/10.3390/medicina58101354 |
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author | Owczarczyk-Saczonek, Agnieszka Kasprowicz-Furmańczyk, Marta Kuna, Jakub Klimek, Paulina Krajewska-Włodarczyk, Magdalena |
author_facet | Owczarczyk-Saczonek, Agnieszka Kasprowicz-Furmańczyk, Marta Kuna, Jakub Klimek, Paulina Krajewska-Włodarczyk, Magdalena |
author_sort | Owczarczyk-Saczonek, Agnieszka |
collection | PubMed |
description | Aseptic abscess syndrome (AAS) is a rare, potentially life-threatening disorder, with numerous features of neutrophilic dermatoses. The main symptoms include aseptic abscess-like collections in internal organs (spleen, liver, lungs), lack of microbes (bacteria, viruses, or parasites) after an exhaustive search, ineffectiveness of antibiotics, and high sensitivity to corticosteroid therapy. AAS is characterized by the development of deep, inflammatory abscesses and systemic symptoms (weight loss, abdominal pain, fever, and leukocytosis). They may be associated with inflammatory bowel disease (IBD) and autoimmune diseases. The patient in this study is a 67-year-old man, suffering from rheumatoid arthritis (RA), with numerous purulent abscesses in the mediastinum, within the subcutaneous tissue above the extension surfaces of the joints, and on the dorsum of the hands. The lesions are accompanied by bone destruction. The patient was treated with prednisone 40 mg and adalimumab, which resulted in a quick reduction of inflammatory markers and clinical improvement, as well as the healing and absorption of abscesses. Despite COVID-19 infection, treatment with remdesivir, prednisone, and adalimumab was continued, with the complete resolution of the lesions. AAS is difficult to recognize, so practitioners have to be aware of this condition, especially in patients with RA. |
format | Online Article Text |
id | pubmed-9609381 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96093812022-10-28 Aseptic Abscess Syndrome in Rheumatoid Arthritis Patient Owczarczyk-Saczonek, Agnieszka Kasprowicz-Furmańczyk, Marta Kuna, Jakub Klimek, Paulina Krajewska-Włodarczyk, Magdalena Medicina (Kaunas) Case Report Aseptic abscess syndrome (AAS) is a rare, potentially life-threatening disorder, with numerous features of neutrophilic dermatoses. The main symptoms include aseptic abscess-like collections in internal organs (spleen, liver, lungs), lack of microbes (bacteria, viruses, or parasites) after an exhaustive search, ineffectiveness of antibiotics, and high sensitivity to corticosteroid therapy. AAS is characterized by the development of deep, inflammatory abscesses and systemic symptoms (weight loss, abdominal pain, fever, and leukocytosis). They may be associated with inflammatory bowel disease (IBD) and autoimmune diseases. The patient in this study is a 67-year-old man, suffering from rheumatoid arthritis (RA), with numerous purulent abscesses in the mediastinum, within the subcutaneous tissue above the extension surfaces of the joints, and on the dorsum of the hands. The lesions are accompanied by bone destruction. The patient was treated with prednisone 40 mg and adalimumab, which resulted in a quick reduction of inflammatory markers and clinical improvement, as well as the healing and absorption of abscesses. Despite COVID-19 infection, treatment with remdesivir, prednisone, and adalimumab was continued, with the complete resolution of the lesions. AAS is difficult to recognize, so practitioners have to be aware of this condition, especially in patients with RA. MDPI 2022-09-27 /pmc/articles/PMC9609381/ /pubmed/36295515 http://dx.doi.org/10.3390/medicina58101354 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Owczarczyk-Saczonek, Agnieszka Kasprowicz-Furmańczyk, Marta Kuna, Jakub Klimek, Paulina Krajewska-Włodarczyk, Magdalena Aseptic Abscess Syndrome in Rheumatoid Arthritis Patient |
title | Aseptic Abscess Syndrome in Rheumatoid Arthritis Patient |
title_full | Aseptic Abscess Syndrome in Rheumatoid Arthritis Patient |
title_fullStr | Aseptic Abscess Syndrome in Rheumatoid Arthritis Patient |
title_full_unstemmed | Aseptic Abscess Syndrome in Rheumatoid Arthritis Patient |
title_short | Aseptic Abscess Syndrome in Rheumatoid Arthritis Patient |
title_sort | aseptic abscess syndrome in rheumatoid arthritis patient |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609381/ https://www.ncbi.nlm.nih.gov/pubmed/36295515 http://dx.doi.org/10.3390/medicina58101354 |
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