Cargando…

Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells

Circular RNAs (circRNAs) have recently been implicated in impaired β-cell function in diabetes. Using microarray-based profiling of circRNAs in human EndoC-βH1 cells treated with pro-inflammatory cytokines, this study aimed to investigate the expression and possible regulatory roles of circRNAs in h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kaur, Simranjeet, Frørup, Caroline, Mirza, Aashiq H., Fløyel, Tina, Yarani, Reza, Colli, Maikel L., Johannesen, Jesper, Størling, Joachim, Eizirik, Decio L., Pociot, Flemming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609391/ https://www.ncbi.nlm.nih.gov/pubmed/36287121 http://dx.doi.org/10.3390/ncrna8050069

Ejemplares similares

Cathepsin C Regulates Cytokine-Induced Apoptosis in β-Cell Model Systems
por: Fløyel, Tina, et al.
Publicado: (2021)

Characterization of the functional and transcriptomic effects of pro-inflammatory cytokines on human EndoC-βH5 beta cells
por: Frørup, Caroline, et al.
Publicado: (2023)

Plasma Exosome-Enriched Extracellular Vesicles From Lactating Mothers With Type 1 Diabetes Contain Aberrant Levels of miRNAs During the Postpartum Period
por: Frørup, Caroline, et al.
Publicado: (2021)

The emerging role of lncRNAs in inflammatory bowel disease
por: Yarani, Reza, et al.
Publicado: (2018)

Cell Type-Selective Expression of Circular RNAs in Human Pancreatic Islets
por: Kaur, Simranjeet, et al.
Publicado: (2018)

A Dual Systems Genetics Approach Identifies Common Genes, Networks, and Pathways for Type 1 and 2 Diabetes in Human Islets
por: Kaur, Simranjeet, et al.
Publicado: (2021)

SKAP2, a Candidate Gene for Type 1 Diabetes, Regulates β-Cell Apoptosis and Glycemic Control in Newly Diagnosed Patients
por: Fløyel, Tina, et al.
Publicado: (2021)

Breast Milk-Derived Extracellular Vesicles Enriched in Exosomes From Mothers With Type 1 Diabetes Contain Aberrant Levels of microRNAs
por: Mirza, Aashiq H., et al.
Publicado: (2019)

Long non-coding RNAs as novel players in β cell function and type 1 diabetes
por: Mirza, Aashiq H., et al.
Publicado: (2017)

β Cell and Autophagy: What Do We Know?
por: Mohammadi-Motlagh, Hamid-Reza, et al.
Publicado: (2023)

Effects of GWAS-Associated Genetic Variants on lncRNAs within IBD and T1D Candidate Loci
por: Mirza, Aashiq H., et al.
Publicado: (2014)

Systemic TNFα correlates with residual β-cell function in children and adolescents newly diagnosed with type 1 diabetes
por: Overgaard, Anne Julie, et al.
Publicado: (2020)

Circulating Inflammatory Markers Are Inversely Associated with Heart Rate Variability Measures in Type 1 Diabetes
por: Wegeberg, Anne-Marie L., et al.
Publicado: (2020)

Genetic Variants Associated with Neuropeptide Y Autoantibody Levels in Newly Diagnosed Individuals with Type 1 Diabetes
por: Mansachs, Sara Juul, et al.
Publicado: (2022)

Molecular Footprints of the Immune Assault on Pancreatic Beta Cells in Type 1 Diabetes
por: Colli, Maikel L., et al.
Publicado: (2020)

Type 1 Diabetes Candidate Genes Linked to Pancreatic Islet Cell Inflammation and Beta-Cell Apoptosis
por: Størling, Joachim, et al.
Publicado: (2017)

Influence of Disease Duration on Circulating Levels of miRNAs in Children and Adolescents with New Onset Type 1 Diabetes
por: Samandari, Nasim, et al.
Publicado: (2018)

Alu Elements as Novel Regulators of Gene Expression in Type 1 Diabetes Susceptibility Genes?
por: Kaur, Simranjeet, et al.
Publicado: (2015)

Genetic Risk Score Modelling for Disease Progression in New-Onset Type 1 Diabetes Patients: Increased Genetic Load of Islet-Expressed and Cytokine-Regulated Candidate Genes Predicts Poorer Glycemic Control
por: Brorsson, Caroline A., et al.
Publicado: (2016)

Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression
por: Bergholdt, Regine, et al.
Publicado: (2012)

MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA
por: Colli, Maikel L., et al.
Publicado: (2010)

MicroRNAs and histone deacetylase inhibition-mediated protection against inflammatory β-cell damage
por: Lindeløv Vestergaard, Anna, et al.
Publicado: (2018)

Low-grade inflammation in type 2 diabetes: a cross-sectional study from a Danish diabetes outpatient clinic
por: Okdahl, Tina, et al.
Publicado: (2022)

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines
por: Eizirik, Décio L., et al.
Publicado: (2012)

Cytokines Interleukin-1β and Tumor Necrosis Factor-α Regulate Different Transcriptional and Alternative Splicing Networks in Primary β-Cells
por: Ortis, Fernanda, et al.
Publicado: (2010)

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic β-Cell Apoptosis via Regulation of the BH3-Only Protein Bim
por: Santin, Izortze, et al.
Publicado: (2011)

Independent component and pathway-based analysis of miRNA-regulated gene expression in a model of type 1 diabetes
por: Bang-Berthelsen, Claus H, et al.
Publicado: (2011)

The impact of pro-inflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes
por: Ramos-Rodríguez, Mireia, et al.
Publicado: (2019)

Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells
por: Demine, Stéphane, et al.
Publicado: (2020)

Cross-species high-resolution transcriptome profiling suggests biomarkers and therapeutic targets for ulcerative colitis
por: Yarani, Reza, et al.
Publicado: (2023)

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-γ–Induced Pancreatic β-Cell Apoptosis
por: Moore, Fabrice, et al.
Publicado: (2009)

Transcriptomic landscape of lncRNAs in inflammatory bowel disease
por: Mirza, Aashiq H, et al.
Publicado: (2015)

Children at onset of type 1 diabetes show altered N-glycosylation of plasma proteins and IgG
por: Rudman, Najda, et al.
Publicado: (2022)

No Contribution of GAD-65 and IA-2 Autoantibodies around Time of Diagnosis to the Increasing Incidence of Juvenile Type 1 Diabetes: A 9-Year Nationwide Danish Study
por: Thorsen, Steffen U., et al.
Publicado: (2016)

Circulating MicroRNAs in Plasma of Hepatitis B e Antigen Positive Children Reveal Liver-Specific Target Genes
por: Winther, Thilde Nordmann, et al.
Publicado: (2014)

Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells
por: Vig, Saurabh, et al.
Publicado: (2019)

Differentially Expressed miRNAs in Ulcerative Colitis and Crohn’s Disease
por: Yarani, Reza, et al.
Publicado: (2022)

Exposure to the Viral By-Product dsRNA or Coxsackievirus B5 Triggers Pancreatic Beta Cell Apoptosis via a Bim / Mcl-1 Imbalance
por: Colli, Maikel L., et al.
Publicado: (2011)

ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation
por: Szymczak, Florian, et al.
Publicado: (2022)

Characterization of plasma lipidomics in adolescent subjects with increased risk for type 1 diabetes in the DiPiS cohort
por: Andersson Svärd, Agnes, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_qsujce9024gut3f123taqr85j7